Macrocytic Anemia Flashcards
1
Q
1 Lab and 1 Presentation Difference between Folate and B12 Deficiencies
A
Folate - normal methylmalonic acid, no neuro symptoms
B12: Increased methylmalonic acid, neuro symptoms
2
Q
Drug that Causes
A
Methotrexate - Folate deficiency bc inhibits DHF reductase
3
Q
Diphyloobothrium latum
A
Fish tapeworm that can cause B12 deficiency
4
Q
Orotic Aciduria
A
Defect of UMP synthase in pyrimidine synthesis, causing megaloblastic anemia not corrected by folate/B12
5
Q
Important note about treating folate deficiency
A
Also give B12, because that might also be a problem that you just hide by giving folate
6
Q
Nonmegaloblastic Macrocytic Anemias (what it is, 4 causes)
A
DNA Synthesis unimpaired so no hypersegmented neutrophils Alcoholism Liver disease Hypothyroidism Reticulocytosis
