Multiple Endocrine Neoplasia Flashcards
1
Q
How does MEN affect multiple sites?
A
Tumors arise from common amine precursor uptake and decarboxylation cells
2
Q
MEN 1
Tumor Sites and Associated Conditions
A
The 3 P’s:
Parathyroid: hyperPTH causing hypercalcemia
Pancreas: Zollinger Ellison syndrome causing ulcers
Pituitary: Hyperprolactinemia causing amenorrhea/impotence
3
Q
MEN 2A
Tumor Sites and Associated Conditions
A
Medullary Thyroid Carcinoma: C cell tumor
Pheochromocytoma
Hyperparathyroidism
Can see cutaneous lichen amyloidosis
4
Q
MEN 2B
Tumor Sites and Associated Conditions
A
Medullary Thyroid Carcinoma: C cell tumor
Pheochromocytoma
Mucosal Neuromas
Can see Marfanoid Body Habitus
5
Q
MEN Gene Defects
Type 1 and Type 2
A
Type 1: Men1 menin gene
Type 2: RET protooncogene for tyrosine kinase
