Hypothalamus-Pituitary Relationships Flashcards
Thyroid Stimulating Hormone Regulation
Positive feedback via TRH from Hypothalamus
Adrenocorticotropic Hormone Regulation
Positive feedback via CRH from Hypothalamus
Follicle Stimulating Hormone Regulation
Positive feedback via GnRH from Hypothalamus
Luteinizing Hormone Regulation
Positive feedback via GnRH from Hypothalamus
Growth Hormone Regulation
Positive feedback from GHRH via Hypothalamus
Positive feedback of GH and Somatomedins on Hypothalamus
Negative feedback from Somatostatin via Hypothalamus
Negative feedback from Somatostatin and Somatomedins from periphery on Anterior Pituitary
Negative feedback of GHRH on hypothalamus
Prolactin Regulation
Negative feedback via Dopamine (PIF) from Hypothalamus (primary regulation)
Positive feedback via TRH from hypothalamus
Growth Hormone Actions
Non-Fasting and Fasting
Increases blood glucose
Increases protein synthesis, organ and bone growth via somatomedins
Fasting: GH increases while Somatomedins and Insulin decrease
Antidiuretic Hormone
Release Triggers and Actions
Decreased BP (baroreceptors), decreased arterial stretch or increased osmolarity
Increases water reabsorption and causes vasoconstriction
Central Diabetes Insipidus
Caused by lack of ADH release from Supraoptic Nuclei
Responsive to desmopressin treatment
Nephrogenic Diabetes Insipidus
Caused by lack of response by kidneys to ADH
Unresponsive to desmopressin
SIADH
Excessive ADH secretion leading to water retention that is unresponsive to hypo-osmolarity
Prolactin Actions
Causes lactation and decreases gonadotropins (FSH/LH)
Excess can cause amenorrhea
Oxytocin Synthesis Site and Actions
Made in Paraventricular nuclei
Increases milk production and uterine contraction
