Endocrine Pancreas

Question 1

Beta Cell Secretions

Answer 1

Insulin and C Peptide

Question 2

Alpha Cell Secretion

Answer 2

Glucagon

Question 3

Delta Cell Secretion

Answer 3

Somatostatin

Question 4

Insulin Stimulation

Answer 4

Increased Glucose, FAs, AAs, Potassium, Cortisol

Glucagon/GLP-1/GIP (via Gs)

Ach/CCK (via Gq)

Question 5

Insulin Inhibition

Answer 5

Somatostatin (via Gi)

Adrenergic receptor activation

Fasting, Exercise or Decreased Glucose

Question 6

Insulin Actions

Answer 6

Increased Glucose/Potassium uptake, Glycogenesis, Protein Synthesis, Lipid Synthesis

Decreased Gluconeogenesis, Glycogenolysis, Lipolysis,

Question 7

Type 1 Diabetes Characteristics

Answer 7

Increased blood Glucose/FA/AA/Ketoacids
Metabolic Acidosis

Decreased Potassium uptake
Hyperkalemia

Osmotic Diuresis

Question 8

Type 2 Diabetes Characteristics

Answer 8

Decreased GLUT4 functioning
Decreased inhibition of hepatic glucose by insulin
Decreased inhibition of HSL by insulin
Decreased incretin effect

Hyperglucagonemia
Less prone to ketoacidosis

Question 9

Glucagon Stimulation

Answer 9

Decreased blood glucose (fasting)

Increased AA, CCK, Ach and Beta agonists

Question 10

Glucagon Inhibition

Answer 10

Increased Insulin, Somatostatin, FAs and Ketoacids

Question 11

Glucagon Liver Effects

Answer 11

Increased glycogenolysis, gluconeogenesis and lipolysis

Decreased glycogenesis and FA synthesis