Mucus and CF

Question 1

What does the sodium ion channel do?

Answer 1

Allows Na+ to flow through the membrane by facilitated diffusion

Question 2

What does the CFTR channel do?

Answer 2

Allows Cl- (chloride ions) to flow through.

Question 3

What does the sodium pump do?

Answer 3

Pumps Na+ out of the basal end of the membrane

Question 4

What effect does the CFTR channel have on the sodium ion channel?

Answer 4

When the CFTR channel is open, the sodium ion channel CANNOT open

Question 5

Describe a normal situation (mucus is normal)?

Answer 5

Sodium ion pump open
Sodium ion channel open
CFTR channel closed

Question 6

Describe a situation with dehydrated mucus

Answer 6

CFTR channel is open
Sodium ion channel closes
Sodium ion pump open

Question 7

Describe a CF situation

Answer 7

CFTR is absent or not functional
Sodium ion channel is always open
Sodium pump is open

Question 8

What three channels/pumps are in epithelial cells?

Answer 8

Sodium ion channel

CFTR channel

Sodium pump