MSK review Flashcards
pt w target rash, previous hunting trip
dx is ___
at risk for ____
bacterial cause is __
lyme dz
carditis
borrellia bungdorfi
35 yr old man, 3 day history of hemoptysis and rash
multiple episodes of sinusitis
skin rash over les
dx is ___
mechanism: ___ of vasc endothelium
vasculitis
inflammation
teenager, hx of facial rash
PE shows open/closed comedones
cause of skin findings: stimulation of __ by ___
sebaceous glands, androgens
young girl, 6w of itchy rash on elbows and backs of knees
erythematous papules/vesicles, negative for fungi
dx is _____
drugs will inhibit ___
atopic dermatitis
phospholipase A2
older man, 3m of nodule on left side of nose
lots of outdoor exposure
risk factor for condition is ___
sun exposure
elderly man, sevre pain in knee
no fever, right knee swelling/warm
TTP, dec range of motion
xray shows large subchondral cysts, meniscal calcifications
leuks elevated
aspirate shows ____
calcium pyrophosphate
elderly man, widespread bilsters, vesicles/ bullae in axillae/groin
remainder of exam is neg
dx is ____
adhesion failure occurs in __
bullous pemphigoid
basement membrane
teenager, history of pain below the knee
cannot play sports anymore
swelling/tender
dx is ___
excessive contraction of ___
osgood schlatter
quadriceps
elderly woman, post menopause, low back pain/tenderness
xray shows fracture of lumbar spine
DEXA shows dec bone mineral density
labs w/in normal ranges
dx is ____
tx w ___, which decreases ____
osteoporosis
bisphosphonates, osteoclast activity
MA man, scaly rash over wrist
recently started wearing a new watch
dx is ____
type __ HS, activation/deposition of ___
allergic contact dermatitis
3, CD8 t cells
younger boy, scaling/patchy hair loss on scalp
normal labs
infectious agent is ___
trichophyton
older woman, ulcer at base of spine
PM of cerebral infarct
pink, clear exudate from ulcer
pitting edema
muscle strength dec/sensation dec
unable to stand unassissted
ulcer caused by ___
pressure
elderly man, worsening low back pain
long history of smoking
dec breath sounds/dullness over RUL
low sodium/K
high Ca
dx is ____
cause of back pain ___
SCLC
metastatic disease
teenager, fam history of palpitations/myopia
long thin face, hyperdynamic precordium, MVP
enlarged aortic root
dx is ____
abnormal synthesis of ___
marfan syndrome
fibrillin
athlete injures knee, cannot bear weight
left knee displaces anteriorly too much
tear has occurred to ___
ACL
elderly pt, tenderness in right hip
xray shows fracture of femoral neck
dx is ___
med needed to inhibit ___
this is a ___
osteoporosis
osteoclasts
bisphosphonates
woman waking up at night, numbness/pain in right hand
shaking to dec severity
hx of excessive hand use
tenderness/tingling of wrist
tingling upon palmar flexion
dx is ____
damage has occurred to ___
carpal tunnel syndrome
median nerve
teenager, knee pain
tender mass on proximal knee
xray with mass on diaphysis
dx is ____
look for ___ pattern or ____
located in the __ of bones
usually in ___
osteosarcoma
suburst
codman triangle
metaphysis
knee
MA man, worsening low back pain
now awakens him at night, eases over course of day
tenderness to PSIS bilaterally, dec spine flexion
dx is ___
___ inflammation w formation of ____
ankylosng spondylitis
axial joint, new bone
ma woman, bilateral foot/ankle pain
worse in morning, swelling on PCP bilaterally
dx is ___
medication taken inhibits __
RA
TNF
Monoclonal ab
A/G/I/C
fusion TNF receptor E__
targets ___
molecule responsible for __/___ fxns
can treat A/C/P/R
adalimumab, golimumab, infliximab, certolizumab
etanercept
TNF
inflam/immunoregulatory
AS/Chrons/Psoriasis/RA
Receptor antagonist ___
targets ___
molecule stimulates prod of __ and ___
can treat ___
anakinra
IL1
PG/MMP
RA
monoclonal ab M/R
targets __
mediates __ recruitment and ___
used to tx ___
mepolizumab/resulizumab
IL5
eosinophil, inflammation
Asthma
Receptor monoclonal ab T
targets ___
activates T__/B__/M__/O__
used to tx __/___
tocilizumab
IL6
T cell/B cell, macros, osteoclast
GCA/RA
Monoclonal ab U
targets __/__
mediates __ of TH17 cells
useful against __/___
ustekinumab
IL12/23
inflam fxn
Chron/psoriasis
monoclonal ab S/I/B
targets ___
mediates __ of TH17 cells
tx A/P
secukinumab, ixekizumab, brodalumab
IL17
inflam fxn
AS/psoriasis
CTLA4-IgG fusion protein A__
targets ___
molecule activates ___
used to tx P/R
abatacept
CD80/86
activation of t cell
psoriasis/RA
A4B7 integrin monoclonal ab V____
inhibits ___
prevents ___ to site of inflam
tx ___
vedolizumab
integrin
leuk migration
crohns
JAK antagonist T
targets ___, inhibiting a TK mediating __ in JAK-stat pathway
used to tx P/R
tofacitinib
JAK, signal transduction
psoriasis, RA
