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Multisystem 2 > MSK review > Flashcards

MSK review Flashcards

1
Q

pt w target rash, previous hunting trip

dx is ___

at risk for ____

bacterial cause is __

A

lyme dz

carditis

borrellia bungdorfi

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2
Q

35 yr old man, 3 day history of hemoptysis and rash

multiple episodes of sinusitis

skin rash over les

dx is ___
mechanism: ___ of vasc endothelium

A

vasculitis

inflammation

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3
Q

teenager, hx of facial rash

PE shows open/closed comedones

cause of skin findings: stimulation of __ by ___

A

sebaceous glands, androgens

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4
Q

young girl, 6w of itchy rash on elbows and backs of knees

erythematous papules/vesicles, negative for fungi

dx is _____
drugs will inhibit ___

A

atopic dermatitis

phospholipase A2

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5
Q

older man, 3m of nodule on left side of nose

lots of outdoor exposure

risk factor for condition is ___

A

sun exposure

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6
Q

elderly man, sevre pain in knee

no fever, right knee swelling/warm

TTP, dec range of motion

xray shows large subchondral cysts, meniscal calcifications

leuks elevated

aspirate shows ____

A

calcium pyrophosphate

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7
Q

elderly man, widespread bilsters, vesicles/ bullae in axillae/groin

remainder of exam is neg

dx is ____
adhesion failure occurs in __

A

bullous pemphigoid

basement membrane

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8
Q

teenager, history of pain below the knee
cannot play sports anymore

swelling/tender

dx is ___
excessive contraction of ___

A

osgood schlatter

quadriceps

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9
Q

elderly woman, post menopause, low back pain/tenderness

xray shows fracture of lumbar spine

DEXA shows dec bone mineral density

labs w/in normal ranges

dx is ____
tx w ___, which decreases ____

A

osteoporosis

bisphosphonates, osteoclast activity

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10
Q

MA man, scaly rash over wrist

recently started wearing a new watch

dx is ____
type __ HS, activation/deposition of ___

A

allergic contact dermatitis

3, CD8 t cells

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11
Q

younger boy, scaling/patchy hair loss on scalp

normal labs

infectious agent is ___

A

trichophyton

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12
Q

older woman, ulcer at base of spine

PM of cerebral infarct

pink, clear exudate from ulcer

pitting edema

muscle strength dec/sensation dec

unable to stand unassissted

ulcer caused by ___

A

pressure

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13
Q

elderly man, worsening low back pain

long history of smoking
dec breath sounds/dullness over RUL

low sodium/K
high Ca

dx is ____
cause of back pain ___

A

SCLC

metastatic disease

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14
Q

teenager, fam history of palpitations/myopia

long thin face, hyperdynamic precordium, MVP

enlarged aortic root

dx is ____
abnormal synthesis of ___

A

marfan syndrome

fibrillin

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15
Q

athlete injures knee, cannot bear weight

left knee displaces anteriorly too much

tear has occurred to ___

A

ACL

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16
Q

elderly pt, tenderness in right hip

xray shows fracture of femoral neck

dx is ___
med needed to inhibit ___
this is a ___

A

osteoporosis
osteoclasts
bisphosphonates

17
Q

woman waking up at night, numbness/pain in right hand

shaking to dec severity

hx of excessive hand use
tenderness/tingling of wrist

tingling upon palmar flexion

dx is ____
damage has occurred to ___

A

carpal tunnel syndrome

median nerve

18
Q

teenager, knee pain

tender mass on proximal knee

xray with mass on diaphysis

dx is ____

look for ___ pattern or ____

located in the __ of bones
usually in ___

A

osteosarcoma

suburst
codman triangle

metaphysis
knee

19
Q

MA man, worsening low back pain

now awakens him at night, eases over course of day

tenderness to PSIS bilaterally, dec spine flexion

dx is ___
___ inflammation w formation of ____

A

ankylosng spondylitis

axial joint, new bone

20
Q

ma woman, bilateral foot/ankle pain

worse in morning, swelling on PCP bilaterally

dx is ___
medication taken inhibits __

A

RA

TNF

21
Q

Monoclonal ab

A/G/I/C
fusion TNF receptor E__

targets ___

molecule responsible for __/___ fxns

can treat A/C/P/R

A

adalimumab, golimumab, infliximab, certolizumab

etanercept

TNF

inflam/immunoregulatory

AS/Chrons/Psoriasis/RA

22
Q

Receptor antagonist ___

targets ___

molecule stimulates prod of __ and ___

can treat ___

A

anakinra

IL1

PG/MMP

RA

23
Q

monoclonal ab M/R

targets __

mediates __ recruitment and ___

used to tx ___

A

mepolizumab/resulizumab

IL5

eosinophil, inflammation

Asthma

24
Q

Receptor monoclonal ab T

targets ___

activates T__/B__/M__/O__

used to tx __/___

A

tocilizumab

IL6

T cell/B cell, macros, osteoclast

GCA/RA

25
Q

Monoclonal ab U

targets __/__

mediates __ of TH17 cells

useful against __/___

A

ustekinumab

IL12/23

inflam fxn

Chron/psoriasis

26
Q

monoclonal ab S/I/B

targets ___

mediates __ of TH17 cells

tx A/P

A

secukinumab, ixekizumab, brodalumab

IL17

inflam fxn

AS/psoriasis

27
Q

CTLA4-IgG fusion protein A__

targets ___

molecule activates ___

used to tx P/R

A

abatacept

CD80/86

activation of t cell

psoriasis/RA

28
Q

A4B7 integrin monoclonal ab V____

inhibits ___
prevents ___ to site of inflam

tx ___

A

vedolizumab

integrin
leuk migration

crohns

29
Q

JAK antagonist T

targets ___, inhibiting a TK mediating __ in JAK-stat pathway

used to tx P/R

A

tofacitinib

JAK, signal transduction

psoriasis, RA

Multisystem 2 (14 decks)

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