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Musculoskeletal Block > MSK drugs > Flashcards

MSK drugs Flashcards

1
Q

What is the maximum daily dose of paracetamol for a >60kg patient ?

A

1g up to 4x daily

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2
Q

If pain persisted or increased while being treated with a non-opioid drug, what would you move to next?

A

A weak opioid such as codeine then to morphine if pain persists or increases

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3
Q

What does NSAIDs stand for?

A

Non-Steroidal Anti-inflammatory drugs

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4
Q

What are the two core properties of NSAIDs?

A

anti-inflammatory and analgesic

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5
Q

NSAIDs inhibit _____________ (_____) a key enzyme in the formation of _____________, ______________ and ________________.

A 
Cycloxygenase
COX
prostaglandins
prostacyclins
thromboxanes
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6
Q

The therapeutic effect of NSAIDs depends on blocking ________ and their side effects come from blocking ________.

A

COX-2

COX-1

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7
Q

Give four examples of NSAIDs

A

ibuprofen
naproxen
Diclofenac
Celecoxib (COX-2 specific NSAID

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8
Q

NSAIDs are used for the treatment of which two groups of MSK issues?

A

MSK pain

Inflammatory arthritis

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9
Q

What are the two most common side effects of NSAIDs? Name three other possible side effects.

A

indigestion and skin rashes
renal impairment
Upper GI problems- peptic ulceration
increased risk of cardiovascular events and heart failure

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10
Q

What does DMARDs stand for?

A

Disease modifying anti-inflammatory drugs

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11
Q

DMARDs are ________ acting drugs taking weeks or months to have an effect. They are solely ___________ not analgesic. they improve the ___________ tests of inflammation and they slow down rate of ________ damage. DMARDs need constant ________.

A 
slow
anti-inflammatory
laboratory
Joint
Review
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12
Q

What is the first line drug used in the treatment of RA within three months of diagnosis?

A

methotrexate

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13
Q

Name four common DMARDs

A

methotrexate
sulfasalazine
Leflunomide
Hydroxychloroquine

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14
Q

What is the main contraindication for methotrexate?

A

unsafe in pregnancy

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15
Q

Sulfasalazine is used in combo with which other drug?

A

Methotrexate

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16
Q

Hydroxychloroquine is used in the treatment of which conditions?

A

RA
SLE
Sjorgen’s syndrome

17
Q

Anti-TNF therapy is ________ effective than DMARDs and is usually administered _____________. They are usually given in combination with methotrexate

A

more

subcutaneously

18
Q

Name five Anti-TNF drugs

A 
infliximab
adalimumab
Etanercept
Certolizumab
Golimumab
19
Q

Name some of the main side effects of corticosteroids

A 
centripetal weight gain
muscle wasting
skin atrophy
osteoporosis
diabetes 
hypertension

Musculoskeletal Block (10 decks)

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