Arthritis and some myopathies Flashcards
Define Neuromyotonia
A autoimmune disease involving antibodies which act against K+ ion channels. It results in hyperexcitability and therefore prolonged skeletal muscle contraction.
Identify two anticonvulsant treatments of Myotonia
Carbamazapine, Phenytoin
Lambert Eaton Myasthenic Syndrome (LEMS) is associated with what condition?
Small cell bronchial carcinoma
LEMS is associated with the defective release of what neurotransmitter?
ACh
LEMS can have autoimmune causes- Identify which channels are effected in this case
Ca2+ channels
Identify two types of drug used in the treatment of LEMS.
anticholinesterases
potassium channel blockers
Identify the cardinal sign of LEMS.
proximal muscle weakness with some absent tendon reflexes
identify the cardinal signs of Myasthenia gravis
weakness and fatigability in proximal limbs, ocular and bulbar muscles
What is targeted by autoantibodies in the autoimmune disorder Myasthenia Gravis
ACh receptor protein
Identify two types of drugs used to treat MG and an example of each
anticholinesterases- Pyridostigmine, edrophonium
Immunosuppressants- azathioprine
What bacteria produces Botulinum toxin? How does it effect ACh release?
Clostridium Botulinum
irreversibly inhibits ACh release
How do curare like compounds effect the amplitude of epp?
They reduce it below the threshold for an AP by being competitive antagonists to AChRs
10% of myasthenia gravis is caused by ____ ______ while 90% is idiopathic
thymic tumours
Describe the pathophysiology of myasthenia gravis
CD4+ T cells activated by AChRs expressed on thymic cells leading to autoreactive B cell stimulation thus the generation of auto-IgG antibodies for AChRs. AChRs are thus destroyed by the antibodies. The muscle end plate also becomes damaged
Identify the two main tests for Myasthenia Gravis
Auto-IgG antibodies in the serum
repetitive nerve stimulation- the responses gradually decrease
90% of osteomyelitis is caused by what pathogen?
Staphlococcus but also salmonella and H. Influenzae
Osteomyelitis occurs due to ____________ spread to the vascular ___________.
haematogenous
metaphysis
identify two of the conditions in which setting osteomyelitis is found
type 2 diabetes
Chronic skin ulceration ( from venous insufficiency)
_____________ osteomyelitis occurs due to haematogenous spread from the lungs/the GI tract. The __________ are often involved and may collapse and form abscesses
haematogenous
vertebrae
identify four symptoms of osteomyelitis
localized bone pain, fever, tenderness, erythema
which organism is the main cause of septic arthritis?
Staph. Aureus
in young/previously healthy patients identify how septic arthritis would present
red, hot, erythematous, swollen, agonizing pain, held immobile by muscle spasm.
in elderly/immunosuppressed/RA patients may be more insidious with few systemic symptoms
to investigate septic arthritis you would 1. aspirate the joint/get a _______ culture 2. _________ the joint 3. provide __________ 4. administer IV _________.
blood
immobilise
physiotherapy
antibiotics
What is the difference between primary and secondary osteoarthritis?
Primary-idiopathic and with old age
Secondary- due to predisposing conditions
Pathogenesis of OA:
Initial ________ _________ damage leading to surface __________ and ulceration. This causes further ________ loss putting more stress on the bones leading to ____________ and cysts. In the worst case __________ would form which are abnormal sclerotic projections of subchondral bone and they are visible on X-rays..
articular cartilage fibrillation cartilage microfractures osteophytes
explain the effect of inflammatory cytokines on OA pathogenesis.
The stimulation of macrophages and T cells by trauma of joints etc leads to the release of pro-inflammatory cytokines resulting in a disturbance to the cartilage turnover rate leading to articular cartilage degeneration.
identify 5 predisposing risk factors for OA
obesity gender- more common in women trauma sport/occupation genetic predisposition secondary causes: RA, gout, spondyloarthritis, septic arthritis
Identify 3 symptoms of OA
joint pain upon movement and/or weight bearing
functional limitation
short lived morning joint stiffness
identify 5 signs of OA
crepitus reduced movement joint effusion muscle wasting/ bony instability bone enlargement
Identify the most commonly affected sites of OA
cervical spine lumbar spine interphalangeal joints hip joint knee joint ankle great toe metatarsal
identify 5 possible investigations of OA
X-ray- shows progressive disease and is initial test
blood tests
arthroscopy- early injury
aspiration of synovial fluid
MRI-early injury- shows soft tissue involvement
Identify some non-pharmacological treatments of OA
lose weight physiotherapy walking aid hydrotherapy suitable footwear