MSK Drugs Flashcards
Aspirin
Irreversible inhibitor of COX-1 and COX-2
Short half-life
Sodium salicylate
Inhibitor of COX-1 and COX-2
Long half-life
Indomethacin
Inhibitor of COX-1 and COX-2
Short half-life
Ibuprofen
Inhibitor of COX-1 and COX-2
Short half-life
Naproxen
Inhibitor of COX-1 and COX-2
Long half-life
Phenylbutazone
Inhibitor of COX-1 and COX-2
Long half-life
Toxicity: agranulocytosis, aplastic anemia
Diclofenac
Inhibitor of COX-1 and COX-2
Long half-life
Celecoxib
Inhibitor of COX-2
Leflunomide
Immunosuppressant used to treat rheumatoid arthritis
Pro-drug
Long half-life
Teratogenic
Methotrexate
Immunosuppressant used to treat rheumatoid arthritis
Etancercept
TNF-alpha blocker used to treat rheumatoid arthritis
Infliximab
TNF-alpha blocker used to treat rheumatoid arthritis
Anakinra
IL-1 receptor antagonist used to treat rheumatoid arthritis
Alendronate
Bisphosphonate used to treat osteoporosis, Paget’s disease, metastatic bone disease
Raloxifene
Selective estrogen receptor modulator (SERM) used to great osteoporosis
Denosumab
Antibody that binds to RANKL and decreases differentiation of osteoclasts
Teriparatide
Osteoanabolic drug (active portion of PTH) that stimulates osteoblastic activity
