MSK Drugs Flashcards
Aspirin
Irreversible inhibitor of COX-1 and COX-2
Short half-life
Sodium salicylate
Inhibitor of COX-1 and COX-2
Long half-life
Indomethacin
Inhibitor of COX-1 and COX-2
Short half-life
Ibuprofen
Inhibitor of COX-1 and COX-2
Short half-life
Naproxen
Inhibitor of COX-1 and COX-2
Long half-life
Phenylbutazone
Inhibitor of COX-1 and COX-2
Long half-life
Toxicity: agranulocytosis, aplastic anemia
Diclofenac
Inhibitor of COX-1 and COX-2
Long half-life
Celecoxib
Inhibitor of COX-2
Leflunomide
Immunosuppressant used to treat rheumatoid arthritis
Pro-drug
Long half-life
Teratogenic
Methotrexate
Immunosuppressant used to treat rheumatoid arthritis
Etancercept
TNF-alpha blocker used to treat rheumatoid arthritis
Infliximab
TNF-alpha blocker used to treat rheumatoid arthritis
Anakinra
IL-1 receptor antagonist used to treat rheumatoid arthritis
Alendronate
Bisphosphonate used to treat osteoporosis, Paget’s disease, metastatic bone disease
Raloxifene
Selective estrogen receptor modulator (SERM) used to great osteoporosis