MSK Drugs Flashcards

1
Q

Aspirin

A

Irreversible inhibitor of COX-1 and COX-2

Short half-life

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2
Q

Sodium salicylate

A

Inhibitor of COX-1 and COX-2

Long half-life

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3
Q

Indomethacin

A

Inhibitor of COX-1 and COX-2

Short half-life

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4
Q

Ibuprofen

A

Inhibitor of COX-1 and COX-2

Short half-life

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5
Q

Naproxen

A

Inhibitor of COX-1 and COX-2

Long half-life

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6
Q

Phenylbutazone

A

Inhibitor of COX-1 and COX-2
Long half-life
Toxicity: agranulocytosis, aplastic anemia

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7
Q

Diclofenac

A

Inhibitor of COX-1 and COX-2

Long half-life

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8
Q

Celecoxib

A

Inhibitor of COX-2

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9
Q

Leflunomide

A

Immunosuppressant used to treat rheumatoid arthritis
Pro-drug
Long half-life
Teratogenic

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10
Q

Methotrexate

A

Immunosuppressant used to treat rheumatoid arthritis

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11
Q

Etancercept

A

TNF-alpha blocker used to treat rheumatoid arthritis

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12
Q

Infliximab

A

TNF-alpha blocker used to treat rheumatoid arthritis

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13
Q

Anakinra

A

IL-1 receptor antagonist used to treat rheumatoid arthritis

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14
Q

Alendronate

A

Bisphosphonate used to treat osteoporosis, Paget’s disease, metastatic bone disease

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15
Q

Raloxifene

A

Selective estrogen receptor modulator (SERM) used to great osteoporosis

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16
Q

Denosumab

A

Antibody that binds to RANKL and decreases differentiation of osteoclasts

17
Q

Teriparatide

A

Osteoanabolic drug (active portion of PTH) that stimulates osteoblastic activity