Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > GI Drugs > Flashcards

GI Drugs Flashcards

1
Q

Cimetidine

A

H2 blocker
Last choice H2 blocker due to side effects: drug interactions, prolactin release –> gynecomastia, reduced libido, can cross BBB and placenta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Ranitidine

A

H2 blocker

May cause headaches

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Famotidine

A

H2 blocker

May cause headaches

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Nizatidine

A

H2 blocker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Omeprazole

A

PPI

Irreversibly inhibits H+/K+ ATPase in stomach parietal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Lansoprazole

A

PPI

Irreversibly inhibits H+/K+ ATPase in stomach parietal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Esomeprazole

A

PPI

Irreversibly inhibits H+/K+ ATPase in stomach parietal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Pantoprazole

A

PPI

Irreversibly inhibits H+/K+ ATPase in stomach parietal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Dexlansoprazole

A

PPI

Irreversibly inhibits H+/K+ ATPase in stomach parietal cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Bismuth-subsalicylate (Pepto bismol)

A

Coats and provides physical protection of ulcers; antibacterial
May turn stools black

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Misoprostol

A

PGE1 analog increases production and secretion of mucus and decreases acid production
Indicated for NSAID-induced ulcers
Contraindicated in women of childbearing age (abortifacient)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Aluminum hydroxide (Maalox)

A

Antacid

Side effects include hypokalemia, constipation, osteoporosis, hypophosphatemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Calcium carbonate (Tums)

A

Antacid

May cause hypokalemia, hypercalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Magnesium hydroxide (Maalox)

A

Antacid and osmotic laxative

May cause hypokalemia, hypermagnesmia, and diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Magnesium citrate

A

Osmotic laxative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Polyethylene glycol (Miralax)

A

Osmotic laxative

17
Q

Lactulose

A

Osmotic laxative

18
Q

Infliximab

A

Monoclonal antibody to TNF-alpha
Treats Crohn, UC, rheumatoid arthritis, anklyosing sphondylitis, psoriasis
Increased susceptibility to infections, malignancy, hepatotoxicity

19
Q

Ondansetron

A

Anti-emetic

5-HT3 antagonist reduces vagal stimulation

20
Q

Metclopramide

A 
Anti-emetic and prokinetic
D2 receptor antagonist
5-HT3 antagonist
5-HT4 agonist
Increases Parkinsonian effects, hyperprolactinemia, tardive dyskinisia
21
Q

Sucralfate (aluminum sucrose sulfate)

A

Coats and provides physical protection of ulcers
Administer on an empty stomach
May reduce bioavailability of tetracyline

22
Q

Why are PPIs so effective?

A
  1. Irreversibly inhibits H+/K+ ATPase
  2. Drug is only active at low pH
  3. Protonated drug is trapped in caniculi
23
Q

Treatment for H. pylori infection

A

Metronidazole + tetracyline + bismuth subsalicylate

Clarithromycin + amoxicillin + metronidazole/tinidazole

24
Q

Aprepitant

A

Anti-emetic

NK1 receptor blocker

25
Q

Diphenoxylate

A

Anti-diarrheal
Piperidine opioid combined with atropine to prevent abuse (can enter CNS)
May cause constipation and toxic megacolon
Contraindicated in severe UC

26
Q

Loperamide (Imodium)

A 
Anti-diarrheal
Piperidine opioid
Poor penetration of CNS
May cause constipation and toxic megacolon
Contraindicated in severe UC
27
Q

Alosetron

A

Anti-diarrheal
5-HT3 antagonist
Used to treat diarrhea-predominant IBS in women

28
Q

Linaclotide

A

Stimulates secretion of chloride and bicarbonate into intestines
Indicated for constipation (including IBS)

29
Q

Lubiprostone

A 
Opens CIC-2 chloride channel
Treats constipation (including opioid-induced)
30
Q

Naloxegol

A 
Opioid antagonist (doesn't enter CNS)
Treats opioid-induced constipation
31
Q

Bisacodyl (Dulcolax)

A

Stimulant laxative

Promotes accumulation of water and salt in the colonic lumen and stimulates motility

32
Q

Senna

A

Stimulant laxative

Promotes accumulation of water and salt in the colonic lumen and stimulates motility

Pharmacology (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions