MSK and SKin Flashcards
LEMS has _muscle weakness (first) + _ symptom and _ with exercise(as opposed to MG)
LEMS has proximal muscle weakness (first) + autonomic symtoms and normalizes with exercise(as opposed to MG)
Pathogenesis of RA is via macrophage _= eternercept targets.
Pathogenesis of RA is via macrophage TNF(a)= eternercept targets.
Goodpastures vrs contact dermatis = type _ vrs type _
Wound Healing: contracture due to inc MMP + myofibroblasts activity
Ant. view of knee: ACL/PCL attach _ + _ femur condyle/
Ant. view of knee: ACL/PCL attach ant + lat femur condyle/ post + medial femur condyle
obturator artery/ medial circumflex important for child/adult because /
obturator artery/ medial circumflex important for child/adult because epiphyseal growth plate in head /main blood supply to femoral neck
Paget disease labs: all normal except _
Paget disease: all normal except Alk phosphotase
Drug induced lupus eythematosus(DILE): _antibodies more specific than anti-dsDNA -> presents in slow acetylators( procainamide)
Drug induced lupus eythematosus(DILE): Anti-histone antibodies more specific than anti-dsDNA -> presents in slow acetylators( procainamide)
Dermatomyositis has _ inflammation
Dermatomyositis has perimysial inflammation(because skin affected too)
anti-_ for crest vrs dna_ for SCL
anti-centromere( c for crest vrs dna topoisomerase for SCL)
- Alkaptouria vrs homocyteinuria=
- Alkaptouria/ homocyteinuria= homogenistic oxidase def/ methinine or cytathione syntase problem -> systemic symptoms
IL-1 and TNF-A are inflammatory cytokines(cox-_ is induced l):
celeximab ( mech selectivity inhibits cox-_)
infliximab inhib _
IL-1 and TNF-A are inflammatory cytokines(cox-2 is induced vrs cox-1 constituitional): celeximab ( mech selectivity inhibits cox-2)
infliximab inhib TNFa
Hematogenous osteomyelitis: adults/children = where -> sequestrum _ by involcrum (?)
Vertebral osteomyeliitis: recent _ predispose , _ of spine is best for imagining
Analgesics and close follow up for _issues
Hematogenous osteomyelitis: adults/children = vetebral/metaphysis -> sequestrum surrounded by involcrum = necrotic bone + overlying bone
Vertebral osteomyeliitis: recent endocarditis/bacteremia( staph) , MRI of spine is best
Analgesics and close follow up for MSK issues
_ :systemic sysmptoms + cervical _laxation( spares hips and lubosacral joints) + anti CCRP
RA: systemic sysmptoms + cervical sublaxation( spares hips and lubosacral joints) + anti CCRP
Only _ is intracellular
11 Only K is intracellular
Dermatomyositis compared to polymyo?
Dermatomyositis with malignancy(both with intersititial lung diseae)
Presentation of Strep pyo diseases do not have to be _most likely exclusive: RPGN vrs rheumatic disease
- Presentation of Strep pyo diseases do not have to be concurrent most likely exclusive: RPGN vrs rheumatic disease
anti _= anti-TRNA synthetase
anti-smooth muscle/ anti mitochondrial = autoimmune hepatitis/ PBColangitis,
anti jo= anti-TRNA synthetase
ant. cruciate sticks to _ of femur menisci does? pec anserine(gts):
- ant. cruciate sticks to ant & lat of femur pca is post & medial
menisci is shock absorber
pec anserine(gts): sat, semi tend, gracialis
WHat does not change? in sacromere
Muscle: HI = thick/thin change A= doesn’t change
Cutaneous small vessel vasculitis: leukocytoclastic(fragmented ) + lower leg nonblanching _ due to
Urticaria: transient, raised, _ due to meds; type 3 hypersensitivty
Cutaneous small vessel vasculitis:leukocytoclastic(gragmented neutrophils) + lower leg nonblanching purpura due to medications
Urticaria: transient, riased, blanchable due to meds; type 3 hypersensitivty
_ = bacitran
PYR = bacitran
- Greater sciatic and sacro spine in sacrium are _
spinal stenosis is _dependent symptoms
- Greater sciatic and sacro spine in sacrium are above
spinal stenosis is posture dependent symptoms
Methotrexate(2l /hydroxychloroquine( _)/ minocycline ( _) cause = adverse effects
Methotrexate(lung + liver) /hydroxychloroquine( eye)/ minocycline ( dermatitis) cause = adverse effects
Leukocyte adhesion deficieny due to lack of CD_
Leukocyte adhesion deficieny due to lack of CD18
golgi tendon organ vrs muscle spindle system ?
golgi tendon organ vrs muscle spindle system regulate force/ lenght
PPI’s lansoprazole can cause _, _ infect
colchicine adverse effects: _ upset
diltiazem, Escitalopram
PPI’s lansoprazole can cause osteoporosis
colchicine adverse effects: GI upset(diarrhea)
Acne presents as ?
_ used is a know cause in atlethes
Acne presents as comedomal eruptions; anabolic steroid used is a know cause in atlethes
Acne is inflammatory disorder of _ follicles with _keratinization of follicles->sebaceous gland _>sebum secretion-> by propion bacteria
Acne is inflammatory disorder of pilosebaceous follicles with hyperkeratinization of follicles->sebaceous gland enlargement>increased sebum secretion->colonization by propion bacteria
treatment for psoriasis: topical _ & vit _ which inhib cell proliferation & stimulate differentiation
treatment for psoriasis: topical coticosteriods & vit D which inhib cell proliferation & stimulate differentiation
compound nevi is in both _ so _ but not melanoma
compound nevi is in both epidermis & dermis so invasive but not melanoma
acne risk factors: _(steroid type) pilosebaceous glands obstruction by oil based products, _irritation of follicules, _ paticipation
acne risk factors: androgens, pilosebaceous glands obstruction by oil based products, mechanical irritation of follicules, sports paticipation
Actinic keratosis different from psoriasis on picture how?
scaly erythematous lesions with keratinocyte atypia, hyperkeratosis and parakeratosis with sand-paper like texture vrs thick white silvery scale
Vitiligo is due to _of epidermal melanocytes, looks like?
Vitiligo is due to loss of epidermal melanocytes, looks like?
How does sports participation trigger acne?
How does sports participation trigger acne: via used of tight-fitting clothing and protective gear
Scabies: _ infection with excoriations and burrows _; presents with impaired _-mediated immunity; treat with _ or ivermectin
Scabies: mite infection with excoriations and burrows rash; presents with impaired cell-mediated immunity; treat with permethrin or ivermectin
Foreign bodies elicit _ response.
Foreign bodies elicit granulomatous response.
Supracondylar fractures may damages 3 thing under what conditions? lateral/medial displacement of proximal fracture seg?
Supracondylar fractures may damages 3 thing under what conditions? lateral/medial displacement of proximal fracture seg? Radial nerve/median nerve & brachial artery
Another name for flexure retinaculum?
Another name for flexure retinaculum? Transverse carpal ligament
Osteomyelitis? Bone infection. Most common bacteria 3 (child, sickle cell, pot, diabetes, impaired mobility, surgery)?
Osteomyelitis? Bone infection. Most common bacteria (child, sickle cell, pot, diabetes, impaired mobility, surgery)? staph ->strep, salmonella
Direct inguinal due to weakness of what ? In what triangle? Borders
Direct inguinal due to weakness of what ? In what triangle? Borders
Transversalis fascia, hasselbach, rectus abdominus& epigastric vessels( med & lat)
MM on BM aspirate?
>_Plasma cell with _nuclear paleness(golgi) and clockface
MM on BM aspirate?
>10% Plasma cell with perinuclear palenss(golgi) and clockface
Psoa is where?
Psoa is here? Psoas is at the veterbra, illacus is at the illac crest.
