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Asem > C5 > Flashcards

C5 Flashcards

1
Q

Chronic ->(new onset phagia)->(healed ulcers when collagen fibers contract)

A

Chronic Gerd->ulceration(new onset odynophagia)->strictures(healed ulcers when collagen fibers contract)

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2
Q

How differentiate between SMA and celiac trunk?

A

How differentiate between SMA and celiac trunk?

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3
Q

_ infection causes gingiovostimatitis

A

1409 virus! HSV infection causes gingiviostomatitis

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4
Q

_ abortion: due to _ + _: foul-smelling _ , fever, pain, tenderness

A

Septic abortion: due to g-neg bacilli(e coli) + staph; foul-smelling tissue, fever, pain, tenderness

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5
Q

Alcohol abuse maifest (3): _( can be independent of _ deficiency )+ acute pancreatitis( / > 2)

A

Alcohol abuse: macrocytosis( can be independent of folate deficiency )+ acute pancreatitis( AST/ALT > 2)

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6
Q

Atrophic _ treatment with b12: reticulocyte count _ dramatically(peak _ wk) then tapers off (hg, erythrocyte counts / methylmalonic acid gradually(8wks) _/ _)

A

Atrophic gastritis treatment with b12: reticulocyte count increases dramatically(peak 1 wk) then tapers off (hg, erythrocyte counts / methylmalonic acid gradually(8wks) in/ dec)

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7
Q

_ is _ crescent shaped( parasite); hallmark is chorioretinitis(retinal _)

A

Toxo is intracellular crescent shaped( parasite); hallmark is chorioretinitis(retinal lesions)

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8
Q

_ disease: person who gets erythema _(rash) then _ with AV _ which may present with dyspea & syncopy

A

Lyme disease: person who gets erythema migrans(rash) then carditis with AV block which may present with dyspea & syncopy

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9
Q

Fungal Cell membrane(3)/ cell wall inhibitors(1) = [(_ &)/ / ergosteral in membrane]/ Echinocandin(_) inhibs synthesis of _in wall

A

Fungal Cell membrane/ cell wall inhibitors = [(ampho & nystatin)/azoles bind/inhib synthesis of ergosteral in membrane]/ Echinocandin(caspofungin) inhibs synthesis of glucan in wall

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10
Q

Metronidazaole + _ can cause disulfiram-like effects( due to acetaldehyde accumulation) such as headaches, cramps, nausea

A

Metronidazaole + alchol can cause disulfiram-like effects( due to acetaldehyde accumulation) such as headaches, cramps, nausea

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11
Q

Syphillis testing:
RPR & VDRL abs to _
TP-EIA, FTA-abs to _
non/specific?

A

Syphillis testing: nontreponemal RPR&VDRL/treponemail TP-EIA, FTA-abs are ab to cardiolipin-cholestrol-lectin antigen/ trepenemal ag are non/specific

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12
Q

Systemic mastocytosis: _ mutation, abnl proliferation of mast cells-> inc _ and it’s effect

A

Systemic mastocytosis: Kit mutation, abnl proliferation of mast cells-> inc histamine and it’s effect

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13
Q

Cimetidine inhibits _ receptor

A

Cimetidine inhibits H2 receptor

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14
Q

_ can treat gastroperesis (occurs in chronic _) via motilin receptor agonist (if metocloproamide(D2 @ _ does not work)

A

Erythromycin can treat gastroparesis (occurs in chronic diabetics) via motilin receptor agonist if metocloproamide(D2 @ antagonist does not work)

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15
Q

P.aeruginosa: g-neg _ oxidase _

cef_ + cef_ to treat

A

P.aeruginosa: g-neg rod oxidase + ceftazidime & cefepime treat

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16
Q

Aspergillus fumigatus:

asthma/ pre-exciting lung cavity = _/ _ colonization: mycetoma which may cause _ and shifts with _

A

Aspergillus fumigatus: asthma/ pre-exciting lung cavity = ABPA/ fungus ball colonization: mycetoma which may cause hemoptysis and shifts with position

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17
Q

C.diptheria antitoxin are _ Ig_ antibodies

A

C.diptheria antitoxin are neutralizing IgG antibodies

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18
Q

Toxic megacolon is complication of _ diagnostic: _

A

Toxic megacolon is complication of ulcerative colitis diagnostic: X-ray

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19
Q

Diagnose Strongyloides stercoralis? _ in stool, hyperinfection syndrome especially if _)

A

Diagnose Strongyloides stercoralis? larve in stool, hyperinfection syndrome especially if immunocompromised)

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20
Q

Diagnose Tapeworms(fair scene)/ Schitosomiasis = / in stool

A

Diagnose Tapeworms(fair scene)?/ Schitosomiasis = proglottids in stool/ parasite eggs in stool

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21
Q

Cord factor ?

is a virulence of _ via inhib ___ -> caseating granulomas

A

Cord factor (surface glycolipid that allows serpentine cord growth) is a virulence of m.tb via inhib macrophage phagolysoms acidification -> caseating granulomas

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22
Q

Hep C treatment: DAA inhib rep & assembly= ledipasvir mech?
sofosbuvir mech?
and simeprevir mech?

A

Hep C treatment: DAA inhib rep & assembly= ledipasvir(NS5A inhib prevent rep & assembly) and sofosbuvir( RNA dependent RNA polymeras inhib) and simeprevir ( protease inhibitor)

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23
Q

Indirect=_ bilirubin;

haptoglobin bind free hemoglobin in blood for reuptake so if hemolysis, _ haptoglobin in blood.

A

Indirect=unconjugated bilirubin; haptoglobin bind free hemoglobin in blood for reuptake so if hemolysis, low haptoglobin in blood.

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24
Q

_: US then nuclear medicine hepatobiliary scanning for diagnosis

A

Cholescystitis: US then nuclear medicine hepatobiliary scanning for diagnosis

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25
Q

Vancomycin _ occurs after prolong use: Slight / profound hypoperfusion causes _/ _ with hyaline casts/ waxy casts.

A

Vancomycin ATN occurs after prolong use. Slight / profound hypoperfusion causes Prerenal azotemia/ ischemic ATN with hyaline casts/ waxy casts.

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26
Q

Primaquine added to treatments for_hypnozote which are responsible for _

A

Primaquine added to treatments for liver hypnozote which are responsible for relapses

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27
Q

Hep D infectivity?

A

Hep D infectivity: needs to be coated by HepB surface antigen before can infect

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28
Q

_ & splenic flexture are watershed area(sigmoid & superior rectal artery)

A

Rectosigmoid & splenic flexture are watershed area(sigmoid & superior rectal artery)

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29
Q

Short bowel syndrome: resection of bowel ->post prandial voluminous _ and weight loss due to _, might have _ deficiency

A

Short bowel syndrome: resection of bowel ->post prandial voluminous diarrhea and weight loss due to malabsorpition, might have vitb12 deficiency

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30
Q

.
Acute intermittent porphyria? PBGD, 5 p’s ( GI & neuro symptoms with _ urine (reddish-brown), _ precipitate); _ + _ treats by downregulating ALAS (cyp450 inducers upregulate)

Porphyria cutanea tarda (UPD, photosensitive, dorm, _ & _(disease) induce)

Lead poisoning (ezy) 
Lead poisoning has _ lead lines and in _(pop)
A 
Porphyrias do not have basophilic stippling
Lead poisoning has blue lead lines and in miners. 
Acute intermittent porphyria? PBGD, 5 p's ( GI & neuro symptoms with portwine urine (reddish-brown), drugs precipitate);   glucose +heme treats by downregulating ALAS (cyp450 inducers upregulate)
Porphyria cutanea tarda (UPD, phosensitive, dorm, alcohol & hep C)
Lead poisoning (Alad & Ferrochelase, both)
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31
Q

Chancroid is total opposite of chancre?

Granuloma inguinale is opposite of chlamydia Lympho?

A

Chancroid is total opposite of chancre: multiple, painful, gray to yellow ragged border base
Granuloma inguinale is opposite of chlamydia Lympho: intracytoplasmic cysts without lymphadenopathy

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32
Q

Aminoglycosides resistance via modifying _ (prevent binding to 16 S)

A

Aminoglycosides resistance via modifying antibiotic (prevent bidnign to 16 S)

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33
Q

Urticaria due to IgE mediated degranulation of _ cell->superficial dermal _

A

Urticaria due to IgE mediated degranulation of mast cell->superficial dermal edema

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34
Q

HNPCC occurs at y_ age ; dorminant mismatch repair genes mutations; extraintestinal cancers( like _)

A

HNPCC occurs at young age < 50; dorminant mismatch repair genes mutaions; extraintestinal( like beast cancer) cancers

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35
Q

Kayser-fleishcer rings (look like?) on _examination,
ATP7B _ secretion into bile->cu leaks from damage hepatocytes; _Ceruloplasmin;
_ ( ZN, d-pencillamine, trientine):

basal ganglia _

A

Kayser-fleishcer rings (look like?) on slit lamp examination, ATP7B dec secretion into bile->cu leaks from damage hepatocytes; low Ceruloplasmin; chelators( ZN, d-pencillamine, trientine): Wilson disease
Wilson disease: KF rings and basal ganglia atrophy

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36
Q

MAC( mycobacterium avium complex) infect CD4

A

MAC( mycobacterium avium complex) infect CD4 <50 with nonspecific symptoms and granulomas. Treat with azithromycin

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37
Q

SS_ RNA sense _ molecules are infectious(others no because must be like human RNA)

A

SS+ RNA sense purified molecules are infectious(others no because must be like human RNA)

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38
Q

Measels ? 4 C ;

kolpik spots are tiny _lesion on buccal mucosa

A

Measels ? 4 C ; kolpik spots are tiny white/blue-gray lesion on buccal mucosa

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39
Q

Reticulocytes has _ which gives it blue color

A

Reticulocytes has residual rRNA( not nucleus) which gives it blue color

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40
Q

Candida germ tubes(ture hyphae from yeast) look like ? vrs polysacaride capsule in c.neoformis?

Candida due to thrush (2), vaginal(3) , cutaneous( 1)

A

Candida germ tubes(ture hyphae from yeast) look like ? Candida due to thursh (diabetes, antibotics), vaginal(contraceptive or antibiotics or diabetes) , cutaneous( infant diaper rash) …vrs polysacaride capsule in c.neoformis?

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41
Q

Mallory-Weiss syndrome: _ mucosal tears at GE jucntion due to inc in _( ie retching ); _predispose; account for _ of upper GI bleed.

A

Mallory-Weiss syndrome: linear mucosal tears at GE jucntion due to inc in abd pressures( ie retching ); alchohol predispose; account for 10% of upper GI bleed.

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42
Q

Anal fissure occur in _ midline due to _ blood flow

A

Anal fissure occur in posterior midline due to dec blood flow

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43
Q

Hemachromatosis looks like _ pigment within hepatocytes + _ fibrosis ( all accumulations have this)

Hepatitis looks like _ infiltrate around _

A

Hemachromatosis looks like brown pigment within hepatocytes + periportal fibrosis ( all accumulations have this)
Hepatitis looks like inflammatory cell infiltrate around periportal

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44
Q

Celiac malabsorption(ADECK)->vit _ deficiency(ricket/ osteomalacia) -> _Ca + phos -> vit D

A

Celiac malabsorption(ADECK)->vit D deficiency(ricket/ osteomalacia) -> low Ca + phos ->hi vit D

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45
Q

T-cell ALL vrs B cell All? Markers? While B-cell is most common, T cell ALL presents as _ mass that may _ things(dysphagia, SVC syndrome, respiratory syndrome);
CD2-8= _ cell; cd10 _cell

AML M4&5/M6/M7= monocytes/ erythroid precursors & elderly /megakaruoblast t(1:22) & down syndrome

A

T-cell ALL vrs B cell All? Markers? While B-cell is most common, T cell ALL presents as mediastinal mass that may compress things(dysphagia, SVC syndrome, respiratory syndrome); CD2-8= T cell; cd10 B………AML M4&5/M6/M7= monocytes/ erythroid precursors & elderly /megakaruoblast t(1:22) & down syndrome

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46
Q

Neiserra meningitis most important virulence factor for disease severity?_

LOS/capsular polysac & iga protease does

A

Neiserra meningitis most important virulence factor for disease severity? LOS; LOS/capsular polysac & iga protease = endotoxin, sepsis/ resist phago, complements, Ig

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47
Q

_(disease) associated with EBV lymphomas

A

HIV( not smoking) associated with EBV lymphomas

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48
Q

Gardos channel blockers can treat _ via prevent via

Y-glutamyl transferase? marker for?

A

Gardos channel blockers can treat SS via prevent efflux of K&h2o from cell->less dehydrate->less sickle
Y-glutamyl transferase? asses hepatic or bony origins of hi alk phos

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49
Q

Hitoplasma capsulatum presents with_ infection that spread to_ system and show _ that over time; typically discovered as multiple calcifications

A

Hitoplasma capsulatum presents with pulm infection that spread to reticuloendothelial system and show graumlomas that calcify over time; typically discovered incidentally as multiple calcifications

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50
Q

Hep B life cycle?

A

Hep B life cycle? Partially double-stranded DNA transcribed to single-standed + RNA then via revers transcriptase-> partially double stranded DNA progeny.

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51
Q

Causes of acute pancreatitis 3?

A

Causes of acute pancreatitis 3? Alcohol, gallstones, triglycerides( if more than 1000)

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52
Q

R/l/rectosigmoid colon cancer present? :

A

R/l/rectosigmoid colon cancer present? : occult bleed->fatigue/ obstruction->constipation/ hemachezia

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53
Q

p.aeruginosa is motile yes or no?

A

p.aeruginosa is motile

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54
Q

Immunologic Candida defense local vrs systemic? HIV vrs neutropenic patients?

A

Immunologic Candida defense local vrs systemic? HIV vrs neutropenic patients? Local/systemic = lymphocytes/ neutrophil so HiV/ neutropenic patients have local vrs systemic candida infections

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55
Q

Methrotrexate therapy can be used of RA(t/F?)

side effect?

A

Methrotrexate therapy can be used of RA(t/F?) side effect? Neural tube defects.

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56
Q

HIV pol/ env gene mutation cause?

A

HIV pol/ env gene mutation cause? Resistance to antiviral therapies so( consistent and combination use prevents this)/ escape from host neutralizing antibodies. Typically viral/bac mutation are for their benefits( gain resistance against therapies).

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57
Q

What does F8 do in cloting cascade? Emicizumab treat? Mech?

A

What does F8 do in clothing cascade? Emicizumab treat? Mech? Hemophilia A via micmic F8 activity(bind F9a & 10 -> 10a) -activated FA start common path

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58
Q

How does HIV infection of cell happen via binding to 2 thing?
maraviroc/efuvertide mech?

A

How does HIV infection of cell happen via binding to 2 thing? Gp120 binds both CD4 & CCR5/4 (chemokine receptor)—maraviroc/efuvertide both work inhibiting pg120/41 binding to CCR

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59
Q

Ricketssia present? Treat?

A

Ricketssia present? Treat? Appalachian Mountains, erythematous maculopap rash (aka RMSF, doxycycline

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60
Q

PML on histology? Translocation?

A

PML on histology? Translocation? Blasts, auerrods( in an AML forms)

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61
Q

If coinfect with 2 viral strains and change but progency is unchanged?

A

If coinfect with 2 viral strains and change but progency is unchanged? Phenotypic mixing(as opposed to reassortment which goes to progey)

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62
Q

Helmet and burr cells look like? Indicate what?

A

Helmet and burr cells look like? Indicate what? are schzocytes and point to mechanical damage to rbc or microangiopathic hemolytic anemia

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63
Q

Neomycin drug class?

A

Neomycin drug class? Aminoglycoside

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64
Q

Fidaxomicin? Similar to? Mech? Treats? is like a _ why? Inhib _ uniit of RNA poly; c. diff

A

Fidaxomicin? Similar to? Mech? Treats? is like a macrolide why? Bacteriacidal Inhib sigma unit of RNA poly; c. diff

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65
Q

_ poisoning from( 2)? present? Treat? Insecticide, contaminated water. Garlic odor.inhib. Dimercaprol

A

Arsenic poisoning from? present? Treat? Insecticide, contaminated water. Garlic odor.inhib. Dimercaprol

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66
Q

Methemoglobinema present? Treat? _ colored skin, chocolate blood, methylene blue to _

CaNa2EDTA/deferoxamine for what toxicities?

A

Methemoglobinema present? Treat? Gray or blue skin, chocolate blood, methylene blue
CaNa2EDTA/deferoxamine for what toxicities? Lead/iron

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67
Q

Myeloproliferative vrs leukemia labs?

A

Myeloproliferative vrs leukemia labs? Erythrocyte and platelet counts.!

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68
Q 
Dengue virus(RNA) presents in endemic area with + pain + _ fever
secondary infection with diff serotype _
A 
Dengue virus(RNA) presents in endemic area with retro-orbital pain + break-bone fever
secondary infection with diff serotype worse.
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69
Q

AML(auer rods, _ for ALL) on peripheral smear vrs. atypical lymphocytes on histology?

A

AML(auer rods, TDT for ALL) on peripheral smear vrs. atypical lymphocytes on histology? Blast & auer rods vrs not.

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70
Q

Hookworms transmition? Causes?

A

Hookworms transmition? Causes? larve in human feces in soil->through feet(transient skin rash)->lungs->coughed into GI->aldult in small intestine feed on human blood->iron deficiency anemia

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71
Q

Diphyllobothriasis has _ opening(operculum),

Toxco is via dog/cat round _ and is granulomatous,

lymphatic filariasis is worm wuchereria that attacks lymphatics causing _

A

Diphyllobothriasis has lid-like opening(operculum), Toxco is via dog/cat round worms and is granulomatous, lymphatic filariasis is worm wuchereria that attacks lymphatics->lymphadema

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72
Q

Polycistronic? regulated by a _promoter, operator and set of reg element)

A

Polycistronic(mrnas code produces multiple proteins synchronimously-ex is lac operon is regulated by a signle promoter, operator and set of reg element) vrs alt spliting in pro/eukarya

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73
Q

NSCLC and CML are similar in that both mutations are _ genes.

A

NSCLC and CML are similar in that both mutations are fusion genes.

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74
Q

spyhillis: conduloma lata()-> then gumma(): necrotizing _; neurospyhillis can occur at _ stage of the disease

A

spyhillis: conduloma lata(2nd)-> then gumma(teritary): necrotizing granulomas; neurospyhillis can occur at any stage of the disease

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75
Q

klebsiella granulomatis: STI present with _ inguinale with _ shaped intracytoplasmic indusions(Donovan bodies) in cells.

A

klebsiella granulomatis: STI present with granuloma inguinale with rod shaped intracytoplasmic indusions(Donovan bodies) in cells.

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76
Q

Tratuzumab blocks HER2 a _R

A

Tratuzumab blocks HER2 a TKR

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77
Q

Methrotrexate( can treat _ pregnancy) mec? what accumulates ?

A

Methrotrexate( can treat ectopic pregnancy) prevent THF making via inhib DHF reductase folic + DHF polyglutamate accumates

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78
Q

folinic acid is leucovorin_ from methrotrexate).

Folinic is not same as folic acid

A

folinic acid is leucovorin(rescue from methrotrexate) not folic acid

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79
Q

sulfonamides work against bacteria and not humans because ?

A

sulfonamides work against bacteria and not humans because humans lack dHP( PABA –>folic acid)

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80
Q

LMWH/ unfractioned heparin= FX / + F2 inactivation via AT3 Heparin for _ prevention.

A

LMWH/ unfractioned heparin= FX / + F2 inactivation via AT3 Heparin for DVT prevention.

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81
Q

Duodenal/jejunal/colonic intestinal atresias= causes? looks like? associations

A

Duodenal/jejunal/colonic intestinal atresias= recanalization failure wk 8/ due to vascular(SMA) injury(->absent part!)/ unkown= double-bubble/ apple-peel/ distented abd = assoc with downs/ gastroichisis/hirchspriungs

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82
Q

Nuero cysticerosis in _ americans( t. solium _) presents with _ with cysts & scolex in brain

so eggs/cyst->/ infection)

toxo if immunocompromised or congential

A

Nuero cysticerosis in central americans( t. solium pork) presents with seizures with cysts & scolex in brain( so eggs/cyst->cysticosis/tape worm infection)… toxo if immunocompromised or congential

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83
Q

Spore forming bacterias survive _ boiling temperatures.

A

Spore forming bacterias survive high boiling temperatures.

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84
Q

What infected predisposed to anal/cervical carcinoma? .

A

What infected predisposed to anal carcinoma? HIV men/women predisposed to develop anal/cervical squamous cell carcinoma because HIV increases prevalence of high risk HPV infection.

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85
Q

_ is a spirochete(corckscrew) gotten from _ contaminated with animal _ presents with illness and conjunctival_ that may go on to / failure.

A

Leptospirosis is a motile spirochete(corckscrew) gotten from water contaminated with animal urine presents with flu-like illness and conjunctival suffusion that may go on to renal/hepatic failure.

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86
Q

_ is papulo-ulcerative eschar + flu-like illness and lymphadenopathy

A

Tularemia is papulo-ulcerative eschar + flu-like and lymphadenopathy

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87
Q

Yersinia: bubonic plaque ( _-onset like intense _ +) a coccobaciili

A

Yersinia: bubonic plaque( sudden, flu-like, intense pain and lymphadenopathy) a coccobaciili

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88
Q

Rabies is via bats,

A

Rabies: via bats,

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89
Q

Villous adenoma can cause _ diarrhea with hypoproteinemia and hypokalemia

A

Villous adenoma can cause secretory diarrhea with hypoproteinemia and hypokalemia

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90
Q

An anaplastic tumour(aka pleomophinc) ?

A

An anaplastic tumour(aka pleomophinc) is not well differentiated( looks absolutely not like original tissue)

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91
Q

Hemochromatosis: iron transport physio?

_ ->Feroportin, HFE bound to transferrin recepter

A

Hemochromatosis: iron transport physio: DMT->Feroportin->HFE bound to transferrin recepter is sensor-> low hepcidin

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92
Q

Which is least suceptible to occlusion due to dual blood supply?
most bld flow/oxygen?

Warfarin coagulator & anticoagulators?

CYP450 inducers (3) & inhibitors( 2) = dec/_ metabolites (warfarin, cyclophos, statin) effect because cyp450 clears it.

A

Dual blood supply-> least suceptible to occlusion infaction : liver(if not transplant)->brain
most bld flow/oxygen= brain/ heart
Warfarin coagulator & anticoagulators
CYP450 inducers (rifampin, phenytoin, phenobarbital) & inhibitors( antifungals, antibiotics) = dec/inc metabolites (warfarin, cyclophoh) effect because cyp450 clears it.

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93
Q

All newborns should receive Vit K( if deficient_ may occur with signs of in ICP)

A

All newborns should receive Vit K( if deficient ICH may occur with signs of in ICP)

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94
Q

Esophageal manometry for achalasia shows _ LES pressure( eso strictures can’t be seen on manometry)

A

Esophageal manometry for achalasia shows inc LES pressure( eso strictures can’t be seen on manometry)

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95
Q

Foscarnet can chelate cal -> nephro_ wasting

A

Foscarnet can chelate cal -> nephro mg wasting

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96
Q

HIV attach/fusion via gp_/ gp_

A

HIV attach/fusion via gp120/ gp41

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97
Q

Typhoid fever: 3 phases( - dissociate -> rose spots( in billary tree)->bloody _)

A

Typhoid fever: 3 phases( pulse temperature dissociate -> rose spots( in billary tree)->bloody diarrhea)

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98
Q

Common intraabdominal are anerobes( so _& _ treat)=

A

Common intraabdominal are anerobes( so metro & clindamycin)= (b fragilis, enterococci, streptococi, e.coli)

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99
Q

Pure red cell aplasia caused by (2)?

_virus (_pronomoblasts) or (thymic tumor, leukemia, lymhomas)( with _ )

A

Pure red cell aplasia caused by parvovirus (gaint pronomoblasts), antibodies (thymic tumor, leukemia, lymhomas)

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100
Q

Antimalarials are not for _ deficiency people cause causes hemolytic anemia.
supravital stain is for _ bodies->G6PD deficiency

A

Antimalarials are not for G6PDH deficiency people cause causes hemolytic anemia. supravital stain is for heinz bodies->G6PD deficiency

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101
Q

Thrombotic thrombocytopenic purpora from low _->vWF _cleaved

A

Thrombotic thrombocytopenic purpora from low ADAMTS13->vWF uncleaved

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102
Q

PML is _ enhancing white matter lesion

A

PML is no enhancing white matter lesion

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103
Q

. Listeria is an intra or extra organism

A

. Listeria is an intracelluar organism

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104
Q

Aminoglycosides cause _ & _toxicity

A

Aminoglycosides cause ototoxicity & nephrotoxicity

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105
Q

30S inhib are 2

A

30S inhib are aminoglyc & tetracycls

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106
Q

Bacterial Vaginois ( is loss of _ -> overgrowth of _(so _also treats))

A

Bacterial Vaginois ( is loss of lactobacillis -> overgrowth of anaoerobes(so clindamycin also treats))

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107
Q

Clavulanic acid, sulbactam and tazobactam are ?

A

. Clavulanic acid, sulbactam and tazobactam are beta-lactamases inhibs
Clavulanic acid vrs cilastin = amoxicillins/ monobactams
NNRT’s are nevirapine & elfavirenz

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108
Q

_are nevirapine & elfavirenz

A

NNRT’s are nevirapine & elfavirenz

109
Q

. leukoplaqua = not/scrap off ?

A

. leukoplaqua = not/scrap off = malignancy or Hairly cell leukemia( EBV in HIV or transplant)/ thrush

110
Q

initial genital ulcers painful(2, multiple) =

A

initial genital ulcers non/pain(2, multiple lesions) = spyhilis & clam & klebsiella / hsv & haemophilic ducreyi(deeper)

initial genital ulcers painful(2) = hsv & haemophilic ducreyi(deeper)

111
Q

Kaposi sarcoma lesions on skin + _tract

A

Kaposi sarcoma lesions on skin + GI tract

112
Q

Thayer-Martin media?

_triad: polyartherities, rash, tenosynovitis

A

Thayer-Martin media is chocolate agar infused with anitbiotics( if anybacteria grown of shit ton of antibiotics mostl likely for n.gono)
N.gono triad: polyartherities, rash, tenosynovitis

113
Q

/ & _/ _ transfered by Anopheles/ Andes/ isodiis tick

A

malaria/dengue & chikungua/ babesiosis transfered by Anopheles/ Andes/ isodix tick

114
Q

cephalosporin resitance: 4

A

cephalosporin resitance: listeria, atypicials, MRSA, Enterococi

115
Q

/ HSV= all/ only perioral vesicles.

A

Acute/latent HSV= all/ only perioral vesicles.

116
Q

Anaplylactic vrs septic shock= ?

A

Anaplylactic vrs septic shock= atopic reaction vrs spread of bacteria shock. So echinococcus which is a parasite ->anaplylactic with Ige !!!

117
Q

_ vrs _= crossover of dsDNA/ must be segmented

A

recombination vrs reassortment= crossover of dsDNA/ must be segmented

118
Q

HSV/ EBV is within _( latent is asymptomatic)

A

HSV/ EBV is within neuronal (peripheral but neuronal)/ latent infection is asymptomatic

119
Q

_ virus looks like..multinucleated giant cells

A

HSV genital ulcer looks like..multinucleate giant cells

120
Q

If treat staph aureus abscess with oral antibiotics recurrent mean?.

A

If treat staph aureus abscess with oral antibiotics recurrent due to colonization of ant nares.

121
Q

Ethambutol/rifampin mech? side effects(1/2) ?

A

Ethambutol/rifampin mech? arabinosyl transferase/ Rnal poly inhibition. side effects(1/2) ? optic neuropathy/ rash & red-orange body fluids

122
Q

HepB vaccine immuity if of HBs ag?

A

. HepB vaccine immuity if of HBs ag? so how does this give immunity? by making antihbs that bind to s ag and prevent infection

123
Q

s/c antibodies present if

SPE/CES = ag/ ab = acutely infected-> high infectivity/ ever infeced, core period/ low infectivity/ immunity or recovery

A

s/c antibodies present if acute infection/ ever infected. .

SPE/CES = ag/ ab = acutely infected-> high infectivity/ ever infeced, core period/ low infectivity/ immunity or recovery

124
Q

_/ / = env/ phage/pilis

A

Transfromation/ duction/conjugation = env/ phage/pilis

125
Q

_ toxin tranmitted by bacterialphage to make toxic strain

A

. C. dip toxin tranmitted by bacterialphage to make toxic strain

126
Q

ESBL get resistance from?

A

. ESBL get resistance from? beta lactamases transfered through plasmids

127
Q

Hand foot and mouth disease vs herpangia?

A

Hand foot and mouth disease vs herpangia? HFMD/Herpangia = ulcerations in HF&M/ mouth muscoa only.

128
Q

_ from mosquitoes with alpha virus with fever, rash + severe polyarthrialgias

A

Chikungunya from mosquitoes with alpha virus with fever, rash + severe polyarthrialgias

129
Q

Gp 160 ->gp_ +_ bind 2

gag, pol, env genes for ?

A

Gp 160 ->gp120 + 41 bind CD4
gag, pol, env genes for ? p24/ reverse transcriptase/ gp160/= capsule(core proteins)/ protease( + RT + integrases)/ infection(so only one glycosylated cause allows low immune detect)

130
Q

_ virus is _RNA kills neural progenitor cells leading to microceph, _thinning( ventriculomegaly)

A

Zika virus is ssRNA kills neural progenitor cells leading to microceph, cortical thinning( ventriculomegaly)

131
Q

congenital _ is sensory deficits + blue berry muffin rash, jaundice

A

congenital CMV is sensory deficits + blue berry muffin rash, jaundice

132
Q

congenital _ limb hypoplasia + scar + blindness

A

congenital VZV limb hypoplasia + scar + blindness

133
Q

Cyptococcus/sporidum = meningitis/ diarhea (spores->cysts

A

Cyptococcus/sporidum = meningitis/ diarhea(spores->cysts

134
Q

Clostridium speticum if _ gas gangrene( mostly from GI _)

A

. Clostridium speticum if spontaneous gas gangrene( mostly from GI cancer) becuase a GI bacteria so

135
Q

Acute phase reactants dec(3)
procalcitonin _ bac infection
.

A

. Acute phase reactants dec(3) = prealb(transthyretin), alb, transferin,
procalcitonin inc/dec if bac/virus infection
ESR increases because more things in bld so takes more time for RBC to settle.

136
Q

Multiple ring enhancing lesion in HIV(aids defining illnesses)

A

Multiple ring enhancing lesion in HIV(aids defining illnesses)= toxo

137
Q

C1INH deficiency represents?

A

C1INH deficiency : C1INH inhibs c1 and inhibs making of bradykinin so def -> clots + angioedema.

138
Q

Can get cynobacteria from _ too!

A

Can get cynobacteria from imigrants too!

139
Q

Infectious mono atypical lymphocytes in blood smear are CD _

A

Infectious mono atypical lymphocytes in blood smear are CD 8+(EBV virus infects pharyngeal mucosa & tonsil crypts(->sore throat & lymphadenopathy) infects B cells(via CD21) and T cells hyperplase to react.

140
Q

vWF deficiency is what type of bleeding?

A

vWF deficiency is what type of bleeding? a muscoal bleed-nose, gingival, vagina. (mucosa/internal = superficial/deep tissue bleed= platelets/clotting factors.

141
Q

Iron deficiency anemia not just due to iron def but also _

A

Iron deficiency anemia not just due to iron def but also bleeds

142
Q

uremic platelet dysfunction-_ defect

A

uremic platelet dysfunction-qualitative defect

143
Q

Heparin affects Ptt or pt?

A

Heparin/warfirin affects inc pt only/pt + ptt only

144
Q

What type of heparin is best for inactivating thrombin?

A

What type of heparin is best for inactivating thrombin? unfractioned heparin/LMWH= inhib FX + F2 = FX inhib via antithrombin + equal/lesser thrombin inhib

145
Q

fondaparinux inhib_;

enoxaparin is a _

A

fondaparinux inhib FX; enoxaparin is a LMWH

146
Q

APL? treat?
t(12,21)/CD5/Auer rods/ t(15, 17)/ t(9, 22)=marker for?
t(14,18/11/ 8)= what lymphoma

A

APL? treat?
t(12,21)/CD5/Auer rods/ t(15, 17)/ t(9, 22)=All/CLL/AML/ APL//CML/
t(14,18/11/ 8)= Bcl follicular lymphoma/ marginal cell /cmyc burkit others?

147
Q

Hemachromatosis due to HFE protein inactivating mutation -> low hepcidin +_ DMTI -> accumulation of iron stores with _ cirrhosis and _(diabetes and skin pigmentation)

A

Hemachromatosis due to HFE protein inactivating mutation -> low hepcidin + inc DMTI -> accumulation of iron stores with micronodular cirrhosis and bronzed diabetes(diabetes and skin pigmentation)

148
Q

ristocetin cofactor assay:abnl in _

A

ristocetin cofactor assay: activates platelet gpIb to bind to vWF
abnl in vWF deficiency

149
Q

thx A2 for Gp _

A

thx A2 for Gp IIb/IIa( normal->clot)

150
Q

Sideroblastic anemia: basophillic stipping in _

Lead toxicity presents with _(colored) gumline + / drop

A

Sideroblastic anemia: ring/basophillic stipping in BM/periphery. Lead toxicity presents with bluish gumline + wrist/foot drop

151
Q

Howell jolly bodies inc if compromised _function

A

Howell jolly bodies inc if compromised splenic function

152
Q

6-MP is a cytotoxic purine analoge activated/degraded by /

A

6-MP is a cytotoxic purine analoge activated/degraded by HGPRT/XO

153
Q

/ deficiency = pernicious anemia, gastrectomy, medication, fish tapworm, diet if years/ _(drink) early onset than vegan :

hallmark for megaloblastic anemia is _neutrophils

A

Vit B12/Folate = pernicious anemia, gastrectomy, medication, fish tapworm, diet if years/ alcohol early onset than vegan : hallmark for megaloblastic anemia is hypersegmental neutrophils

154
Q 
JAK2/stat (_receptor TK) used by PIGGLET
Intracellular receptors: PET CAT TV 
cAMP: FLAT ChAMP
EDRF=NO
IP3 = GoAT HAG
TK= insulin and growth factors
A

EPO is via Jak2(activated in polycethemia vera) /stat pathway! Jak2 autophosphorylates to call stat which translocates to nucleous

Ic receptors steriods, t3-t4, vit D
cAMP: all related to acth

155
Q

peritubular_ in Kidney sense hypoxia to make EPO

A

peritubular fibroblast in Kidney sense hypoxia to make EPO

156
Q

To treat renopathy normocytic anemia give_

A

To treat renopathy normocytic anemia give EPO

157
Q

Most orophrangeal cancer looking like sheets of highly proliferative _ -positve cell are caused by _

A

Most orophrangeal cancer looking like sheets of highly proliferative cytokeratin -positve cell are caused by HPV

158
Q

Cloramphenicol causes dose in/dependent =

A

Cloramphenicol causes dose in/dependent = aplastic anemia/ thrombocytopenia

159
Q

Plummer Vinson syndrom: (4) treat with _

A

Plummer Vinson syndrom: eso webs(->disphagia), beefy tongue, spoon-shaped nails + iron deficiency anemia tret with iron

160
Q

Sickle cell also have _ deficiency due to killing of erythrocytes and after autosplenectormy (repeated splenic infacts->atophy & fibrosis) -> predispose to _ organisms.

A

Sickle cell also have folic acid deficiency due to killing of erythrocytes and after autosplenectormy (repeated splenic infacts->atophy & fibrosis) -> predispose to encapsulated organisms.

161
Q

Protamine/FFP or vitK for / reversal

A

Protamine/FFP & vitK for heparin/warfin reversal

162
Q

Aplastc(parvovirus and others cause) anemia BM ? presents with no splenomegaly
APL presents with DIC
MDS(megaloblasts) occurs in old persons
leukemias will be hypercellular

A

Aplastc anemia BM is hypocellar with fat cells

163
Q

Burik8/follicular lymphoma is / overexpression

A

Burik8/follicular lymphoma is c-myc/ bcl ;overexpression

164
Q

EBV is all primary _ lymphoma + most systemic _-cell lymphoma. On biopsy shows Ki-67 fraction (aka mitotic index) _

A

EBV is all primary CNS lymphoma + most systemic B-cell lymphoma. On biopsy shows Ki-67 fraction (aka mitotic index) high

165
Q

_ number one source of infect in sickle cell anemia due to functional asplenia so problem with encapsulated bacterias.

A

Strep pnuemo( not psuedomonas) number one source of infect in sickle cell anemia due to functional asplenia so problem with encapsulated bacterias.

166
Q

Butons( _-linked _cell diffeciency) so lack of _centers

outer cortex is for i_

A

Butons( x-linked B-cell diffeciency) so lack of geminal centers ….outer cortex is for interaction

167
Q

non/ionizing radiation = 1/2

A

non/ionizing radiation = pyrimidine dimers/ Dna ds breaks + free radicals

168
Q

Imagine CO dissociation curve. Carboxyhemoglobin only changes(2): O2 content(down) + left shift(mean high O2 affinity like myoglobin)

A

Imagine CO dissociation curve. Carboxyhemoglobin only changes(2): O2 content(down) + left shift(mean high O2 affinity like myoglobin)

169
Q

early/late porphyria = abdominal & neuro + _ urine + no/photosensitivity(manifests as_ on _ exposed areas)
Treat with ?

A

early/late porphyria = abdominal & neuro + wine-colored urine + no/photosensitivity(manifests as blisters, redness, itch on sun exposed areas) Treat with ? glucose or hemin which inhib AlAS synthase

170
Q

HA/HS/HC on electrophoresis?

A

HA/HS/HC on electrophoresis furthest/further/not further down

171
Q

Pentose phosphate pathway: non/reversible =

A

Pentose phosphate pathway: non/reversible = G6PD/transketolase= NADPH/ glycolytic(ribose) + nucleotide(frutose) intermidiate.

172
Q

cyp450 inducer(_, barbs, antiepileptics) activate alas (while _inhib alad & ferrochelase) so can trigger acute porphyria.

A

cyp450 inducer(alcohol, barbs, antiepileptics) activate alas (while lead inhib alad & ferrochelase) so can trigger acute porphyria.

173
Q

2,3 bPG cause ox affinity(dissociates easily so move to r) so if can’t bind higher O2 affinity-> example ?

H/barts=b/y tetramer

A

2,3 bPG cause dec ox affinity(dissociates easily so move to right) so if can’t bind higher O2 affinity-> example HF does not bind 2,3 bisBPG that is why bind O2 with higher affinity.. H/barts=b/y tetramer

174
Q

Treatment for gerd? 3
weak alkali minerals salts[aloh/ mg which cause / so combined to offset effect] or

PPI-prazole[ irrv bind HT-atpase can cause _ infections and _ deficiencies

cimetidine

A

Treatment for gerd? weak alkali minerals salts[aloh/ mg which cause constipation/diarrhea so combined to offset effect] or PPI-prazole[ irrv bind HT-atpase can cause c.diff infections and nutrional deficiencies

175
Q

Dopamin inhibits GI mobility that why antagonish(_) used to treat gastroparesis

A

Dopamin inhibits GI mobility that why antagonisht(metoclopramide) used to treat gastroparesis

176
Q

True diverticular(2)?

A

True diverticular(2)? merkle and appendicities

177
Q

PBC/PSC/Billiary atresia = / both/_ hepatic bile ducts = // _ age = pruitus, macrophages with _ / _ , onion skin with inc alkaline phosphotase/ intrahepatic duct prolif->_

A

PBC/PSC/Billiary atresia = intra_/ both_/extra_ hepatic bile ducts = woam_/_male/ _kid age = pruitus, macrophages with AMA / _ colitis, onion skin with inc alkaline phosphotase/ intrahepatic duct prolif->fibrosis

178
Q

Hereditary _: SPINK1 mutatation ->trypsin too active [ typsin can activate(enteropep too) &; inhib self]

A

Hereditary pancretitis: SPINK1 mutatation ->trypsin too active [ typsin can activate(enteropep too) & inhib self]

179
Q

Chrons disease can have _stones too because mostly affects _ where bile is absorbed.

A

Chrons disease can have gall_stones too because mostly affects illeum_ where bile is absorbed.

180
Q

H. pyloric( acute/chronic= prox_/_ where)

Zollinger-ellison gastrinoma(duodenom, or _) with ulcers
_ duodenal bulb and _gastrin response to secretin.

A

H. pyloric( acute/chronic= prox_/_ where)/ Zollinger-ellison gastrinoma(duodenom, or _) with ulcers beyond duodenal bulb and _gastrin response to secretin.

181
Q

Autoimmune gastritis is _inflammation @ fundus/body with

_ cell destruction

A

Autoimmune gastritis is CD4 inflammation @ fundus/body with parietal cell destruction

182
Q

Autoimmune _= anti sm

A

Autoimmune hepatitis = anti sm

183
Q

inhaled_ anesthetics cause _ hepatitis with marked elevation in _ + prolong PTT(albumin _ because long half life)

A

inhaled_ anesthetics cause fulmigant hepatitis with marked elevation in ALT + prolong PTT( alb normal because long half life)

184
Q

Shigella targets _-cells

A

Shigella targets _-cells

185
Q

gall stone illues: pneumobilia/pneumatosis = air in /? due to cholescytoenteric fistula/ perforation

A

gall stone illues: pneumobilia/pneumatosis = air in /? due to cholescytoenteric fistula/ perforation

186
Q

C. difficle considered _ diarrhea

A

C. difficle considered inflammatory diarrhea

187
Q

_ intestinalis(_ in bowel _) confirms necrotizing enterocolitis in _ newborns who have _ feeding.

A

pneumatosis intestinalis(_ in bowel _) confirms ecrotizing enterocolitis in premature newborns who have formula feeding.

188
Q

Neoplastic(2) polyps /non(4)= , adenomatous(>tubular)/ hyperplastic, juvenile(_omas), inflammatory( like crohns), submucosal(lipomas or ) ; most important malig factor is inc poly

A

Neoplastic(2) polyps /non(4)= serrated, adenomatous(_>tubular)/ hyperplastic, juvenile(_omas), inflammatory( like crohns), submucosal(lipomas or _) ; most important malig factor is inc poly size

189
Q

_ disease: systemic so presents with malabsorption _, joint & CNS problems. by tropheryma whippelii forms _ macrophages with _ bacteria + _stain + diastase resistant granules.
Seen in Pop?

A

Whipple disease: systemic so presents with malabsorption diarrhea, joint & CNS problems. by tropheryma whippelii forms _ macrophages with bacilli bacteria + _stain + diastase resistant granules. Seen in middle-age white males

190
Q

Pancreatic cancer: _ is major ENV. risk factor( PJS + HNP colon cancer as well)

A

Pancreatic cancer: smoking is major env. risk factor( PJS + HNP colon cancer as well)

191
Q

process meat & low fiber risk factor for _cancer

A

process meat & low fiber risk factor for colon cancer

192
Q

Antitrpys deficiency present also with_ disease due to accumulation

A

Antitrpys deficiency present also with liver disease due to accumulation.

193
Q

hemachromatosis/ wilson diseas = iron/copper acccum = deposits in joint, pancreas(bronzed diabees), heart/ phychiatiric & neuro problems.

A

hemachromatosis/ wilson diseas = iron/copper acccum = deposits in joint, pancreas(bronzed diabees), heart/ phychiatiric & neuro problems.

194
Q

Vit a deficiency presents?

A favors _

A

Vit a deficiency presents blindness + dryness(eye + skin due to no keratonocyte diff) + itchy( due to hyperkeratosis) so vit A favors diff over prolif.

195
Q

Rifaximin/lactulos both for hepatic encephalopaty mech?

A

Rifaximin/lactulos both for hepatic encephalopaty by dec production/ in conversion to ionic form

196
Q

curling/crushing ulcers from ?

A

curling/crushing ulcers from trauma like burn/ intracranial injury -> dec mucosal protect/ in vagal->acid

197
Q

APC/ (Kras,dcc), p53/ msh,mlh1 = earlier/later mutations in / dna repair = all FAP + most sporatic/ (either) colon carcinoma only/ lynch syndrom HNNPC

A

APC/ (Kras,dcc), p53/ msh,mlh1 = earlier/later mutations in / dna repair = all FAP + most sporatic/ (either) colon carcinoma only/ lynch syndrom HNPC

198
Q

nonspecific Viral hepatitis presents with _ inflitration with hepatocyte necrosis( appear _ with _ cytoplasm) forming councilman bodies (_ _cells).

A

Viral hepatitis presents with lymphocytic inflitration with hepatocyte necrosis( appear balloned_ with pale cytoplasm) forming councilman bodies (eosionophilic apoptotic cells).

199
Q

specific Acute/ chronic viral hepatitis = / _ inflammation with pale eosinophilic ground glass hepatocytes(hep) or fat(Hep _)

mallory bodies(eosinophilc intermediate filaments)

A

Acute/ chronic viral hepatitis = panlobulor/ portal triad inflammation with ground glass hepatocytes(hepB) or fat(Hep C)

200
Q

right/left colon cancer present like?

A

right/left colon cancer = large/small = occult bleed-iron def anemia/obstruct

201
Q

Asprin used may be preventative of _ adenocarcinomas because Cox-_ block prevents cancer growth(specific for colon adenocarcinoma)

A

Asprin used may be preventative of colon adenocarcinomas because Cox-2 block prevents cancer growth(specific for colon adenocarcinoma)

202
Q

autoimmune gastritis/ h.pylori (acute/chronic at antrum/body) assoc with adenocarinoma + _/malt lymphoma.

A

autoimmune gastritis/ h.pylori (acute/chronic at antrum/body) assoc with adenocarinoma + carcinoid/malt lymphoma.

203
Q

In appendicitis surgery, _is landmark

A

In appendicitis surgery, tenia coli is landmark not psoas muscle( only for examinations not even diagnosis cause not specific)

204
Q

Lymph node drainage of ant rec(IM)/mid rec (_ + I_)/anus(inguinal) follows arteries

middle colic is anastamosis?
rectum drianage before/after dentate line = ?

A

Lymph node drainage of ant rec(IM)/mid rec (IM + Illiac)/anus(inguinal) follows arteries
middle colic is anastamosis of IMA & SMA
rectum drianage before/after dentate line = IM & illac/ inguinal = sup & mid/ lower rectum

205
Q

Cryptosporidium stains _shows _organisms; limited/advanced watery diarrhea in /. histology of intestine shows?

A

Cryptosporidium stains acid fast shows cystic organisms; limited/advanced watery diarrhea in not/compromised. histology of intestine shows inflam infiltrate in lamina propira( with blunt vili) and basophilc cyst lining epithelium

206
Q

Pacreatic ventral/dorsal bud?

A

Pacreatic ventral/dorsal bud= head(uncinate process?) /body + sup part of head = main(Wirsung) / accessary duct if unfused (if fused main in within body)

207
Q

Pancreatic divisum(unfused) can present with _

A

Pancreatic divisum(unfused) can present with recurrent pancretitis.

208
Q

retroperitoneal bleeds mnuemonic :SA_( exept 1st part!)PUCKE_(mid-distal)…aorta vrs pancreatic bleed hi/lo shock(bp)

A

retroperitoneal bleeds mnuemonic :SAD( exept 1st part!)PUCKER(mid-distal)…aorta vrs pancreatic bleed hi/lo shock(bp)

209
Q

sliding/paraesophageal hernias of GE ?

A

sliding/paraesophageal hernias of GE juction/ fundus (parts of stomach) due to para esophagea membrane laxity/ hole ( + laxity( of gastrocolic & splenic ligaments too)

210
Q

Bochdaleck/lesser sac hernia =

A

Bochdaleck/lesser sac hernia =t hrough post diaphragm/ through foramen of winslow?

211
Q

urethra,lower vagina, eustacian tube and PC cells are ?

laryngeal cartilage and teeth?

A

Embroyonic parts? Pf cells now endoderm

, Gi, lungs, thyroid, parathyroid, eustachian tube, urethra

212
Q

HCV gene unstable because 2?

A

HCV gene unstable because no proofreading due to no 3-5 exonuclease enz + hypervariable region in envelop glycoprotein.

213
Q

Dna primase/glycosylase does? = Rna primer/ BP repair removes NG base

A

Dna primase/glycosylase does? = Rna primer/ BP repair removes NG base

214
Q
  1. D-Galactosemia: GALT: galac1p->glu1 so deficiency -> juandice due to (galac1p accum), _ sepsis, to treat, change diet to _ milk( s for sucrose)

Phosphoglucomutase: glu1p ->glu6p

GALK: galac->galac1p so indeficiency benign _ due to galactitol accum

Aldose _: galac->galactitol (also glu->sorbitol)

A
  1. D-Galactosemia: GALT: galac1p->glu1 so deficiency -> juandice due to (galac1p accum), E.coli sepsis, to treat, change diet to Soy milk( s for sucrose)
    Phosphoglucomutase: glu1p ->glu6p
    GALK: galac->galac1p so indeficiency benign cataracts due to galactitol accum
    Aldose reductase: galac->galactitol (also glu->sorbitol)
215
Q

tetrodotoxin in pufferfish block V.gated _

A

tetrodotoxin in pufferfish block V.gated Na

216
Q

verapamil blocks _-type Ca

A

verapamil blocks L-type Ca

217
Q

Erythrocytosis criteria? What distinguishes absolute(hyposia induced how measure, BM, EPO) from relative.? Relative due to volume _?

A

Erythrocytosis criteria? What distinguishes absolute(hyposia induced how measure, BM, EPO) from relative.? Relative due to volume _?
Hematocrit >50+-2 for men and women. Rbc mass distinguish absolute from relative. Measure hypoxia induced with SaO2 <92% or paO2 <65; volume contraction

218
Q

HIV/AIDs with colitis: consider _(looks like?)

A

HIV/AIDs with colitis: consider _(looks like?)

CMV: cells with basophilic intranuclear inclusions

219
Q

What does microsporidium(like _) cause?

A

What does microsporidium(like cryptosporidium) cause?

Diarrhea with destruction of villus architecture

220
Q

Hairy cell leukemia presents in Pop? Hallmark(2)

A

Hairy cell leukemia presents in Pop? Hallmark(2)

Middle-aged men; bone marrow failure(dry tap, pancytopenia) & splenomegaly

221
Q

_ sideroblasts are found in myelodysplastic syndrome

A

Ringed sideroblasts are found in myelodysplastic syndrome

222
Q

Host protease cleaves what protein in HIV?

A

Host protease cleaves what protein in HIV?

Viral/host protease cleave gag-pol/env polyprotiens-> protease inhibs blaock viral protease-> immature virons

223
Q

Ig A is not in _ not serum.

A

Ig A is not in _ not serum.

224
Q

Neonatal tetanus prevented via? Immunization whom?

when can immunize kid?

A

Neonatal tetanus prevented via? Immunization whom?

Cord care? Immunize mother with IgG then active immunization (around 2 mths not at birth!)

225
Q

Myeloproliferative disorders present? Gain of function mutation of ? A what type of receptor?

A

Myeloproliferative disorders present? Gain of function mutation of ? A what type of receptor?
Labs with elevated myloid cells. have JAK2( non receptor cytoplasmic TK) gain mutation

226
Q

Poisoning:
_ Na channels(2)
Puffer fish = _otoxin
(dinoflagellates in red tide =Saxitoxin )

_ NA open (2)
eel/ frogs = ciguatoxin/batachotoxin

A

Poisoning:
Puffer fish/ dinoflagellates in red tide = tetradotoxin/Saxitoxin = inihb NA channels
eel/ frogs = ciguatoxin/batachotoxin = keep NA open

227
Q

Cifovir and foscarnet do _ require viral kinase

A

Cifovir and foscarnet do not

228
Q

On histology: infectious mono(what organ problem is very indicative) vrs neutrophil? Other cells look like: monocyte, eosioinphil, basophil, lymopho, plasma?

A 
On histology: infectious mono(what organ problem is very indicative) vrs neutrophil? Other cells look like: monocyte, eosioinphil, basophil, lymopho, plasma?
Atypical lymphocyte(splenomegaly) with abundant cytoplasm vrs hypersegmented granule.  Notch, bilobed with major basic protein, obscured nuclei, small cytoplasm, spoke-wheel chromati + perinuclear paleness
229
Q

Meconium ileus due to ? specific for what disease

A

Meconium ileus due to ? specific for what disease

Inspissated (dehydrated) meconium ; CFTR( die from pneumonia, bronchiectasis, cor pulmonale)

230
Q

Air-fluid levels with bowel dilation on X ray means?

A

Air-fluid levels with bowel dilation on X ray means?

Bowel obstruction

231
Q

HIV with ocular disease? On funduscopy? Treat?

A

HIV with ocular disease? On funduscopy? Treat?

CMV retinitis: yellow white, fluffly retinal lesions around vessels with hemorrhage; Gangcycovir

232
Q

Colon adenoma -> carcinoma sequence ?

A

Colon adenoma -> carcinoma sequence ?

APC tsg mutation->kras mutation for proliferation-> p53 mutation so apc / p53 in most adenoma/carcinoma

233
Q

Bilary sludge (especially _ stone which is different from brown pigment stone( due to biliary tract_)

A

Bilary sludge (especially cholesterol which is different from brown pigment stone( due to biliary tract infection))

234
Q

IgA protease producers?(4) How does IgA protect?

A

IgA protease producers?(4) How does IgA protect?

N.gono & meningis, s.pnue, h.infl, ; IgA is a mucosal immunoglobin protects by preventing mucosal adherence.

235
Q

Pneumocystis pneumonia common in what pop? What stain? Treat?

A

Pneumocystis pneumonia common in what pop? What stain? Treat?
Advanced HIV, special stains(silver), TM-SMX

236
Q

Ceftriaxone and azithromycin can treat _ pneumonia?

A

Ceftriaxone and azithromycin can treat _ pneumonia?

Community acquired.

237
Q

Incontinences types? Disease assoc?
Posterior vaginal wall prolapse: aka
Rectocele?

A

Incontinences types? Disease assoc?
Posterior vaginal wall prolapse: aka
Rectocele?

238
Q

Rabies presents? post-exposure propylaxic?
_-like prodome with spasms and _ flaccid paralysis ;
Ig and inactivated vaccine( _effective after symptom onset.

A

Rabies presents? Post-exposure propylaxic
Flu-like prodome with spasms and acending flaccid paralysis ; Ig and inactivated vaccine( not effective after symptom onset.

239
Q

CYP450 inducer/inhibitors? How affect drug metabolism & serum concentration

Drugs metabolized by cYP450? 3

A

barbs, rifampin, griseofulvin, chronic alcohol/ ritonavir, isoniazid, cimetidine, macrolides, azoles, grapefruit= Inc/dec drug metabolism->dec/inc serum concentrations of drug.

statins, phenytoin, warfirn, cyclophosphamide

240
Q

Intestinal vrs diffuse gastric adenocarcinoma ? Signet ring cell look on histology?

A

puched out ulcer with raised margins/Solid luminal mass of cuboidal/columnar cells vrs linistis plastica with mucin producing signet ring cells

241
Q

Islands or sheet of uniform cells with eosinophilic cytoplasm and oval to round stippled nuclei ?

A

Carcinoid tumours on histology?

Islands or sheet of uniform cells with eosinophilic cytoplasm and oval to round stippled nuclei

242
Q

Which malaria protozoa does not have dormant liver phase? How does mefloquine work? How long must take it for?

A

Which malaria protozoa does not have dormant liver phase? How does mefloquine work? How long must take it for? Falciparum( no hypnozoite( are sleeping in liver) but has schizont which are active in rbc); mefloquine kills schizonts; 4 wks after return due to schizonts release from liver

243
Q

CLL vrs Hodgkin lymhoma?

A

CLL vrs Hodgkin lymhoma? Both B cell( 3 markers after cd19) but Hodgins Is localized and cll is leukemia.

244
Q

If see esophageal biopsy look for ss, reflux esophagitis, barets, leiomyoa ?

A

If see esophageal biopsy look for ss, relux esophagitis, barets, eiomyoa = keratin pearls, esoinophiles, goblet cells, spindle cells.

245
Q

Most common presentation of cryptococcus neoformis?

A

Most common presentation of cryptococcus neoformis?

Meningoencephalitis

246
Q

Which expression in breast cancer suggest more aggressiveness

A

Which expression in breast cancer suggest more aggressiveness
HER2 ( bcl is good prognosis unlike in lymphoma)

247
Q

Criptoneoformis hallmark? Color on mucicamine stain, most common disease?

A

Criptoneoformis hallmark? Color on mucicamine stain, most common disease?
polysaccharide capsule that is red on mucicamine stain affects pop( immuncocompromised)

248
Q

Causes of Candida overgrowth in vagina(1 most common, other not)? ph?

A

Causes of Candida overgrowth in vagina(3)? Most common?
estrogen( steroids, preg), diabetes, immunosupression(antibiotic most common: pathophysio is because reduces lactobacilli) unlike Trichomonas & vaginosis ph is typically low

249
Q

Naegleria fowleri?

Motile trophozoite

A

Naegleria fowleri?

Is a motile trophozoite causes meningoencephalitis gotten from water activities

250
Q

Erythema multiform looks like? Gotten from(2) pathogeniesis and type of immune response?

A

Erythema multiform looks like? Gotten from(2) pathogeniesis and type of immune response?
target shaped lesions from HSV or mycoplasma pneumoniae leads to deposition of antigens in keratinocytes hence cytotoxic-Tcell response.

251
Q

Treat criptoneoformis?

A

Treat criptoneoformis?

Ampho + flucytosine then varconisol( playing flute to call amphebians)

252
Q

_precursor of bilary stone(especially cholesterol) formations?

A

billary sludge precursor of bilary stone(especially cholesterol) formations?

253
Q

Chron’s disease fistulas can form with _:

A

Chron’s disease fistulas can form with _: Enterocutaneous fistulas

254
Q

Vinca alkaloids work @? Side effects?

A

Vinca alkaloids work @? Side effects? Mitosis phase of cell cycle; peripheral neuropathy &neurotoxicity

255
Q

Colitis vrs sporadic associated colorectal cancer

A

Colitis vrs sporadic associated colorectal cancer

Colitis is younger, flat, proximal, multi-focal and more aggressive because adenoma to carcinoma sequence flipped.

256
Q

Staph food poisoning is _ heat-stable enterotoxin because _onset.

A

Staph food poisoning is preformed heat-stable enterotoxin because rapid onset.

257
Q

Gi tract iron deficiency anemia is due to_ blood .

A

Gi tract iron deficiency anemia is due to occult blood so can’t rule out lack of dark or bright red stool in patient.

258
Q

Chemo induced neutropenia(fevers) due to _bacteria release from chemo _ site damage

A

Chemo induced neutropenia(fevers) due to endogenous bacteria release from chemo musocal site damage

259
Q

Immunity against Gardia lambia trophozite is _

A

Immunity against Gardia lambia trophozite is IgA not via neutrophil!

260
Q

How is INH metabolized?

A

How is INH metabolized? by acetylation ( can be fast or slow with slow one having more drug side effects)

261
Q

How can proteasome inhibitors(bortezomib: boronic acid) treat MM?

A

How can proteasome inhibitors(bortezomib: boronic acid) treat MM? Hi Ig synthesis so if inhib proteasome -> proapopototic protein accumulate -> cell apoptosis

262
Q

Diet Risk factors for diverticulosis(4)? Looks like on resected colon?

A

Diet Risk factors for diverticulosis? Looks like on resected colon? Red meat(obese), low fiber, inactivity, smoke. Outpouching (vrs polyps) with fecal matter.

263
Q

Bordetella pertussis and h.influ are both shape? Bordetella presents?

A

Bordetella pertussis and h.influ are both shape? Bordetella presents? Bordetella toxins 2 g- coccobacillus; with dry cough with vomiting; tracheal/pertussis= destroy ciliated cells/inc CAMP ->cough/lymphocytosis

264
Q

Elisa tests for HIV is for _ antiboides
elisa measures virus _
western blot to _

A

Elisa tests for HIV is for non-specific antiboides
elisa measures virus antibody titers
western blot to confirm

265
Q

Nocardia is _ and causes pneumonia & brian _ ( as opposed to actinomyces israli)

A

Nocardia is partially acid-fast and causes pneumonia & brian abscesses ( as opposed to actinomyces israli)

266
Q

HTLV cause leukemia in southern _

A

lol

267
Q

leukocytoclastic vasculities is due to _or _-> nonblanching purpura without significan bleeds.

Chrons consider effects of (3)

autoimmune hepatitis: pop? association?

A

leukocytoclastic vasculities is due to antibiotic or viral hepatitis-> nonblanching purpura without significan bleeds.

Chrons consider effects of ADEK, gallstones, diarrhea

autoimmune hepatitis: women, ulcerative colities

268
Q

hepatic encephalopahty is precipitated by _( that inc ammonia levels)

A

hepatic encephalopahty is precipitated by stressure( that inc ammonia levels)

Asem (9 decks)

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