MSK

Question 1

Antifolate antiproliferative

Answer 1

Methotrexate

MoA:
Inhibition of dihydrofolate reductase and DNA syntesis for lymphocyte proliferation

Indications:
RA

Side Effects:
Nausea, hair loss

Interactions:
Warfarin, corticosteroids

Question 2

Antimetabolite immunosuppressant

Answer 2

Azathioprine

MoA:
Unclear - possinle inhibition of DNA synthesis and lymphocyte proliferation

Indications:
RA (also Crohn’s Disease)

Side Effects:
Alopecia

Question 3

Cytokine modulators

Answer 3

Adalimumab, Etanercept, Infliximab

MoA:
TNF-alpha blockade

Indications:
RA

Side Effect:
Infections

Question 4

Aminosalicylates

Answer 4

Sulfasalazine, Mesalazine

MoA:
Unclear - possible COX inhibition. Possible free radical scavenging, T cell suppression.

Indications:
RA (also Crohn’s Disease)

Side Effect:
Nausea

Interactions:
Digoxin, Warfarin