Anti-neoplastic Flashcards
Classical alkylating agents
Cyclophsosphamide
MOA:
DNA crosslinking
Indications:
Malignancies
Side Effects:
Hair loss, bone marrow suppression, nausea
Taxanes
Paclitaxel, Docetaxel
MOA:
Inhibition of microtubule assembly in mitotic spindle
Indications:
Malignancies
Side Effects:
Hair loss, bone marrow suppression, nausea
Vinca Alkaloids
Vincristine, Vinblastine
MOA:
Inhibition of microtubule assembly in mitotic spindle
Indications:
Malignancies
Side Effects:
Hair loss, bone marrow suppression, nausea
Antifolates
Methotrexate
MOA:
Inhibition of dihydrofolate reductase and DNA Synthesis
Antipyrimidines
Fluorouracil, Cytarabine
MOA:
Inhibition of RNA and DNA synthesis
Indications:
Malignancies
Side Effects:
Hair loss, bone marrow suppression, nausea
Antipurines
Mercaptopurine, Thioguanine
MOA:
Inhibition of RNA and DNA synthesis
Indications:
Malignancies
Side Effects:
Hair loss, bone marrow suppression, nausea
Anthracycline Abx
Doxorubicin
MOA:
DNA intercalation; inhibition of RNA and DNA synthesis
Indications:
Malignancies
Side Effects:
Hair loss, bone marrow suppression, nausea
Antineoplastic monoclonal Abs
Trastuzumab
MOA:
Targeting of cells overexpressing HER2 for tumor reduction & destruction
Indications:
Early Breast CA
Rituximab
MOA:
Targeted destruction of CD20+ B cells
Indications:
Follicular lymphoma, Non-hodgkin’s
Nivolumab
MOA:
Stimulation of anti-tumour responses via blocking PD-1
Indications:
Melanoma
Side Effects:
All Fever and chills
Immunomodulator
Lenolidamide
MOA:
Stimulation of T cell responses
Indication:
Myeloma
Side Effects:
Foetal risk
Selective estrogen recpetor modulator (SERM)
Tamoxifen
MOA:
Inhibition of oestrogen receptor function and cell proliferation in breast
Indication:
Breast CA
Luteinising hormone releasing hormone (LHRH) receptor agonist
Goserelin
MOA:
Synthetic analogue of LHRH. Activates LHRH receptor function leading to susatined reduction in testosterone
Indication:
Prostate CA
