CNS

Question 1

Reverse inhibitor of Monoamine Oxidase type A (RIMA)

Answer 1

Moclobemide

MoA:
Inhibits monoamine oxidase A, preferentially decreases breakdown of sertonin and NorA.

Indication:
Depression

Side Effects:
Tachycardia

Question 2

TCAs

Answer 2

Amitriptyline, Nortriptyline, Dosulepin

MoA:
Inhibition of NorA and serotonin reuptake in synaptic cleft, H1 anatgonist, M1 anatgonist, adrenergic antagonist

Indication:
Depression

Side Effects:
Anticholinergic syndrome

Question 3

Antipsychotics - Classical (1st Gen)

Answer 3

Chlorpromazine, Haloperidol

MoA:
Selective D2 dopamine and 5-HT receptor blockade

Indication:
Schizophrenia

Side Effects:
Blurred vision, tremor, EPS, hypotension

Question 4

Antipsychotics - Atypical (2nd Gen)

Answer 4

Olanzapine, Risperidone, Quetiapine, Clozapine, Amisulpride

MoA:
Selective D2 dopamine and 5-HT receptor blockade

Indication:
Schizophrenia

Side Effects:
EPS (less than classical), hypotension

Question 5

Non-benzodiazepine Hypnotic

Answer 5

Zopiclone

MoA:
GABA PAM (y-subunit) Enhanced effects of GABA

Indication:
Insomnia

Question 6

H1-receptor antagonist (Anti-emetics)

Answer 6

Cyclizine

MoA:
Histamine H1 receptor blockade

Indication:
Nausea, vomiting

Side Effects:
Dry mouth, Sedation

Interactions:
Sedatives

Question 7

D2-receptor antagonist (Anti-emetics)

Answer 7

Domperidone

MoA:
D2 receptor blockade in the chemoreceptor trigger zone

Indications:
Nausea, Vomiting

Side Effects:
Cardiac Disease