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Phase II Drugs List > Infections > Flashcards

Infections Flashcards

1
Q

Penicillins (beta lactam) - (Antibiotics)

A

Amoxicillin, co-amoxiclav, Piperacillin-Tazobactam (Tazocin), Flucloxacillin, phenoxymethylpenicillin, benzylpenicillin

MoA:
Beta-lactam - inhibition of bacterial cell wall synthesis

Indications:
Respitatory infection, pneumonia, H pylori.

Side Effects:
Rash, Hypersensitivity

Interactions:
Warfarin, methotrexate

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2
Q

Carbapenems (beta lactam )- (Antibiotics)

A

Meropenem

MoA:
Beta-lactam - inhibition of bacterial cell wall synthesis

Indications:
Meningitis, hospital-acquired septicaemia

Side Effects:
Abdo Pain, pruritis

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3
Q

Cephalosporins (beta lactam) - (Antibiotics)

A

Ceftriaxone

MoA:
Beta-lactam - inhibition of bacterial cell wall synthesis

Indications:
Gram-negative infections, meningitis

Side Effects:
GI disturbances, colitis

Interactions:
Warfarin

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4
Q

Antifolate antibiotic

A

Trimethoprim

MoA:
Inhibition of dihydrofolate reductase

Indications:
UTI

Side Effects:
Rash, GI disturbances

Interactions:
Methotrexate

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5
Q

Fluoroquinolones - (Antibiotics)

A

Ciprofloxacin

MoA:
Inhibition of bacterial DNA gryase

Indications:
Respiratory tract infection

Side Effects:
Nausea, convulsions

Interactions:
Iron salts, NSAIDs

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6
Q

Macrolide antibiotic

A

Erythromycin, Azithromycin

MoA:
Inhibition of bacterial protein synthesis

Indications:
Pneumonia

Side Effects:
Gi Disturbances, headache

Interactions:
Digoxin, theophylline, statins

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7
Q

Tetracycline Antibiotic

A

Doxycycline, Tetracycline

MoA:
Inhibition of bacterial protein synthesis

Indications:
CAP

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8
Q

Nitrofuran - (Antibiotics)

A

Nitrofurantoin

MoA:
Bacterial DNA interference

Indications:
UTI

Side Effects:
Peripheral neuropathy

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9
Q

Aminoglycoside - (Antibiotics)

A

Gentamicin

MoA:
Inhibition of bacterial protein synthesis

Indications:
Ophthalmic infection

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10
Q

Glycopeptide - (Antibiotics)

A

Vancomycin

MoA:
Inhibition of cell wall synthesis in Gram-positive bacteria

Indications:
C. difficile

Side Effects:
Neutropenia, renal impairment

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11
Q

Nitroimidazole (anti-anaerobe) - (Antibiotics)

A

Metronidazole

MoA:
Inhibition of bacterial DNA synthesis

Indication:
Anaerobic bacterial infection - leg ulcers, pressure sores

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12
Q

Antituberculosis drugs - (Antibiotics)

A

Isoniazid, Ethambutol, Rifampicin, Pyrazinamide

MoA:
Inhibition of mycobacterial cell wall synthesis (Isoniazid, Ethambutol)
Inhibition of mycobacterial RNA synthesis (Rifampicin)

Indication:
TB

Side Effects:
Hepatotoxicity

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13
Q

Therapeutic cytokines

A

INF-alpha

MoA:
Activation of antiviral intracellular and immune responses

Indications:
Hep B and C

Side Effects:
Flu-like symtoms, loss of appetite

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14
Q

DNA polymerase inhibitors

A

Aciclovir, Ganciclovir

MoA:
Virus replication blockade

Indication:
Herpes simplex

Side Effects:
Nausea, diarrhoea

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15
Q

Neuraminidase inhibitiors

A

Osteltamivir

MoA:
Prevention of viral budding and infectivity

Indication:
Influenza virua

Side Effects:
Nausea and Vomiting

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16
Q

Nucleoside analogues

A

Ribavirin

MoA:
Disrupts viral RNA synthesis

Indications:
Hep C and RSV

17
Q

Nucleoside reverse transcriptase inhibitors (NRTI)

Non-nucleoside reverse transcriptase inhibitors (NNRTI)

A

Tenofovir
Efavirenz

MoA:
Blockade of viral reverse transcriptase function for viral genetic replication

Indication:
HIV

Side Effects:
Rash, Stevens-Johnson syndrome

18
Q

Viral protease inhibitors

A

Lopinavir

MoA:
Blockade of viral protease required for virus particle assembly

Indication:
HIV

Side Effects:
GI bleeding

19
Q

Integrase Inhibitors

A

Dolutegravir

MoA:
Disrupts integration of HIV genome into host chromosomes

Indication:
HIV

20
Q

Viral fusion inhibitors

A

Enfuvirtide

MoA:
Blockade of virus fusion to target cell membrane

Indication:
HIV

Side Effects:
Pancreatitis

21
Q

Chemokine receptor/CCR5 antagonist

A

Maraviroc

MoA:
Blockade of HIV binding to co-factor for cell entry

Indication:
HIV

Side Effects:
Nausea, diarrhoea

22
Q

Triazole anti-fungal agent

A

Fluconazole

MoA:
Disruption of fungal membrane function

Indication:
Candida infection

Side Effects:
Nausea, abdo pain

Phase II Drugs List (9 decks)

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