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2a RRS > MSK > Flashcards

MSK Flashcards

1
Q

what is systemic lupus erythematosus

A

Autoimmune connective tissue disorder

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2
Q

pathophysiology of SLE

A

inflam multisystem autoimmune disorder
relapsing and remmitting - scarring of tissue leading to organ failure
type III hypersensitivity disorder - antigen antibody complexes

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3
Q

what type of hypersensitivy is SLE

A

type 3 - antigen antibody complexes

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4
Q

epidem of SLE

A

young (20-40 = commonest onset) 14-64yo
F>M (9:1)
0.2% prevalence

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5
Q

clinical features of SLE in general and tissue commonly effected

A 
Fever, malaise, fatigue, arthralgia and skin probs (malar rash)
affects- 
skin 
lungs 
joints 
heart 
kidney
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6
Q

SLE, clinical features of skin

A 
Malar rash, 
photosensitive rash 
discoid rash (commonest rash) 
alopecia 
raynaud's phenomenon
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7
Q

SLE, clinical features of lungs

A

pleuritis (within serositis)

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8
Q

SLE, clinical features of joints

A

arthralgia, symmetrical, non erosive

arthritis

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9
Q

SLE, clinical features of heart

A

Pericarditis

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10
Q

SLE clincial features of the kidney

A

glomerulonephritis, can develop into haematuria and proteinuria

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11
Q

SLE Clinical features for diagnosis

A 
SOAP BRAIN MD = 4+ of...
Serositis (pleuritis, pericarditis, peritonitis)
Oral ulcers
Arthritis (2+ joints)
PHOTOSENSITIVITY
Blood disorders (low everything - haemolytic anaemia, leucopenia etc)
Renal disorders - haematuria proteinuria 
ANA POSIVE (anti nuclearantibodies)
Immunological disorder (anti-dsDNA, pos antiphosphlipid Ab)
Neurological disorder (seizures, migraines)

Malar rash
Discoid rash

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12
Q

signs of SLE

A 
pale mucous membranes
oral ulcers
murmur
malar rash 
discoid rash
ataxia
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13
Q

synmptoms of sle

A 
lethargy
joint pain
muscle pain (arthralgia)
photosensitivity 
chest pain (serositis)
SOB
gritty eyes (secondary Sjogrens syndrome, retinal vasculitis)
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14
Q

accronymn general things SLE

A 
DOPAMINE RASH
Discoid rash
Oral ulcers
Photosensitivity
Arthritis
Malar rash
Immune markers (dsDNA)
Neuro changes (seizures, physchosis)
ESR increase

Renal (proteinuria)
ANA pos
Serotosis (pericarditis pleuritis peritonitis)
Haemolytic anaemia

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15
Q

what see on bloods of SLE

A 
FBC - anaemia pancytopenia 
high ESR/CRP
ANA psotive
U&Es - high urea high creatinine
Autoantibodies - antiphospholipid antibodies, dsDNA antibody
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16
Q

things buzz word for SLE diagnosis

A 
anti dsDNA
ANA postive
Arthritis/ arthralgia 
Discoid Rash Malar rash
renal dysfunction
17
Q

Different rashes in SLE

A

Malar rash (erythema) malar means cheek, erythema means redness
Discord Rash
Photosensitive rash

18
Q

Management of SLE

A

normal management - Hydroxychloroquine (anti-Malarial) +NSAIDs. THEN use methotrexate
Flare ups- Corticosteroids injections for arthritis or prednisone + NSAIDs
conservative - biphosphonates - osteoporosis
antidepressants
EDUCATION

2a RRS (26 decks)

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