MSK Flashcards
Which is more common? Malignant primary bone tumours or metastatic cancer affecting the bone?
metastatic cancer affecting bone
What is the commonest benign bone tumour and what are its characteristics?
Osteochondroma- produces a bony outgrowth on the external surface with a cartilaginous cap
True or false: an Osteochondroma is always benign?
False- there is a small risk of malignant transformation
What causes an Enchondroma?
failure of the normal enchondral ossification at the growth plate causing a metaphyseal cartilaginous tumour.
Where do enchondromas usually occur?
Femur, humerus, tibia and small bones of the hands and feet.
What is a simple bone cyst?
a single cavity benign fluid filled cyst in a bone.
What is the difference between aneurysmal bone cysts and simple bone cysts?
Simple bone cysts are just fluid filled sacs on the bone but aneurysmal bone cysts contain chambers that are filled with blood or serum.
Where to Giant cell tumours occur?
around the knee and in the distal radius but can also occur in the long bones, pelvis and the spine.
What is the appearance of giant cell tumours on x-ray?
soap bubble appearance
If giant cell tumours were to metastasise, where are they most likely to?
lung
What is the treatment for a giant cell tumour?
intralesional excision with use of phenol, bone cement or liquid nitrogen to destroy remaining tumour material.
What is fibrous dysplasia?
disease of the bone usually occuring in adolescence where a genetic mutation results in lesions of fibrous tissue and immature bone. The affected bone is wider with thinned cortices.
When would a shepards crook deformity occur?
When there is extensive involvement with the proximal femur in fibrous dysplasia.
What is the treatment for fibrous dysplasia?
bisphosphonates may reduce pain and pathologic fractures should be stabilised with internal fixation and cortical bone graphs used to improve strength.
Are giant cell tumours benign or malignant?
benign
What is an osteoid osteoma?
a small nidus of immature bone surrounded by a sclerotic halo. They are characterised by intense constant pain worse at night due to the inflammatory response.
What is the treatment for an osteoid osteoma?
NSAIDs help with the inflammatory process. The lesion may resolve spontaneously over time but some cases need CT guided radiofrequency ablation.
What are the benign one tumours?
Osteochondroma, enchondroma, giant cell tumour, fibrous dysplasia, osteoid osteoma, simple bone cyst & aneurysmal bone cyst.
What are the cancers most likely to metastasise to bone?
Breast Bronchus (lung) prostate thyroid kidneys
What age groups are most commonly affected from metastatic bone tumours?
people under 20 and over 60.
What might be seen on x-ray in metastatic bone cancer?
cortical destruction, a periosteal reaction (raised periosteum producing bone), new bone formation and extension into the surrounding soft tissue envelope.
What is the most common form of primary bone tumour?
Osteosarcoma
Where do osteosarcomas usually present?
Around the knee, proximal femur, proximal humerus and pelvis.
What is the treatment for osteosarcomas?
they are not radiosensitive but adjuvant chemotherapy can prolong survival.
What is a chondrosarcoma?
A cartilage producing primary bone tumour and is less common and less aggressive than osteosarcoma.
Do chondrosarcomas metastasise?
yes
Where are chondrosarcomas usually found?
the pelvis or proximal femur.
What is a fibrosarcoma?
fibrous malignant primary bone tumours which tend to occur in abnormal bone e.g. fibrous dysplasia, post irradiation, Pagets disease.
What is Ewings Sarcoma?
malignant tumour of primitive cells in the marrow. it is the second most prevalent primary bone tumour.
How does Ewings Sarcoma present?
fever, raised inflammatory markers and a warm swelling- it may be misdiagnosed as osteomyelitis.
Which malignant bone tumour has the worst prognosis?
Ewings sarcoma
What is the treatment of primary bone tumours?
tends to involve surgery to remove the tumour and surrounding tissue to reduce the risk of recurrence. Adjuvant chemotherapy and radiotherapy are used if appropriate.
What is a lymphoma?
a cancer of round cells of the lymphocytic system. it can occur as a primary bone tumour (non-Hogekins) from the marrow or lymphoma and can metastasise to bone.
What is polymyalgia rheumatica?
inflammatory condition causing myalgia at the hip and shoulder girdles
Who does polymyalgia tend to affect?
women over 50
What would blood tests show?
Raised CRP/ESR/PV
What other condition is polymyalgia rheumatica related to?
Giant cell arteritis
What is the treatment for polymyalgia rheumatica?
15mg of prednisolone reduced over 18 months
What is the commonest form of systemic vasculitis?
Giant cell arteritis
What are the symptoms of GCA?
visual disturbances, headaches, jaw claudication, scalp tenderness, fatigue
What is the disease process in GCA?
transmural inflammation of the intima, media and adventitia. patchy infiltration of lymphocytes, macrophages and granulomas with vessel wall thickening leading to ischaemia.
What investigations would be done for GCA?
temporal artery biopsy & bloods (raised ESR/CRP/PV)
What is the treatment of GCA?
if visual impairment: 60mg of prednisolone, if no visual impairment: 40mg of prednisolone.
What is polymyositis?
idiopathic inflammatior myopathy that causes symmetrical proximal muscle weakness
What is the difference between polymyalgia rheumatica and polymyositis?
PR- muscle stiffness but no weakness.
Polymyositis: muscle weakness
What is the pathogenesis of polymyositis?
CD8 T cells and macrophages surround healthy tissue and initiate a cytotoxic response
What are the symptoms of polymyositis?
symmetrical proximal muscle weakness in the upper and lower limbs, myalgia, insidious onset, dysphagia, fever, weight loss, raynaud’s, polyarthritis, SOB, cough
What investigations would be done for polymyositis?
inflammatory markers, serum CK (often raised x10), auto-antibodies, muscle biopsy (shoes different stages of inflammation, necrosis and regeneration)
What antibodies are seen in polymyositis?
ANA, Anti-Jo-1 and Anti-SRP
What is the treatment for polymyositis?
40mg prednisolone or immunosuppressive drugs such as azathioprine or methotrexate
What is dermatomyositis?
similar to polymyositis with cutaneous manifestations
What are the symptoms of dermatomyositis?
V shaped rash over chest, gottrons papules (purple colouring over the skin over the MCP and PIP joints), heliotrope rash and myalgia/muscle weakness
Is there a risk of malignancy in those with dermatomyositis?
Yes- found in 25% 5 years after diagnosis. increased risk of: breast ovarian lung colon oesophageal bladder
What is fibromyalgia?
muscle condition causing widespread muscle pain and fatigue
Who commonly suffers from fibromyalgia?
young and middle aged females
What are the symptoms of fibromyalgia?
persistent widespread pain >3months on both sides of the body, above and below the waist including the axial skeleton, anxiety, depression, IBS, migraines
What is the treatment for fibromyalgia?
education, analgesia
What are the symptoms of SLE?
weight loss, fever, fatigue, arthralgia, myalgia, inflammatory arthritis, avascular necrosis, malar rash, photosensitivity, discoid lupus, oral/nasal ulceration, raynauds, alopecia
What auto-antibody is most specific to SLE?
Anti-dsDNA
What are complement levels like when disease is active in SLE?
Complement levels (C3/C4) are low
What investigations can be done to look for organ involvement in SLE?
urinalysis, CT chest, MRI, echo
What is the treatment for SLE?
skin disease and arthralgia: Hydroxychloroquine, topical steroids, NSAIDs
inflammatory arthritis: azathioprine, corticosteroids
Severe organ involvement: cyclophosphamide & IV steroids
What is Sjogrens?
autoimmune condition characterised by lymphocyte infiltrates in exocrine organs
What are the symptoms of Sjogrens?
ocular dryness, mouth dryness, arthralgia, fatigue, vaginal dryness and parotid gland swelling
How is Sjogrens Diagnosed?
Ocular dryness via Schirmers test, antibodies.
What auto-antibodies are positive for Sjogrens?
Anti-Ro and Anti-La
What is the treatment for Sjogrens?
Lubricating eye drops, pilocarpine, hydroxychloroquine and immunosuppression
What is Pilocarpine?
it is a medication used to treat increased pressure in the eye and dry mouth.
What are the characteristics of systemic sclerosis?
Raynaud’s, fibrosis and atrophy of the skin, excessive collage deposition can cause skin and internal organ changes
What does limited systemic sclerosis involve?
skin involvement generally limited to face, hands and forearms. Organ involvment occurs later
What is the antibody present in limited systemic sclerosis?
anti-centromere antibody
What does diffuse systemic sclerosis involve?
skin changes come rapidly and tend to affect more areas including the trunk and arms. Significant early organ involvement.
What is the antibody present in diffuse systemic sclerosis?
Anti-Scl-70
What is the treatment for Raynauds?
calcium channel blockers, iloprost, bosentan and sildenophil
What is the antibody present in Mixed connective tissue disease?
Anti-RNP
What are the characteristics of Anti-phospholipid syndrome?
Recurrent venous or arterial thrombosis and fetal loss (after 10 weeks)
What are the complications of anti-phospholipid syndrome?
increased frequency of stroke and MI, pulmonary hypertension, organ failure, livedo reticularis
Which antibody is present in anti-phospholipid syndrome?
Anti-Cardiolipin
What is the treatment for anti-phospholipid syndrome?
Warfarin or LMWH for during pregnancy
What are the vessel changes that occur in vasculitis?
vessel wall thickening, vessel stenosis and occlusion of vessels with subsequent infarction
What are the 2 types of large vessel vasculitis?
GCA and Takayasu arteritis
What are the arteries affected in Takayasu arteritis?
Arteries off the branch of the aorta
What is the treatment for large cell arteritis?
40-60mg of prednisolone which is gradually reduced
What are the types of medium vessel vasculitis?
Kawasaki disease, polyarteritis nodosa and Buergers disease
What are the symptoms of Kawasaki disease?
conjunctivitis, rash over the body, adenopathy, strawberry tongue, hands and feet swelling
Which vasculitis can be seen on angiogram as a string of beads?
Polyarteritis nodosa
What are the types of small vessel vasculitis?
GPA, EGPA, MPA, HSP
What are the antibodies for Granulomatosis with polyangiitis?
cANCA +ve and anti-PR3
Where does GPA affect?
nasopharynx, lungs and kidneys causing sinusitis, bloody mucous, saddle nose deformities and difficulty breathing
What vasculitis causes saddle nose deformities?
GPA
What does microscopic polyangiitis cause?
glomerulonephritis
What are the antibodies present in MPA?
pANCA +ve
What antibodies are present in EGPA?
Anti-MPO and anti-PR3
How does Henloch schonlein purpura present?
with palpable purpura which is like little bruises due to fibrosis occuring in the affected vessel over the buttocks and lower legs. Also presents with abdo pain, vomiting and joint pain
Which forms of vasculitis are ANCA positive and how are they treated?
MPA and GPA which can be treated with IV steroids and cyclophosphamide
What is the disease mechanism in Henloch Schonlein purpura?
IgA targets endothelial cells via molecular mimicry
How does alcohol and steroid use cause avascular necrosis?
they alter fat metabolism causing mobilisation of fat in the circulation, capillary system sruggles to maintain normal flow. this promotes coagulation in prone areas of blood. increased fat content also compresses venous outflow causing stasis and ischaemia
Where are common sites for avascular necrosis/
femoral head, scaphoid bone, femoral condyles, head of humerus, capitellum, proximal part of tallus
Is there pain associated with AVN?
there is constant pain or when weight bearing
How does AVN look on imaging?
large wedge shaped area of discolouration & trabeculae without osteophytes in the lacunae.
what is the treatment of AVN?
if the articular surface has not collapsed then drilling under fluoroscopy to decompress the bone. if articular surface has collapsed then joint replacement or fusion is considered in the wrist or ankle bones
What is osteochondritis?
inflammation of bone and cartilage
Who does osteochondritis usually affect and why?
tends to affect children and young adults due to increased physical activity and increased body weight.
What is traction osteochondritis at the tibial tubercle also called?
Osgood Schlatters disease
What is osteochondritis dissecans?
Fragmentation with separation of bone and cartilage within a joint.
What is the treatment of osteochondritis?
damaged bone is replaced with osteotomy, large or unstable fragments of bone are pinned for repair and small fragments are removed arthroscopically
What is a giant cell tumour?
it is a firm small swelling arising from a synovial tendon sheath or joint
what do giant cell tumours look like?
pigmented multinucleated giant cells which have haemosiderin giving them a brown appearance
What is a pigmented villonodular synovitis?
giant cell tumour of tendon sheath occurring in the knee joint
What is a rhabdomyosarcoma?
malignant tumour of skeletal muscle
Where does a synovial sarcoma usually manifest?
around the knee
What is a ganglion cyst?
herniation of synovial fluid at a weak point in the joint capsule or tendon sheath. it is well defined and trans-illuminates
Where is a Bakers cyst found?
popliteal fossa
What type of crystals accumulate in gout?
urate crystals
What are causes of high uric acid?
increased protein intake, increased cell breakdown, renal underexcretion, diuretics, renal failure, excessive alcohol, diet
What is gouty trophi?
painless white accumulations of uric acid which can occur in soft tissues and occasionally erupt through the skin
What is needed for the diagnosis of gout?
joint aspiration for serum urate >7mg
Where is a common site for gout?
The 1st MTP joint
What is the treatment for acute attacks of gout?
NSAIDs (colchicine), coricosteroids, opiods analgesia
What is the treatment for chronic gout?
Allopurinol
What are the X-ray findings for osteoarthritis?
Loss of joint space
Osteophytes
Subchondral sclerosis
Subchondral cysts
Which joints are affected by osteoarthritis?
DIPs, large weight bearing joints, spinal cord
What is the treatment for osteoarthritis?
analgesia, NSAIDs, steroids, education, weight loss, physiotherapy
Which joints are affected in rheumatoid arthritis?
PIPs, MCPs and is symmetrical
What are the hallmarks of RA?
Synovitis, tenosynovitis, pannus formation (inflamed spongy synovium as a result of inflammation and hypertrophy) and bony erosions (increased osteoclast activity)
What is the most specific antibody to RA?
Anti-CCP
What is the management of rheumatoid arthritis?
methotrexate, sulfasalazine, biologics (if 2 DMARDs are unsuccessful) e.g. infliximab
What is the grading score for RA and what are the boundaries?
DAS28
<2.6: remission
>5.1: severe active RA
What is Osteoporosis?
increased bone porosity and decreased bone mineral density
What is the cause of osteoporosis?
increased osteoclastic response after the menopause or decreased oestrogen
What is a Colles fracture?
fracture involving the distal radius where the fractured bone is bent backwards
How is osteoporosis diagnosed?
DEXA scan
What is the treatment for osteoporosis?
calcium supplements, vitamin D, bisphosphonates
What is the mechanism of bisphosphonates?
reduce osteoclast activity. examples include alendronate, riseadronate, etc.
What is the mechanism of strontium?
increases osteoblast replication and decreases osteoclastic activity
What is osteomalacia?
abnormal softening of the bone due to deficient mineralisation of osteoid with decreased phosphate and calcium
What are the causes of osteomalacia?
insufficient calcium, deficiency or resistance to vitamin D, phosphate deficiency, long term anti-convulsant use, chronic kidney disease, inherited disease
What are the symptoms of osteomalacia?
bone pain, deformities from soft bones, pathological fractures, hypocalcaemia, pseudofractures
What is the biochemistry of osteomalacia?
decreased phosphate & calcium. increased ALP
What is the treatment for osteomalacia?
Vitamin D therapy, calcium supplementation and phosphate supplementation
What is hyperparathyroidism?
overactivity of parathyroid glands resulting in increased PTH
What is the cause of hyperparathyroidism?
benign adenoma, hypocalcaemia, decreased phosphate
What is Paget’s disease?
chronic disease of bone causing thickened, brittle and misshaped bone
What causes pagets disease?
viral infection with paramyxoviruses and genetic defects
What is the disease mechanism in Paget’s disease?
potentially due to an exaggerated vitamin D response, there is an increased osteoclast activity which causes osteoblasts to become more active. There is new bone formed but it is brittle
How does Paget’s disease appear on x-ray?
Enlarged bone, thickened cortices, thickened and coarse trabeculae and mixed areas of lysis and sclerosis
What is the biochemistry of Pagets disease?
Raised ALP, normal calcium and normal phosphate
What is the treatment for Paget’s disease?
Bisphosphonates, calcitronin, joint replacement and stabilisation of femoral fractures with long intramedullary nails
What is osteogenesis imperfecta?
it is an autosomal dominant condition causing brittle bone disease via a defect in the maturation and organisation of type 1 collagen in bone
What is the presentation of osteogenesis imperfecta?
multiple fragility fractures, short stature, multiple deformities, BLUE SCLERAE, loss of hearing
What do bones look like in osteogenesis imperfecta?
thin and gracile, thin cortices, osteopenia and fractures heal poorly with poor quality callus
What kind of inheritance is Marfans?
autosomal dominant- mutation or defect in fibrillin gene causing tall stature with disproportionately long limbs and ligamentous laxity
What are the features of Marfan’s?
high arched palate, scoliosis, pectus excavatum, eye problems, aortic aneurysm, cardiac valve incompetence, spontaneous pneumothorax, long limbs
What is Skeletal dysplasia?
Dwarfism
What is the most common form of skeletal dysplasia?
achondroplasia- it is disproportionate
What is the mode of inheritance of achondroplasia?
Autosomal dominant
What is the mode of inheritance of duchenne muscular dystrophy?
X-linked recessive
What is Gower’s sign and what is it associated with?
it is a sign of muscle weakness in young boys with duchenne muscular dystrophy where the patient gets on all 4’s and progresses to put hands on knees before standing up
How is Duchenne Muscular dystrophy diagnosed?
By a raised serum CK and abnormalities on biopsy
What is Beckers muscular dystrophy?
a milder version of duchennes
What mode of inheritance is Ehlers-Danlos syndrome?
Autosomal dominant
How does Ehlers Danlos syndrome present?
joint hypermobilty, vascular fragility and scoliosis
What is cerebral palsy?
neuromuscular disorder caused by an insult to the immature brain before, during or after birth
What is the most common form of cerebral palsy?
spastic
In Ataxic cerebral palsy, where is the insult in the brain?
The cerebellum
What is Spina Bifida?
congenital disorder where 2 halves of the verterbal arch fail to join
What is the mildest form of Spina Bifida and how does it present?
Spina bifida occulta. Spinal cord and roots may tether to vertebral defects causing pes cavus and clawing of the toes. hair may be over the defect.
What is the severe form of spina bifida?
Spina Bifida cystica- contents of vertebral canal herniate through the defect- can be the meninges alone or the spina cord and cauda equina
How is Spina Bifida treated?
defect closed within 48 hours of birth
What is Syndactyly?
fusion of 2 digits
What is polydactyl?
extra digits
What is Fibular Hemimelia?
partial or complete absence of the fibula
What are the causes of brachial plexus injury?
large baby, twin delivery, shoulder dystocia
What is Erbs Palsy?
Injury to C5 and C6 roots