MSK Flashcards
1
Q
Uworld: Muscle Structure and Physiology
What is the function of the T-tubule?
A
Allow depolarization in a uniform manner, allowing synchronized contraction of myofibrils.
2
Q
Pathology: Bone Tumor
Describe Osteosarcoma:
A
- primary bone tumor in children and young adults
- arise in the metaphases on long bones (eg, proximal tibia, distal femur), where bone proliferation is the highest
- causes Periosteal elevation (ei Codman triangle) and a sunburst periosteal reaction
3
Q
Pathology: Bone Tumor
What cells does osteosarcoma rise from?
A
Mesenchymal stem cells or osteoblastic progenitor cells
4
Q
Bootcamp: Pharmacology
What is the MOA of Pembrolizumab?
A
Inhibits PD-1 to improve T lymphocyte immune response
5
Q
A