MSK Flashcards
Bone embryo
Axial/appendicular: mesoderm
Skull: ectoderm, neural crest
Joint embryo
mesoderm
Muscle embryo
mesoderm
smooth muscle: ectoderm
Compact Bone microanatomy
dense portion closer to surface of bones
lamellar bone arranged in sheets
osteons contain Haversian canal w/ artery and nerves
concentric layers radiate out from osteons
lacunae contain osteocytes
osteoblast line outside of the osteons
Spongy Bone microanatomy
inner portion of bone
contain trabecula, interconnected cavities, small amount of lamellar bone (sheets of cartilage), long beam like structure with bone marrow in the spaces between
Fibrous joint microanatomy
fibrous connective tissue
wide sheet of connective tissue
Cartilaginous joint microanatomy
hyaline cartilage or fibrocartilage
Synovial joint microanatomy
outer fibrous capsule
inner synovial membrane: synovial fluid and blood vessels
articular cartilage (hyaline)
Skeletal muscle microanatomy
epimysium-> perimysium ->fascicle -> muscle fiber -> endomysium -> myocyte -> long cylinder cells w/ multiple nuclei under sarcolemma contain t-tubules, myofibrils-> sarcomeres (actin, myosin)
Cardiac muscle microanatomy
striated organized into sarcomeres, branched cells w/ 1-2 centrally located nuclei, intercalated disks (connect myocytes)
endomysium, t-tubules, sarcomere, sarcoplasmic reticulum, pacemaker cells
Smooth Muscle microanatomy
thin and thick myofilaments
fusiform, one nucleus, wrapped in endomysium
no t-tubules, less sarcoplasmic reticulum, caveolae
Where is each muscle type found?
skeletal: attach to bones
cardiac; heart
smooth: walls of hollow organs
Skeletal muscle contraction
motor signal from brain -> spinal cord -> motor neuron release Ach -> Ach binds to receptor -> rapid shift of ion across sarcolemma -> t-tubules bring Ca into myocyte -> sarcoplasmic reticulum releases Ca into sarcoplasm -> Ca causes actin and myosin to pull in on each other -> sarcoplasmic reticulum stores ca -> muscle relaxation
Skeletal muscle regulation
how long ca stays in the sarcoplasm, size of muscle, how many are contracting, how close the actin and myosin filament are to each other, how fast the muscle is contracted (slower = more force bc more myosin head can attach), somatic nervous system
Smooth muscle contraction
AP depolarizes membrane -> Ca enters vis L-type Ca channels-> binds to calmodulin -> activates myosin kinase -> phosphorylates myosin heads to form cross-bridges w/ actin -> activates another smooth muscle
no ATP required and maintain low-level contraction for long periods
Cardiac regulation
autorhythmicity, ANS
Cardiac contraction
Ca flows gap junction -> threshold is reached -> na channels open up -> ions move across cell membrane -> ca flows into cell binding to ryanodine receptor on SR -> Ca released into cell -> bind to troponin c -> tropomyosin slide off -> actin and myosin to bind -> ca removed vi ATP or concentration gradient -> no actin and myosin binding
Vertebrae structure
body arch: pedicles, laminae spinous process 2 transverse process 2 inferior articular process 2 superior articular process
Vertebrae Colum structure
body gets bigger as you go down arch: pedicles, laminae spinous process 2 transverse process 2 inferior articular process 2 superior articular process Cervical 7 thoracic 12 Lumbar 5
Vertebrae column function
support weight, protect spinal cord,
Skull bone function
protects brain
Skull viscerocranium structure
mandible, vomer, ethmoid,
2 of each maxilla, inferior nasal concha, zygomatic, nasal, lacrimal, palatine
Skull neurocranium location
house brain, cranial meninges, blood vessels, and cranial nerves
Skull neurocranium structure
frontal, ethmoid, sphenoid, occipital,
2 of each temporal and parietal