Labs and Imaging Flashcards

1
Q

UA consists of

A
  • color and appearance
  • chemical findings
  • microscopic findings
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2
Q

SX that warrent UA

A

abdominal pain, back pain, frequent or painful urination, blood in your urine, or other urinary problems

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3
Q

what dose red or pink urine mean?

A
  • BPH
  • kidney stones
  • cysts
  • cancer
  • hard exercise
  • beets
  • blackberries
  • rhubabrb
  • rifampin
  • phenazopyridine
  • senna
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4
Q

Orange urine

A
  • Phenazopyridine
  • senna
  • rifampin
  • sulfasalazine (Azulfidine)
  • adriamycin
  • Vitamin A
  • Vitamin B12
  • dehydration
  • cholestasis
  • acute heaptitis
  • alcoholic liver disease
  • oral contraceptives
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5
Q

blue or green urine means

A
  • dyes
  • amitriptyline
  • cimetidine
  • triamterene
  • indomethacin
  • propofol
  • hypercalcemia
  • UTI by some bacteria
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6
Q

dark brown or cola-colored urine

A
  • fava beans
  • rhubarb
  • aloe
  • Chloroquine and primaquine
  • metronidazole
  • nitrofurantoin
  • senna
  • Methocarbamol
  • phenytoin
  • statins
  • UTI
  • exterme exercise
  • viral heaptitis
  • cirrhosis
  • dehydration
  • rhabdomyolysis
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7
Q

cloudy urine

A
  • kidney stones
  • UTI
  • dehydration
  • STI
  • diabetes
  • vaginitis
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8
Q

Urine dip stick includes

A
  • nitrite
  • leukocyte esterase
  • specific gravity
  • pH
  • protien
  • glucose
  • bilirubin
  • urobilinogen
  • ketones
  • blood
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9
Q

Nitrites indicate

A

normal: negative
abnormal: any shade of pink
* Cystitis
* E coli
* Klebsiella
* Proteus
* Enterobacter
* Cirtobacter

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10
Q

Leukocyte Esterase indicates

A

Bacterial infection
Trichomonas
Chlamydia
Balanitis
Urethritis
TB
Bladder tumors
Nephrolithiasis
Foregin bodies
Exercise
Glomerulonephritis

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11
Q

Specific Gravity indicates

A

Hyposthenuria (<1.010)
* Damage to kidney tubule cells (renal tubular necrosis)
* Diabetes insipidus
* Drinking too much fluid
* Kidney failure
* Low sodium level in the blood
* Severe kidney infection (pyelonephritis)

Hypersthenuria (>1.010)
* Adrenal glands do not produce enough hormones (Addison disease)
* Heart failure
* High sodium level in the blood
* Loss of body fluids (dehydration)
* Narrowing of the kidney artery (renal artery stenosis)
* Shock
* Sugar (glucose) in the urine
* Syndrome of inappropriate ADH secretion (SIADH)

Normal: 1.005 to 1.030

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12
Q

Bilirubin

A

Viral hepatitis (Hepatitis A-E)
Alcoholic liver disease (alcoholic steatosis, alcoholic hepatitis, cirrhosis)
Non-alcoholic steatohepatitis
Autoimmune hepatitis
Wilson disease
Hemochromatosis
Dubin-Johnson syndrome
Rotor syndrome
Primary biliary cirrhosis
Ischemic hepatitis
Sarcoidosis
Pregnancy
Drug-induced liver injury
Sepsis
Gallstones
Biliary stricture
Biliary atresia
Choledochal cyst
Cholangitis (bacterial, recurrent pyogenic, primary sclerosing, secondary sclerosing)
Cholangiocarcinoma
Intrahepatic malignancy
Extrahepatic malignancy (lymphoma, pancreatic cancer)
Chronic pancreatitis

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13
Q

Urobilinogen indicates

A

Hepatitis
Cirrhosis
Carcinoma
Hemolytic disorders

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14
Q

Bilirubin findings

A

Trace
Small
Moderate
Large

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15
Q

Urobilinogen findings

A

0.2 mg/dl
1 mg/dl
2 mg/dl
4 mg/dl
8 mg/dl

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16
Q

Protein results

A

trace 10 to 20 mg per dL
1+ (30 mg per dL),
2+ (100 mg per dL)
3+ (300 mg per dL)
4+ (1,000 mg per dL).

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17
Q

Protien causes

A

Minimal change disease
Idiopathic membranous glomerulonephritis
Focal segmental glomerulonephritis
Membranoproliferative glomerulonephritis
IgA nephropathy
DM
Collagen vascular disorders
Amyloidosis
Preeclampsia
Infection
Gastrointestinal and lung cancers
Lymphoma
Drugs
Hypertensive nephrosclerosis
Uric acid nephropathy
Acute hypersensitivity interstitial nephritis
Fanconi syndrome
Heavy metals
Sickle cell disease
Multiple myeloma
Myoglobinuria

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18
Q

Glucose cause

A

DM
Tubular damage

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19
Q

Ketones cause

A

DM

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20
Q

pH cause

A

High: Renal tubular acidosis
Low: DM or renal/bladder calculi

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21
Q

Blood cause

A

Renal calculi
Glomerulonephritis
Pyelonephritis

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22
Q

Hyaline cast

A

Conglomerations of protein indicating proteinuria

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23
Q

Hyaline cast cause

A

Acute:
Following strenuous exercise
Orthostatic proteinuria
Fever

Chronic:
Glomerulonephritis
Pyelonephritis
CHF
Chronic renal failure

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24
Q

RBC casts

A

Clump of RBC due to breakdown of glomerulus and stasis

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25
RBC casts cause
Glomerulonephritis SBE Subacute bacterial endocarditis Renal infarcts Vasculitis Sickle cell anemia SLE Malignant HTN Goodpasture’s syndrome PSGN
26
WBC casts cause
Acute pyelonephritis Glomerulonephritis Lupus nephritis
27
Renal tubular epithelial cell casts
Nephrosis Amyloidosis Heavy mental or other poisoning Glomerulonephritis Acute tubular necrosis Pyelonephritis
28
Waxy or broad casts cause
Chronic renal failure
29
Crystals cause
Nephrolithiasis Uric acid
30
Microalbumin cause
Moderate: Early detection of kidney disease High: Kidney failure
31
24-h urine protein findings
N 150 mg/24 h Proteinuria 150-500 mg/24h >2000 mg/24 h >3500 mg/24h
32
24-h urine protein cause
Glomerular Nephrotic syndrome Renal disease HTN Toxicity from heavy metals/ solvents Preeclampsia/eclampsia
33
Fractional excretion of sodium findings
Increased sodium in urine = intrinsic kidney path Normal sodium = prerenal cause FENa > 2 damage to tubules FENa < 1 decrease blood flow
34
Creatinine clearance findings
24-h urine collected and blood draw M 90-139 ml/min F 80-125 ml/min
35
Creatinine clearance cause
Tubular damage Glomerulonephritis Kidney failure
36
Albumin creatinine ratio findings
30-300 mg/day
37
Albumin creatinine ratio cause
Kidney damage in pt with DM
38
Uroflowmetry or “Uro Flow Test” findings
Measures voided volume, voiding time, average flow rate, max flow rate (Qmax) N urine volume >200ml over 15-30 sec N peak flow: Male 20-25 ml/s, Female 20-30 ml/s
39
Uroflowmetry or “Uro Flow Test” cause
Decrease: Suggests bladder outlet obstruction (BOO) (most common in M), or weak detrusor muscle contraction Increase: Suggests bladder spasticity Intermittent flow: Straining to overcome resistance (sphincter tone)
40
Cytometry findings
Assesses bladder storage capacity, pressure as bladder fills, how full when urge triggered Detrusor contractions before bladder fills to 150-250ml is abnormal
41
Cytometry indications
neurogenic bladder, MS, spinal cord injury, diabetes, BPH
42
Pressure Flow Study
Measures intravesical and detrusor muscle pressure required for voiding and flow rate (ml/s) Normal voiding pressure not > 30cm of H2O pressure
43
Pressure Flow Study cause
If bladder pressure is >50cm of H2O along with low urine flow: urethral overactivity (detrusor-sphincter dyssynergia) or urethral stricture or BOO (bladder outlet obstruction) may be cause
44
Postvoid Residual Measurement findings
Measures amt of urine in bladder after micturition PVR >100 ml is abnormal
45
Urethral Pressure Profile finding
Measures intraluminal pressure along length of urethra (usu done in female-body pt)
46
Urethral Pressure Profile cause
obstruction or incontinence High pressure = Resistance Low pressure = Compromised function
47
Electromyography findings
In Females, it can assess pelvic floor or periurethral muscle activity for abnormal contraction or relaxation contributing to urinary obstruction or incontinence. Can also check electrical activity in the bladder neck
48
CBC with differential contains
* RBCs * WBCs * platelets * hemoglobin * hematocrit * MCV * MCH * MCHC * RDW
49
RBCs findings
increased * polycythemia vera * smoking * dehydration * cor pulmonale * renal cell carcinoma * hypoxia * congential heart disease * pulmonary fibrosis * medication normal decreased * anemia * bleeding * multiple myeloma * leukemia * malnutriton * pregnancy * hemolysis * B12/6/9 deficency * iron and copper * overhydration * medications
50
Hemoglobin cause
decreased * bone marrow defects * renal disease * cell destruction * blood loss * hemogloninopathies * lead poisoning * iron deficiency * pregnancy * over-hydration increased * polycythemia vera * renal tumors * COPD * pulmonary fibrosis * heart disease * dehydration
51
hypochromasia
increase in the red cells central pallor which occupies more than the normal third of the red cell diameter found in: iron deficency and thalassaemia
52
hematocrit
the volume of erythrocytes expressed as a precentage of the volume of whole blood
53
hematocrit cause
increased * erythrocytosis * congenital heart disease * polycythemia vera * dehydration * severe COPD decreased * anemia * hemoglobinopathies * hemolytic anemia * hemorrhage * nutrient deficiencies * bone marrow failure * prosthetic valves * renal disease * pregnancy * blood cancers and malignancies
54
hemoglobin interfering factors
very high WBC counts severe lipidemia RBC abnormalities increased turbidity increased bilirubin
55
hematocrit interfering factors
RBC size extremely high WBC counts over and under hydration pregnancy decreases due to hemoduilution high altitudes increase due to hypoxia post-hemorrhage values not reliable for several hours drugs
56
MCV (mean corpuscular volume)
average volume of RBCs how big they are decreased MCV: microcytic RBCS <80 increased MCV: macrocyctic RBCs >100 normal: normocytic
57
MCV interfering factors
* high WBC * high platelets * agglutinated RBCs * RBC fragments
58
mean corpuscular hemoglobin concentration (MCHC)
ratio of the average concentration of hemoglobin in a given volume of RBCs normal MCHC: 32-36 normochromic decreased <30 hypochromic
59
normocytic, normochromic anemia
chronic illness renal disease acute blood loss aplastic anemia autoimmune hemolytic anemia
60
microcytic, hypochromic anemia
iron deficiency sideroblastic lead poisoning anemia of chronic disease (later stage) thalassemia
61
macrocytic, normochromic anemia
vitamin B12 or folate deficiency pernicious anemia side effects of chemotherapy myelodysplastic syndrome acute myelogenous leukemia
62
Platelet count
thrombocytopenia: <150,000 thrombocytosis: > 400,000 thrombocythemia: > 1,000,000
63
platelet count cause
thrombocytopenia * hypersplenism * hemorrhage * leukemia * myelofibrosis * thrombotic thrombocytopenia purpura * ITP * aplastic anemia * graves diasese * pre-eclampsia * DIC * SLE * pernicious anemia * hemolytic anemia * cancer chemotherapy * severe infection * drug reactions thrombocytosis * malignant disorders * polycythemia vera * acute infections * sepsis * post-splenectomy * rheumatoid arthrtis * iron deficiency * primary thrombocytosis
64
Platelet interfering factors
high altitude strenous exercise prior to menses estrogen drugs
65
WBC findings
total WBC count ER low: less than 500 per mm high: greater than 30,000
66
WBC cause
leukocytosis * infections * leukemic neoplasia * other malignancy * trauma * stress * hemorrhage * tissue necrosis * inflammation * dehydration * thyroid storm * post splenectomy leukopenia * drug toxicity * bone marrow depression/failure * severe infections * dietary deficiencies * marrow aplasia * marrow infiltration * autoimmune disease * hypersplenism * chemotherapy
67
differential WBC count
normal Neutrophil 60% lymphocyte 30% monocyte 6% eosinophil 3% basophil 0%n
68
Neutrophils cause
neutrophillia * acute infection * trauma * physical/emotional stress * inflammatory disorders * metabolic disorders * myelocyctic leukemia * cushing's sundrome neutropenia * overwhelming bacterial infection * viral infection * aplastic anemia * radiation therapy * addisons disease * chemotherapy * dietary deficiency
69
eosinophils cause
eosinophilia * parasitic infections * allergic reactions * asthma, hay fever * hodgkin's disease * eosinophil myaliga syndrome * eczema * leukemia * autoimmune disease * ovarian cancer eosinopenia * cushing syndrome * endogenous or exogenous cortisol excess * stress
70
Basophils cause
basophilia * myleoproliferative disease: polycythemia * granulocytic leukemia * chromci muelocytic leukemia * hodgkin's lumphoma Basopenia * acute phase infection * hyperthyroidism * stress reactions * prolonged steroid therapy
71
lymphocytes cause
lymphocytosis >4000 * viral infections: CMV, HIV * pertussis, TB * lymphocytic leukemia * multipe myeloma * infecitous mononucleosis/EBV * infecitous hepatitis * hypoadrenalism (addison's disease) Lymphopenia <1000 * myelocytic leukemia * hodgkin's disease * sepsis * immunodefiency diseases * SLE * adrenocorticosteroids and chemotherapy * radaition
72
monocytes cuase
monocytosis >500 * EBV * TB * subacute bacterial endocarditis * syphilis * chronic UC * parasites (malaria) * monocytic leukemia moncytopenia <100 * prednisone * HIV * hairy cell leukemia * aplastic anemia
73
Mean platelet volume (MPV) cause
average volume of a population of platelets
74
MPV cause
increased * valvular heart disease * ITP * sepsis * severe hemorrhage * B12/folate def * myelocytic leukemia decreased * aplastic anemia * cancer chemotherapy * wiskott-aldrich syndrome
75
bleeding time cause
increased * thrombasthenia * bernard-soulier * storage pool disease * asprin * platelet count <75,000 * von wilebrand disease * uremia * liver failure
76
Prothrombin time
evalutates extrinsic system Inceased * deficency of VII, X, V, prothrombin, or fibrinogen * vit K def * liver disease * warfarin * DIC * heparin
77
International normalised ration (INR)
PT is expressed as a ratio of prothrombin clotting time for patient plasma divided by time for control plasma INR 1 is normal >1 clotting time is elevated
78
activated partial thromboplastin time (aPTT)
evaluates intristic system increased * def in VIII, IX, XI, or XII
79
thrombin time
measurement of the conversion of fibriongen to fibrin
80
Factor assays
factor IX factor VIII
81
Direct Coomb test (Direct antiglobulin test)
used to detect antibodies that are stuck to the surface of red blood cells abnormal: * autimmune hemolytic anemia * chronic lymphocytic leukemia * erythroblastosis fetalis * infectious mononucleosis * mycoplasma infection * syphilis * SLE * tranfusion reactions
82
Indirect coombs test
looks for antibodies that are floating in the blood, to determine a reaction to blood transfusion abnormal * Erythroblastosis fetalis * Incompatible blood match
83
blood typing
measures the antigen and markers on the surface of RBCs ABO RH C or c, D or d, E or e Kell K or k Duffy Fya, Fyb, FY kidd Jk, Jka, Jkb, Jkab
84
erythrocyte sedimentation rate
sedimentation rate, non-spefic measurment of inflammation
85
erythrocyte sedimentation rate cause
* RA * psoriatic arthritis * gout * reactive arthritis * sarcoidosis * sjogren's syndrome * calcium pyrophsophate depisition disease * urticaria * ankylosing spondylitis * juvenile RA * acute prostatitis * crohn's disease * SIBO * UC * polymyalgia rheumatic * osteoarthritis * gastroenteritis
86
Comprehensive metabolic panel contains
* glucose * calcium * sodium * potassium * carbon dioxide * chloride * albumin * total protien * ALP * ALT * AST * bilirubin * BUN * creatinine
87
glucose on CMP
increased * daibetes * hyperthyroidism * pancreas disorders * stress decreased * side effect of medications * not eating enough * more physically active * liver disease * kidney disease * hypothyroidism * alcohol use disorder * Underactive adrenal or pituitary,
88
calcium on CMP
total calcium: bound and free increased * hyperparathyroidism * cancer of the bone * paget's disease * too much Vit D decreased * malnutriton * liver disease * hypoparathyroidism * Vit D, mag, calcium def * pancreatitis * kidney disease
89
Sodium on CMP
increased hypernatermia * dehydration * gastroenteritis, vomiting, prolonged nasogastric drainage, burns, and excessive sweating * intrinsic renal disease, post-obstructive diuresis, and with the use of osmotic or loop diuretics * daibetes insipidus * diabetic ketoacidosis Hyponatermia * diuretics * kidney disease * decreased sodium intake * diuretics * SIADH * heart faliure * stroke, hemorrhage, infection, trauma, and psychosis, * ADH tumor * drugs * pneumonia * hypothyroidism * adrenal insufficency * HIV
90
potassium
Hyperkalemia * kidney disease * diet * medications * addisons * burns or severe injuries * diabetes hypokalemia * alcohol * chronic kidney disease * daibetic ketoacidsosis * diarrhea * diuretics * laxatives * excessive sweating * folic acid def * primary aldosteronism * vommiting
91
carbon dioxide
increased hypercapnia * cushing's syndrome * kideny faliure * COPD * sleep apnea * stroke * hypothyroirism * MS * ALS * muscular dystrophy * spinal cord injuries * flail chest * ankylosing spondylitis * tetanus * botulism * pulmonary embolism * vascular disease * dehydration decreased * addison disaese * diabetic ketoacidosis * shock * kidney disorders
92
chloride
increased * addison disease * carbonic anhydrase inhibitors * diarrhea * ethylene glycol poisoning * ketoacidosis * kidney disease * lactic acidosis * methanol poisoning * renal tubular acidosis * salicylate toxicity * ureteral diversion * cancer * hypoglycemia * alcohol * seziures decreased * bartter syndrome * burns * congestive heart failure * cushing syndrome * dehydration * excessive sweating * hyperaldosteronism * COPD * asthma * pulmonary fibrosis * scoliosis * drugs * sleep apnea * SIADH * vomiting
93
albumin
increased * dehydration * diarrhea decreased * infection * sepesis * surgery * IBD * kidney disease * cirrhosis * fatty liver disease * liver cancer * hepatitis A, B, or C * malnutrition * hypothyroidism
94
total protien
increased * multpile meyeloma * waldenstrom disease * HIV * hepatitis B or C decreased * kidney * liver * malnutriton * celiac disease * crohn's disease
95
ALP
increased * cholestasis of pregnancy * cirrhosis of liver * hepatitis * biliary atresia * biliary stricture * cholangiocarcinoma and pancreatic head adenocarcinoma * mononucleosis * bone metastasis * paget's disease of the bone * osteogenic sarcoma * fractures that are healing * hyperparathyroidism * hyperthyroidism * osteomalacia * Vit D def * celiac disease decreased * malnutrition * zinc def * mag def * hypothyroidism * hypophosphatasia * Wilson disease.
96
ALT
increased * Alcohol-induced liver injury. * Fatty liver disease * Hepatitis * Cirrhosis * Taking medications that are toxic to your liver. * Liver tumor or liver cancer. * Liver ischemia * Hemochromatosis * Mononucleosis decreased * B6 def * chronic kidney disease
97
AST
increased * Alcohol-induced liver injury. * Hepatitis * Cirrhosis * Taking medications that are toxic to your liver. * Liver tumor or liver cancer. * liver ischemia * Heart attack * Mononucleosis * Muscle disease. * Pancreatitis. * burns * seizures * surgerys including heart * intense exercise decreased * Vit B6 def * chronic kidney disease
98
in CMP bilirubin
increased * erythroblastosis fetalis * hemolytic anemia * sickle cell disease * premature birth * mononucleosis * wilson disease * Crigler-Najjar syndrome * * Transfusion reaction * cirrhosis * hepatitis * gilbert disease * biliary stricture * cancer of pancrease or gallbladder * gallstones decreased
99
BUN
increased * dehydration * burns * medications * urinary tract obstruction * congestive heart failure * recent heart attack * Gastrointestinal bleeding * Shock * high protein diet * kidney disease decreased * malnutrtion * lack of protien * liver disease * overhydration
100
creatinine on CMP
increased * obstruction of urinary tract * kidney damage, faliure, infection, or reduced blood flow * eclampsia * preeclampsia decreaased * malnutriton * muscular dystrophy * liver disease * low protien diet
101
total serum testosterone
decreased * klinefelter syndrome * testicle injuries cancer treatments, such as chemotherapy and radiation stress AIDS alcohol use disorder kidney disease cirrhosis of the liver pituitary gland conditions autoimmune disease infection obesity metabolic syndrome using certain medications increased * tumor * steroid use * congenital adrenal hyperplasia * PCOS * ovarian cancer * disorder of pitutary gland
102
FSH