MS pathologies Flashcards
Types of ARTHRITIS ?
Osteoarthritis (OA)/Degenerative Joint Disease (DJD)
Rheumatoid Arthritis (RA)
Gouty Arthritis
Septic Arthritis
Osteoarthritis (OA) aka Degenerative Joint Disease (DJD) patho ?
Progressive degeneration and loss of articular cartilage.
Underlying bone is damaged, with formation of new bone (osteophytes) at margins.
What is the key in dx OA ?
key thing of OA is osteophytes - dx degenerative condition (different from the others)
Is OA non inflammatory to inflammatory ?
NON - inflammatory
OA/DJD sxs ?
Slow onset, brief stiffness in AM or after overuse or inactivity
No generalized sxs of fatigue or malaise - not systemic disease just in joints itself
Usually additive
Commonly affects knees, hips, spine, wrists, DIP> PIP, not MCP ( helps you distinguish if from RA cause RA does not have DIP)
**athletes and obese cause pounding on joints , RA is more symmetrical **
OA / DJD PE, signs ?
↓ AROM and PROM, crepitus
Rarely warm or red (cause it is not inflammatory)
Bony enlargement (from osteophytes) - new simulated bone
Heberden’s nodes – nodules at DIP jt.
Bouchard’s nodes –nodules at PIP jt.
OA: Heberden’s nodes – nodules at ___ jt.
DIP
**osteophyte formation but they are not red swollen tender and stuff they are just hard a painless and the MCP joints are spared **
OA: Bouchard’s nodes –nodules at ___ jt.
PIP
OA / DJD - Treatment ?
NSAID’s
Pain meds (Tramadol) - opoid
Joint injections
Arthroplasty
rooster cone into the mixer and they inject it into the joint (synvisk)
RA patho ?
Autoimmune disorder, unknown trigger, slow onset
Chronic inflammation of synovial membrane
-secondary erosion of cartilage and bone - damage to ligaments and tendons
**more slow onset
and they feel really crappy cause it is systemic and inflammatory
erosion of cart. and bone and damage to ligaments and tendons **
RA sxs. ?
Symmetrically additive - usually both knee
Insidious onset, becomes chronic with exacerbations and remissions
Stiffness, lasting 1+ hours in AM or after inactivity (take them a while to get p and going)
Generalized sxs of weakness, fatigue, weight loss, fever
Females > Males
RA PE, signs ?
↓ AROM and PROM
Tender and warm joints, seldom red
+/- subcutaneous nodules on ulnar surface
PIP and MCP most, rarely DIP
Ulnar deviation of fingers
Swan neck deformity
Boutonniere deformity (less common)
Rheumatoid arthritis – swan neck and boutonniere deformities ?
top right is the swan hyper extension
inter osseous muscle atrophy cause they are not using the muscles look at bottom pic
Acute gouty arthritis what crystal in the joint cause what type of reaction ?
Monosodium urate crystals in joint cause an inflammatory reaction
Acute pseudogouty arthritis what crystal in the joint cause what type of reaction ?
(Pseudogout – calcium pyrophosphate crystals)
Acute gouty arthritis - symptoms ?
Sudden onset of severe pain, often 1st MTP joint
but also instep, ankles, knees, elbows ( classically big toe)
+/- hx of recent, excessive intake of food (purines - high protein - shrimp) or ETOH, fasting or injury
Usually one joint on first episode
Repeat episodes become more frequent and more severe
Acute gouty arthritis PE, signs ?
Very tender, hot and red
No stiffness, ↓ ROM is due to pain
Can be mistaken for cellulitis, septic arthritis
**looks like septic arthritis **
Acute gouty arthritis labs ?
↑ serum uric acid (but can be normal in 30% of patients) -
not diagnostic though - gives us a clue
What is dx study for GOUT ?
Definitive Dx – aspirate joint fluid
Acute gouty arthritis tx ?
NSAIDs - acute
Education re: prevention ( avoid triggers)
recurrent / chronic GOUT - allopurinol
Septic arthritis is a MS ____________ .
emergency
Can leave a permanent functional disability
**needs to be dx really quickly with bone destruction cause it really does not grow back **
Septic arthritis (SA): Bacteria in a joint causes ?
vascular congestion - taking up more space
increased synovial fluid - more space being taken up
destruction of articular cartilage
destruction of bone within one week of
onset - losing bone in one week
SA: Bacteria comes from one of 3 routes, which are ?
Hematogenous - IV drug user, LUPUS, strep or UTI ( small infections that can cause it )
Direct inoculation - severe trauma, surgery
Contiguous - someting nearby like a soft tissue abcess that erodes into the joint
SA sxs ?
rapid pain ( look like GOUT),
swelling
↓ROM