Maternal Physiology / Normal Pregnancy and Prenatal Care / Imaging in Obstetrics Flashcards
Maternal Physiology
Pregnancy changes anatomy, physiology and biochemistry
Affects normal lab values
Affects medication dosing
Cardiovascular System 1 ?
As uterus enlarges, heart rotates
Apical impulse shifts laterally
Heart size increases by 12%
Blood plasma volume increases ~50% - Varies by Size of woman Number of prior pregnancies Number of fetuses
Cardiovascular System 2 ?
Cardiac output increases 40%
Stroke volume increases 25-30%
-Sensitive to maternal position
-Lateral recumbent
-Supine -they are compressing the vena cava
so lay on right or left side
Cardiovascular System 3 ?
Systemic arterial pressure decreases initially (until 24-28 weeks)
Venous pressure increases in legs
-Pressure on inferior vena cava and common iliac veins
-Edema
-Varicosities
feet swelling is normal but arms not so much
Cardiovascular System 4 ?
Blood flow distribution
Increased flow to uterus, kidneys, breast and skin - helps dissipate the heat
Strenuous exercise
- Diverts blood flow to large muscles
- Okay for conditioned mothers
- For nonconditioned, can decrease uteroplacental perfusion to the fetus
Cardiovascular System 5 ?
90% of gravidas have systolic ejection murmurs
Increased CO
Decreased blood viscosity
Pulmonary System 1 ?
Engorgement of nasopharynx, larynx, trachea and bronchi
Increased vascular markings on CXR
Diaphragm elevates 4 cm - SOB
- Reduced total lung capacity
- ribs flare out a bit more ( look below too)
Increased thoracic circumference
Decreased total lung capacity
Increased tidal volume
-Decreased reserve and residual volume
Renal System 1 ?
Kidney lengths enlarge by 1-1.5 cms
Ureters elongate and widen - curve around uterus
Collecting system can contain 200 mL
- Increased risk of UTI’s
- hold more volume but increase risk of UTI
Back to normal 4 days postpartum
Renal System 2 ?
Blood flow to kidneys increases by 50-85% during first half of pregnancy, lower later
Urinary flow increases two-fold in LATE pregnancy when in lateral recumbent position ( compared to supine)
Medications cleared by the kidney faster
Half of pregnant women will have glucosuria sometime during pregnancy
-NL also contributes to UTI rate
Renal System 3 ?
Early in pregnancy, hormones contribute to increased urinary frequency
Bladder capacity actually enlarges
Later in pregnancy, frequency due to enlarged uterus (pressure)
Gastrointestinal System ?
Stomach pushed upward
Bowel pushed back, to sides and up
Increased salivation (due to nausea?)
Gums may hypertrophy, bleed
-hormones , or even OCP
Increased GERD, esp first trimester
-more gastrin being produced and esophageal peristalsis being decreased
Increased constipation in later months
-cause slower transit time of stool
Increased risk of gallstone formation
-cause of bile stasis , GB disease
Hematologic System 1 ?
Red cell mass expands by 33%, even more with iron supplementation
Greater plasma increase – anemia of pregnancy cause of dilution factor
Active transport of iron to fetus
Fetus generally not anemic, even if mother is severely anemic
Hematologic System 2 ?
WBC’s 5000-12,000 in third trimester
not infection
20,000-25,000 during labor is normal
Mainly polymorphonuclear cells
- Basophils decrease slightly
- Eosinophils unchanged
Platelet production increases, but so does consumption = thrombocytopenia
-Resolves with delivery
Skin: Hyperpigmentation ?
Linea nigra
Chloasma - “mask of pregnancy”
Skin: Striae gravidarum ?
“stretch marks”
Abdomen, breasts, thighs, buttocks
Decreased collagen adhesiveness and it just pulls apart
Genetic predisposition
No effective treatment
Skin continued ?
Spider angiomas
Palmar erythema- cause more heat through the hands trying to be released
Cutis marmorata - vasomotor instability
Hemorrhoids
Brittle nails with grooves (Beau’s lines)
-trauma to the body and the blood etc go else were causing this
Thickened hair (ends 1-5 months postpartum and shedding begins
Metabolism: Increased nutritional requirements ?
Rest more
Increased appetite (for some)
Pica (rare) - dirt
Metabolism: Weight gain ?
Uterus and contents ( fetus)
Breast enlargement
Blood and water volume 6.8L
Average weight gain is 27.5 lbs
Placenta ?
Purpose is physiologic exchange between fetal organs and maternal tissue
Oxygen and nutrients to fetus
CO2, urea, catabolites back to the mother
Placenta: Cotyledons ?
Cotyledons – 12-15 subunits of the placenta - tents of blood where the blood collects and during contraction they collapse
At height of contraction, cotyledons are mainly devoid of blood flow. In uterine tetany, fetal hypoxia develops
Placenta and Placental-Fetal Unit: Produces increasing amounts of steroids in late ?
first trimester
Placenta and Placental-Fetal Unit: Fetal adrenal cortex _______ than adult
larger
helps with fetal development and growth , maturation and delivery
Placental Secretions ?
Human chorionic gonadotropin- hCG
Properties similar to LH from pituitary
Alpha subunit common to all glycoproteins
Beta subunit is specific to the hormone
HcG secretions: Measurement of β-hCG detects pregnancy______ after fertilization ( qualitative)
6-12 days
HcG secretions: Levels peak at ______ gestation
60-90 days
then we look for quantitative and if it is still increasing and increasing then it could be ectopic
Placental Transport of Drugs: Few substances that won’t cross the “placental barrier” ?
Heparin
Insulin
these wont cross cause Too large of molecules
Umbilical Cord: Connective tissue of cord is called ?
Wharton’s jelly
Umbilical Cord: ___arteries, ___ vein twisted around each other
Two
one
Umbilical Cord: _______ carry blood from fetus to the mother
Arteries
Umbilical Cord: ____ returns blood to the fetus
Vein
Umbilical Cord: Average diameter ?
12 mm
Umbilical Cord: Average length ?
50-60 cms
Umbilical Cord: Nuchal loops around baby’s neck 25% of _________________ deliveries
spontaneous vertex
Umbilical Cord: Short cord related to _______________ maybe a shorter umbilical cord
oligohydramnios
not enough amniotic fluid
Umbilical Cord: True knots in __ of deliveries – can lead to fetal demise
1%
Umbilical Cord: At delivery, a portion of the cord should be kept for ?
cord blood gas sampling
more accurate then a APGAR score and it is preserved for several hours
Normal Pregnancy and Prenatal Care definition ?
Pregnancy defined as the physiologic process of a developing fetus within the maternal body
Gestational age is the amount of time since first day of ____
LNMP
(precedes fertilization by 2 weeks)
Assume a 28 day cycle
Gestational age expressed in ?
Expressed in completed weeks
__ weeks to term pregnancy
40
_________________ age is the age of the conception, calculated from time of implantation
Developmental/fetal
Naegele’s Rule calculates ?
estimated due date (EDD)
Naegele’s Rule ?
Add 7 days to first day of LNMP
Subtract 3 months
Add 1 year
Ex: First day of LNMP 5/1/15
Gestation: Divided into __ trimesters, each __ calendar months
3
3
Gestation: First trimester has two parts ?
Embryonic period
Fetal period
Embryonic period: ____weeks gestational age
2-10
Embryonic period: Most sensitive to ?
teratogens
- *sometimes people dont know they preggo yet and still drink alcohol etc .
- *
Fetal period: __ weeks after FDLNMP
10
8 weeks after fertilization
Nulliparous - ?
never pregnant
Primiparous - ?
first pregnancy
Multiparous - ?
delivered more than one child
Gravid = ?
pregnant
Gravida = ?
total number of pregnancies, regardless of outcome
delivered pregnancy or not
Parity= ?
number of births
Parity includes what type of births ?
full term
preterm
abortions
living children
Preterm births: Weighing ____ or more, at OR beyond __ completed weeks, alive or dead
500 g
20
Abortions: Ending before __ weeks, induced or spontaneous
20
Twins = ___ gravid event, but ___ parity
one
two
Ex: G2 P3 Ab 0 ?
(had twins once)
Ex: G2 T1 P0 A0 L1 ?
(currently pregant)
Live birth – ?
evidence of life
Infant: Live-born human, from moment of birth until ?
1 year of age
Preterm infant: Born at _____ completed weeks gestation
20 -37
Term infant: Born between ______ and ______ weeks
37 0/7 and 42 0/7
Postterm infant: Born after __ weeks
42
Large for gestational age (LGA) – aka ?
macrosomia - “big body”
Beyond 90th percentile
LGA baby are prone to ?
gestational DM are prone to this
cephalopelvic disproportion
Low-birth-weight infant – ?
2500 g or less
Abortion – based on age or weight: Expulsion of ____________________ with or without fetus
complete or partial placenta
Abortion – based on age or weight: Expulsion of fetus, alive or dead weighing less than _____ or less than __ completed weeks
500 g
20
Embryo –until __ weeks gestation
10
Fetus – ___ weeks
10+
Neonatal period ?
Birth to 28 days of life
Infant is a newborn, a neonate
Perinatal period: __ weeks gestation to 7 days of life
28
before and after birth
Pregnancy Symptoms and Signs: Nausea/vomiting
?
50% of pregnancies
2 weeks until 13-16 weeks
Small, frequent meals, emotional support
Extreme – Hyperemesis gravidarum
Pregnancy Symptoms and Signs: Mastodynia ?
Tingling to pain
Caused by hormones
Pregnancy Symptoms and Signs: Breast engorgement ?
Fullness, esp in primips ( first pregnancies)
Montgomery’s tubercles
Periareolar veins ( venous engorgement )