MRCP Oncology

Question 1

Most common oesophageal carcinoma in the LOWER third

Answer 1

Adenocarcinoma (associated with acid reflux and Barrett’s)

Question 2

Lung cancer most associated with hypercalcaemia

Answer 2

Squamous cell (secrete PTHrP)

Question 3

Tumour marker to assess prognosis/disease burden in myeloma

Answer 3

Beta-2 microglobin

Question 4

Adjuvant chemotherapy for high grade ovarian cancer

Answer 4

Carboplatin and placitaxel

Question 5

First line chemotherapy for small cell lung cancer

Answer 5

Cisplatin and epotoside

Question 6

Bladder cancer associated with schistosoma haematobium

Answer 6

SQUAMOUS cell carcinoma

Question 7

Highest risk of developing which malignancy in Cowden syndrome?

Answer 7

Breast Ca
(mutation of PTEN gene on chromosome 10)
(also renal, endometrial and colorectal)

Question 8

Curative treatment of renal cell carcinoma

Answer 8

Surgical removal ie nephrectomy

Question 9

Hormones used to monitor for recurrence and measure disease burden in testicular cancer

Answer 9

AFP, LDH, bHCG

Question 10

Paraneoplastic (breast, gynaecological malignancies) causing ataxia - which antibody

Answer 10

Anti-Yo

Question 11

What is cholangiocarcinoma?

Answer 11

BILE DUCT cancer

Question 12

Most specific tumour marker in testicular seminoma

Answer 12

bHCG

Question 13

Follow-up for low-grade dysplasia Barrett’s

Answer 13

Repeat OGD 6 months

Question 14

Diarrhoea and mucositis (ie toxicity) following first dose 5-FU

Answer 14

Deficiency in DPD (catabolising) enzyme

Question 15

Glucagonoma 4 D’s

Answer 15

Diabetes
Dermatitis (necrolytic migratory erythema)
Depression
DVT

Question 16

Test to identify patients at high risk of developing tumour lysis syndrome?

Answer 16

LDH (signifies increased cell turnover)

Question 17

Apart from asbestos what is another independent risk factor for developing mesothelioma?

Answer 17

Significant radiation exposure

Question 18

Treatment (both symptomatic and disease burden) of carcinoid

Answer 18

Somatostatin analogues (octreotide, lanreotide)