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MRCP > MRCP Haematology > Flashcards

MRCP Haematology Flashcards

1
Q

Microcytic anaemia, raised HbA2 (>3.5%)

A

Beta thalassaemia trait

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2
Q

Two main complications of polycythaemia vera

A

Thrombosis and bleeding

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3
Q

Bleeding prophylaxis in patient with vWD

A

DDAVP (desmopressin) and tranexamic acid

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4
Q

Two commonest causes of gross splenomegaly

A

CML, myelofibrosis

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5
Q

Blood film seen in myelofibrosis

A

Leucoerythroblastic cells, tear drop cells

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6
Q

Anaemia & marrow biopsy showing fatty bone marrow

A

Aplastic anaemia

AI attack against haematopoietic stem cells

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7
Q

Intensity and duration of anticoagulation in antiphospholipid syndrome?

A

INR 2-3, lifelong

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8
Q

What vitamin helps with the absorption of oral iron?

A

Vitamin C

Reduces iron from ferric to ferrous form

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9
Q

Empirical treatment of neutropaenic sepsis

A

Tazocin (piperacillin & tazobactam)

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10
Q

Red cells showing osmotic fragility

A

Hereditary spherocytosis

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11
Q

Underlying cause of haemolysis in G6PD deficiency

A

Reduced levels of NADPH

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12
Q

APTT & PT in anti-phospholipid syndrome

A

APTT prolonged

PT NORMAL

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13
Q

Tissue sampling required to make diagnosis of lymphoma

A

Lymph node extraction & biopsy.

FNA not adequate!

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14
Q

Tests for determining prognosis in myeloma

A

Albumin and B2-microglobulin

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15
Q

What surface receptor is the target for immunotherapy in lymphoma?

A

CD20

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16
Q

Best test to confirm invasive aspergillosis

A

Galactomannan

17
Q

Translocation in acute promyelocytic leukaemia

A

t(15;17)

18
Q

Anaemia + gallstones = ?genetic condition

A

Hereditary spherocytosis

19
Q

Bleeding prophylaxis in vWD pre dental procedure

A

Desmopressin

20
Q

Treatment of APML (often presents with DIC)

A

All-trans-retinoic acid (vitamin A derivative)

21
Q

Infection prophylaxis for people taking fludarabine

A

Co-trimoxazole

fludarabine is treatment for CLL

22
Q

Pathophysiology behind warfarin induced skin necrosis

A

Protein C deficiency (it is vit K dependent and rapidly falls on commencing warfarin leading to paradoxical prothrombotic state)

23
Q

Peripheral blood film blast cells, gum hypertrophy, splenomegaly

A

AML (Auer rods also)

24
Q

Lymphadenopathy, anaemia, smudge/smear cells on blood film. What investigation? Whats the diagnosis?

A

Diagnosis: CLL
Investigation: Immunophenotyping

25
Q

Acute treatment of hyperviscosity syndrome

A

Plasmapheresis

26
Q

Bone marrow aspiration showing lymphoplasmacytoid cells

A

Waldestrom’s macroglobulinaemia

27
Q

Dry bone marrow aspirate, bone marrow biopsy - fried egg appearance, TRAP stain positive

A

Hairy cell leukaemia

28
Q

Bone marrow stain positive for Sudan black, myeloperoxidase and non-specific esterase ++

A

Acute monocytic leukaemia (type of AML)

29
Q

Ligamentous laxity, thromboembolic events and short-sightedness suggest which diagnosis?

A

Homocystinuria

30
Q

First line treatment for ITP?

A

HIGH dose steroids

31
Q

Treatment for HELLP syndrome

A

Delivery of baby/placenta

32
Q

Only clotting factor unique to PT

A

Factor VII

33
Q

Leucocytes expressing CD5 when stained (immunophenotyping)

A

CLL

34
Q

Absent CD55 and CD59 on red cell surface

A

Paroxysmal noctural haemoglobinuria (PNH)

35
Q

Haemophilia B is associated with which clotting factor deficiency?

A

Factor IX (9)

36
Q

Translocation t(15;17)

A

Acute promyelocytic leukaemia

37
Q

Pancytopenia and bone marrow biopsy showing increased cellularity

A

Myelodysplasia

38
Q

Translocation of chromosomes 9 and 22

A

Philadelphia chromosome

CML

MRCP (14 decks)

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