MRCP Neurology

Question 1

Poor prognostic factors in GBS

Answer 1

Age > 40
Rapid symptom progression
Preceding diarrhoeal illness
Requiring ventilatory support
High anti-GM1 antibody titres

Question 2

Pathophysiology behind wrist drop

Answer 2

Radial nerve palsy - compression of the radial nerve along the spiral groove

Question 3

Medical treatment of Tourette’s syndrome

Answer 3

Risperidone

Question 4

In genetic inheritance, what does ‘anticipation’ mean?

Answer 4

Symptoms begin at an earlier stage in successive generations

Question 5

Loss of pain & temperature, preservation of joint position and vibration sense.
Increased tone lower limbs.

Answer 5

Syringomyelia

Question 6

Medical management of essential tremor

Answer 6

Propranolol

Topiramate

Question 7

Imaging modality to investigate vestibular schwannoma?

Answer 7

MRI brain (CT not detailed enough)

Question 8

Third nerve palsy, which artery is associated?

Answer 8

Posterior communicating artery (aneurysm)

Question 9

Anti-GQ1B is seen in which condition?

Answer 9

Miller-Fisher syndrome

Question 10

What receptors are involved with myasthenia gravis?

Answer 10

NICOTINIC acetylcholine receptors

Question 11

Which organism meningitis do you give steroids to improve LT outcomes?

Answer 11

Streptococcus pneumoniae

Question 12

Intermittent weakness a few hours after exercise is typical of which condition?

Answer 12

Hypokalaemic periodic paralysis

Question 13

LP showing lymphocytic pleocytosis in someone with slowly progressive motor and sensory symptoms?

Answer 13

Chronic inflammatory demyelinating polyneuropathy

Question 14

EEG findings in herpes simplex encephalitis

Answer 14

Fronto-temporal slowing with periodic sharp wave complexes

Question 15

Diagnostic test for myasthenia gravis

Answer 15

Single fibre EMG

Serology for anti-ACh

Question 16

Increasing confusion and headache, evidence of erythema multiforme.

Answer 16

Herpes simplex encephalitis

Question 17

Target SBP in reduction following acute ICH

Answer 17

140mmHg (with IV labetalol)

Question 18

In what condition is 3,4-diaminopyridine the treatment?

Answer 18

LEMS