Mpox

Question 1

Mpox - organism

Answer 1

Orthopoxvirus

Rodents main reservoir

Question 2

Mpox - epidemiology

Answer 2

Highest burden in West Africa
2 different clades:
-West Africa [Clade 2]
-Central Africa [Clade 1]

Question 3

Mpox - transmission

Answer 3

Person-to-person:
-Direct contact with infectious rash, scabs
-Respiratory secretions during prolonged face-to-face contact
-Transplacental

Question 4

Mpox - diagnosis

Answer 4

Detection of viral DNA by PCR
-Specimen taken from rash

Question 5

Mpox - clinical manifestations

Answer 5

IP - usually 7-14 days [range 5-21 days]

Invasion period: 0-5 days
Fever, headache, fatigue, lymphadenopathy

1-2 days into fever - skin eruption

Question 6

Mpox - treatment

Answer 6

Supportive care, most recover without complication

Tecovirimat [TPOXX]:
-Oral or IV course 14 days

Question 7

Mpox - vaccines

Answer 7

Jynneos/Imvamune/Imvanex [vaccine of choice]
-Live, non-replicating vaccinia virus
-2 doses, 4 weeks apart
-Contraindications: mpox symptoms, egg allergy, ciprofloxacin or gentamicin allergy

ACAM 2000
CI: immune deficiency, cardiac disease, atopic dermatitis