Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

LSHTM > Dengue > Flashcards

Dengue Flashcards

1
Q

Dengue - virus type

A

Arbovirus
4 serotypes
3 structural proteins [capsid, membrane, envelope]
7 non-structural proteins [NS1]

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Dengue - number of cases per year

A

Around 390 million infections/year

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Dengue vectors

A

Aedes agypti and aedes albopictus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Dengue incubation period

A

5-7 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Dengue S+S

A

Fever, headache, retro-orbital pain, myalgia, arthralgia, rash

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Dengue - types of rash

A

Maculopapular rash [first few days of illness]
Petechial rash [day 4-5] on extremeties - coincide with low plt
Recovery rash [‘islands of white’]

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Dengue warning signs [7 total]

A

Abdominal pain and tenderness
Persistent vomiting
Clinical fluid accumulation
Mucosal bleeding
Lethargy, restlessness
Liver enlargement >2cm
Increase in Hct concurrent with rapid decrease in plt count

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Dengue - determinants of disease severity [host factors]

A

Age [severe plasma leakage in children, major bleeding in adults]
Pregnancy
DM, vasculopathies
Pt >60yrs
Over or undernutrition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Dengue - determinants of disease severity [viral factors]

A

Genotype - increased virulence of SE Asian strain of DENV2
Viral load
Non-structural protein 1 [NS1]

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Dengue - determinants of disease severity [host immune response]

A

Secondary infection with heterotypic serotype leading to antibody dependent enhancement [heterotypic, non-neutralising IgG from previous infection bind to dengue virus - enhanced entry of dengue virus into macrophages]

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Dengue - vascular pathogenesis

A

Plasma leak secondary to glycocalyx damage [viral NS1 and endogenous cytokines], loss of endothelial cell integrity [adherens dissociation]

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Dengue - diagnosis

A

1st week of illness:
-Identification of viral RNA using PCR
-Detection of dengue NS1 antigen using ELISA
-Rapid NS1 detection tests
From end of 1st week:
-Serodiagnostic tests = IgM capture ELISA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Dengue - treatment

A

No specific antivirals or adjunctive therapies have shown benefit.
Supportive management

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Dengue - vaccines

A

Dengvaxia [tetravalent live attenuated] = increased severe dengue]
Upcoming TAK-003 [Qdenga]

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Dengue - vector control

A

Elimination of container habitats
Chemical control
Biological control [Wolbachia - intracellular bacterium can reduce dengue viral transmission from Aedes]

How well did you know this?
1
Not at all
2
3
4
5
Perfectly

LSHTM (47 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions