MPGN Flashcards
MPGN is aka
Mesangiocapillary GN
MPGN is associated with infected shunts especially what kind of shunts
Ventriculoatrial shunts (shunt nephritis)
What type of MPGN is most common
Type I
___ when seen on histology, indicate a poor prognosis for MPGN
Crescents
Differentiation between Type I and II MPGN is done via
IF and EM
IF finding in Type I vs Type II MPGN
Type I: C3 and less Ig, Type II: C3 without Ig
EM finding in Type I vs Type II MPGN
Type I: Numerous deposits in the mesangial and subendothelial regions, Type II: Very dense lamina densa in GBM without evident immune complex-type deposits
Occurs when circulating immune complexes become trapped in the glomerular subendothelial space
Type I MPGN
T/F Type II MPGN, like Type I, is mediated by IC deposition
F
Typical lab finding in Type II MPGN
Depressed C3 with normal levels of other complement components
MPGN associated with the presence of C3 nephritic factor
Type II MPGN
Systemic disease associated with Type II MPGN where there is diffuse loss of adipose tissue and decreased complement
Partial lipodistrophy
MPGN is most common in what age group
2nd decade of life
T/F Treatment of causative disease can result in resolution of MPGN
T
Patients with MPGN who have ___ at the time of presentation progress to renal failure more rapidly
Nephrotic syndrome
