Membranous Nephropathy

Question 1

T/F Membranous nephropathy is a common cause of nephrotic syndrome in children

Answer 1

F, rare cause

Question 2

T/F In children, secondary MN is far more common than primary MN

Answer 2

True

Question 3

MC etiologies of secondary MN

Answer 3

1) SLE 2) Chronic infections

Question 4

Best characterized and recognized causes of MN among the chronic infections

Answer 4

1) Hepatitis B 2) Congenital syphilis

Question 5

T/F In MN, removal of offending agent or treatment of the causative disease often leads to resolution of associated nephropathy

Answer 5

T

Question 6

Pathology of MN

Answer 6

Diffuse thickening of GBM WITHOUT significant cell proliferative changes

Question 7

GBM thickening in MN presumably results from

Answer 7

Production of membrane-like material in response to deposition of immune complexes

Question 8

T/F MN is believed to be caused by in situ immune complex formation

Answer 8

T

Question 9

MN is MC at what age group

Answer 9

2nd decade of life

Question 10

MN usually manifests as nephritic vs nephrotic syndrome

Answer 10

Nephrotic syndrome

Question 11

Approximately ___% of children with MN have hypertension at presentation

Answer 11

20%

Question 12

This well known complication of nephrotic syndrome is particularly common in patients with MN

Answer 12

Renal vein thrombosis

Question 13

T/F Diagnosis of MN can only be established by renal biopsy

Answer 13

T

Question 14

___% of children with MN progress to renal failure, ___% continue with active disease, and ___% achieve complete remission

Answer 14

20%, 40%, 40%