Movement Disorders

Question 1

L-Dopa

Answer 1

Most effective for parkinson; Dopamine pre-cursor; coadminister with Carbidopa
Adverse: n/v, hallucinations, compulsive behavior, dyskinesia
End of dose deterioration & on-off phenomenon

Question 2

Proamipexole & Ropinirole

Answer 2

D2 Agonist

Late stage of PD; same side effects as L-Dopa

Question 3

Benzotropine & Diphenhydramine

Answer 3

Anticholinergics (muscarine agonist)
better for tremor & rigidity than bradykinesia
adverse: drowsy, mood change, blurred vision, memory loss
Less effective then L-Dopa and D agonist; for neuroleptic induces Parkinsons

Question 4

Selegiline & Rosagiline

Answer 4

MAO Inhibitors (irreversible inhibitors)
MAO-B responsible for DA metabolism
much safer than MAO-AI (anti-depress)
take with L-Dopa later, neuro-protective

Question 5

Entacapone

Answer 5

COMT inhibitors

restricted to periphery to elevate L-Dopa

Question 6

Amantadine

Answer 6

Anitiviral drug; use limited to 6-8 months
NMDAR inhibition; Increase DA; anticholinergic
early, mild stage of PD

Question 7

Baclofen

Answer 7

Spasmolytic

GABA-B receptor agonist ; MS, ALA, SC Injury

Question 8

Benzodiazepines

Answer 8

GABA-A receptor agonist; relief acute muscle spasm

Question 9

Dantrolene

Answer 9

inhibit ryanodine recepter & diminish Ca release from sarcoplasmic reticulum
IV: malignant hyperthermia & neuroleptic syn.
Oral: MS & cerebral palsy