Epilepsy

Question 1

Carbamazepine

Answer 1

Na Channel blocker
1st line- simple and complex partial, tonic-clonic
trigeminal pain
adverse: aplastic anemia and agranulocytosis diplopia, ataxia

Question 2

Phenytoin

Answer 2

Na Channel Blocker; non sedative
partial and tonic clonic
rapid increase in serum
adverse: ginigival hyperplasia, steven johnson, hurtusism, liver fail

Question 3

Valproic Acid

Answer 3

Na Channel Blocker; T-type Ca channel block
general myclonic
teratogenic, fatal fulminant hepatitis

Question 4

Lamotrigine

Answer 4

Na Channel Blocker:
partial seizure
rashes and steven johnson

Question 5

Phenobarbital

Answer 5

GABA-A enhancer, inhibit Na, Ca and Glutamate
1st line febrile seizures then partial and tonic clonic
induce P450, tolerance, sedation

Question 6

Clonazepam

Answer 6

GABA-A
Benzodiazepine, myoclonic or absence
drowsiness

Question 7

Diazpepam and Lorazepam

Answer 7

BDZ

status epilepticus

Question 8

Tiagabine

Answer 8

Inhibit GABA uptake = adjunct for partial

Question 9

Ethosuximide

Answer 9

T-type Ca Channel blocker
uncomplicated absence
decrease current in thalamus

Question 10

Topiramate

Answer 10

block Na, Ca, & glutamate receptor
partial, tonic-clonic, refractory partial, Lennox-Gastaut
risk: kidney stone, decrease vision, cognition affects

Question 11

Levetiracetam

Answer 11

bind SV2A in vesicle

partial, generalized

Question 12

Gabapentin

Answer 12

partial and tonic clonic

neuropathic pain use

Question 13

Drug Therapy for Status Epilepticus

Answer 13

1) Lorazepam
2) Phenytoin
3) Additional phenytoin
4) Phenobarbital
5) Complete anesthesia