IV Anesthesia

Question 1

Midazolam

Answer 1

BDZ; increase GABA channel opening
premed: sedate, anxiolysis, amnesia
preintubation
minimal CV effects, decrease resp. response to hypercapnea

Question 2

General opioids

Answer 2

Morphine, Fentanyl, Remifentanil, Naloxone

minimial CV effects, decrease resp. drive and increase hypercapnea tolerance

Question 3

Thiopental

Answer 3

Barbituate; prolong GABAr open
decrease BP, increase HR, maintain CO
neuroprotective: decrease ICP, CBF, CMR
long elimination: 8-12 hrs

Question 4

Etomidate

Answer 4

increase GABAr affinity

slight CV increase, minimal resp. effect

Question 5

Propofol

Answer 5

slows channel closing
eliminated in 30-60 min (quick)
CV, Cerebral, and Resp. effects same as others

Question 6

Ketamine

Answer 6

NMDA receptor antagonist
dissociate thalamus from limbic system = dissociative anesthesia
CV: increase BP, HR, CO
mimimal resp. and cause flashbacks, increase ICP

Question 7

Dexmedetomidine

Answer 7

A2 adrenergic agonist, inhibit Adenylate cyclase and NE release
biphasic CV, preserve hypercapnea response
sedative, decrease opioid and anesthetic requirements