Eye drugs

Question 1

Pilocarpine

Answer 1

Glaucoma; muscarinic agonist
increase aq. flow and contract ciliary
problem: X doses, spasm, decrease vision

Question 2

Physostigmine

Answer 2

Glaucoma; AChE inhibitor, works like pilocarpine

can lead to ACh poisoning

Question 3

Timolol

Answer 3

Glaucoma; B adrenergic agonist
inhibit aq. humor production
chronic and open angle
bad for asthma and COPD

Question 4

Epinephrine

Answer 4

Glaucoma; A2 adrenergic agonist

decrease aq. production and improve outflow

Question 5

Dorzolamide

Answer 5

Glaucoma; carbonic anhydrase inhibitor

decrease aq. humor production

Question 6

Latanoprost

Answer 6

Glaucoma; prostaglandin F2a analogue
increase aq. humor outflow
chronic open angle, increase iris pigment

Question 7

Mannitol (IV), Glycerin (oral)

Answer 7

Glaucoma;osmotic agents
decrease aq. humor volume by osmotic pressure
acute glaucoma

Question 8

Pegaptanib

Answer 8

Age-related Macular Degeneration: Anti-VEGF
first RNA optima, high affinity for VEGF
intraocular delivery, once a month

Question 9

Ranibizumab

Answer 9

Age-related Macular Degeneration: Anti-VEGF
monoclonal antibody
slow loss of vision, and improve vision
bind VEGF

Question 10

Bevacizumab

Answer 10

Age-related Macular Degeneration: Anti-VEGF
IV- metastatic CRC and NSC lung cancer
cheaper than Ranibizumab

Question 11

Afilbercept

Answer 11

Age-related Macular Degeneration: Anti-VEGF
chimeric protein, bind VEGF with high affinity
inject every 2 months