Movement Disorders

Question 1

What is the purpose of PD treatment?

Answer 1

doesn slow

helps with motor symptoms

Loss of dopamine

Question 2

What are the 4 major classes of PD treatment

Answer 2

Question 3

describe Dopamine replacemetn therapy mechanism of action- Levodopa

Answer 3

Levodopa

Precurosr to dopamine- converted to Dopamine in neuroens by AADC

Question 4

Describe the mechanims of action of dopamine agonists?

Answer 4

D2 like receptor agonost actitivy produces the symptomatic antiparkinsonian effect

(more active on some subtypes than others)

Question 5

Describe the Mechanims of action of COMT inhibitiors

Answer 5

Catechol-O-methyltransferase (COMT) inhbition

reduce metabolism of Leocdopa- extending its plasam half life

Question 6

Describe the mechanism of acrtion of MOA- B inhbition

Answer 6

MOA-B inhbittion (monomaine oxidase isoenyzme type B

prveent sbreakdown of dopmamine

more dopamine available

Selegiline

Question 7

what is a major side effect seen after 5-10 years of Levodopa use?

Answer 7

Levodopa- induced dyskinesia

Question 8

describe deep brain stimulation therapy in PD?

Answer 8

provide stimulation to STN, globus palliodus intern and subthalamic nucleus- imprve symptoms

Question 9

What are the 3 main funbctional roles of the corticao-basal ganglia connection?

Answer 9

Motor cicuit

associative circuti and limbic circuit

Question 10

PD and HD which is akinetic and which is hyperkinetic disoprder

Answer 10

PD- akinetic (rigid disroder)

HD_ hyperkinetic