Movement 2 Flashcards

1
Q

Cerebellum is the brain region that is responsible for…

A
  • Basic coordination of limbs
  • Eye movement
  • Balance
  • Muscle tone
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2
Q

Three functional components of the cerebellum

A
  • Vermis & Anterior Lobe
  • Posterior Lobe
  • Flocculonodular lobe
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3
Q

Major inputs of signal into the cerebellum are from the ____ and ____ ____, which relay in ____ ____

A

Motor; promotor cortex; pontine nuclei

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4
Q

3 Layers of cerebellar cortex

A
  • Molecular layer
  • Purkinje cell layer
  • Granular layer
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5
Q

The molecular layer of the cerebellar cortex includes…

A

Dendrites of purkinje cells; interneurons

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6
Q

Purkinje cells have their dendrites in…
(They receive more ____ ____ than any other neuron)

A

—>molecular layer
(Synaptic inputs)

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7
Q

Granule cells are located in the ____ ____, and they have very ____ dendrites. They also respond to the neurotransmitter____, which has an excitatory effect on the cell

A

Granule layer; short (or few); glutamate

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8
Q

Parallel fibers are…

A

Granule cell axons that project to the molecular layer; they split into two branches running in opposite directions

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9
Q

2 external inputs to the cerebellar cortex are ___ and ____, both are ___rgic

A

Climbing fibers; Mossy fibers; Glutamate

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10
Q

Climbing fibers

A
  • From Inferior Olive (brainstem)
  • Synapse on Purkinje cell dendrites (contact ~1–10 of them)
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11
Q

Mossy fibers

A
  • From Pontine nuclei (brainstem)
  • Full pathway: “corticopontocerebellar”
    (Cerebral cortex —> pontine nucleus —> cerebellum)
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12
Q

Primary output from the cerebellar cortex is done by ____ cells

A

Purkinje

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13
Q

Anatomical loop of the brain

A
  1. Cerebral cortex
  2. Pontine nucleus
  3. Cerebellum
  4. Deep cerebellar nuclei
  5. Thalamus
  6. Back to the top
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14
Q

Cerebellum damage can lead to the inability to ____ movement accordingly to ____ ____

A

Adjust; Sensory information

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15
Q

Common behavioral traits following cerebellum damage

A
  • Balance/gait
  • Guided movements
  • Error in range and force of movement
  • Inability to rapidly stop the limb
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16
Q

Group of interconnected sub cortical brain structures of the basal ganglia

A
  • Caudate
  • Putamen
  • Globus pallidus
  • Thalamus
  • And more that we’re uninterested in
17
Q

The ventral regimental area of basal ganglia is associated with which neurotransmitter?

A

Dopamine

18
Q

The ____ and ____ in primates are separate, while in rodents they are combined into a single structure called the ____

A

Caudate; Putamen; Striatum

19
Q

Projections from Cortex to Striatum in the basal ganglia

A
  • Pyramidal tract (PT)
  • Intertelencephalic (IT)
20
Q

Pyramidal tract neurons

A

Upper motor neurons that project to brainstem and spinal cord

21
Q

Intertelencephalic neurons

A

Motor cortex neurons that do NOT project to brainstem and spinal cord

22
Q

Direct pathway in the basal ganglia send axons to…

A
  • Globus Pallidus internal segment (GPi)
  • Substantia Nigra pars reticulata (SNR)
23
Q

Indirect pathway neurons of the basal ganglia send axons to…

A
  • Globus Pallidus external segment (GPe)
    (projects to the subthalamic nucleus (STN), which then send axons to GPi & SNR)
24
Q

GPi and SNR send axons to the ____, which then projects back to the ____ ____

A

Thalamus; cerebral cortex

25
Q

Excitation of neuron is done by ____ while inhibition is by ____

A

Glutamate; GABA

26
Q

The activity of the glutamate neuron has a ____ relationship with the output in the postsynaptic neuron

A

Direct

27
Q

The activity of the GABA neuron has a ____ relationship with the output in the postsynaptic neuron

A

Reversed

28
Q

Increase in direct pathway activity will result in ____ locomotion

A

More

29
Q

Increase in indirect pathway activity will result in ____ locomotion

A

Less

30
Q

SN compacta Dopamine: D1 for ____ pathway, D2 for ____ pathway

A

Direct; Indirect