Motor neurone disease Flashcards
1
Q
what are the 4 classification types of ALS?
A
spinal ALS (classic MND)
bulbar ALS (early tongue and bulbar involvement)
progressive muscular atrophy (only LMN)
primary lateral sclerosis (only UMN)
2
Q
what genes are associated with familial MND?
A
SOD1
FUS
C90RFT72
3
Q
what is the average age of onset of MND?
A
50-60yrs in sporadic cases
4
Q
how is MND managed?
A
Riluzole medication
supportive;
- drooling: anticholinergics
- PEG/NG tube
- Spasticity: Baclofen or botox injections
- pain: simple analgesia
5
Q
what are the features of MND?
A
mixed clinical picture of both UMN and LMN signs
no sensory disturbance
eye and sphincter muscles spared until late disease
