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Block 3 JM version > Morphology of Erythryopoiesis > Flashcards

Morphology of Erythryopoiesis Flashcards

1
Q

Totipotent stem cells

A

Can turn into anything

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2
Q

Pluripotent stem cells turn into?

A

Turns into any cell besides foetal cells.

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3
Q

Multipotent stem cells

A

Committed to self-renewal of limited tissue cells.

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4
Q

Multipotent stem cell commits to the?

A

Erythryoid program (becoming an erythroid progenitor cell)

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5
Q

Burst forming unit-erythryoid (BFU-E) turns into?

A

Colony forming unit-erythryoid (CFU-E)

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6
Q

Erythryoid precursor

A

This is the expression of the erythroid program which occurs several divisions later. Erythroid precursor is morphogenically distinguishable

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7
Q

Earliest erythryoid cell is?

A

Proerythryoblast

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8
Q

Proerythryoblast is identified by the?

A

Identified by the accumulation of erythryoid specific proteins and decreased nuclear activity.

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9
Q

List stages of development of mature red blood cells

A
  1. Proerythryoblast
  2. Basophilic erythryoblast
  3. Polychromatic erythryoblast
  4. Pyknotic erythryoblast
  5. Reticulocyte
  6. Mature red blood cell
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10
Q

Splenic macrophages removes?

A

Removes the nucleus of proerythryoblast.

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11
Q

Reticulocyte is?

A

Brand new red cell

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12
Q

Reticulocyte is formed when?

A

Splenic macrophages removes the nucleus of proerythryoblast

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13
Q

Reticulocytes have no?

A

Have no central pallor as seen in mature RBCs

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14
Q

How long until deficiencies are recognized when reticulocytes enter blood circulation?

A

6-9 days

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15
Q

Bone marrow proliferation maturation takes?

A

3-5 days

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16
Q

Reticulocyte maturation and entry takes how long?

A

3-4 days

17
Q

Meaning of seeing reticulocytes in blood?

A

The person is anaemic because imature cells are being pushed out.

18
Q

RBC production occurs in liver and spleen?

A

RBC production occurs in liver and spleen for the first 7-30 weeks.

19
Q

After birth, RBC production occurs in?

A

Long bones

20
Q

Erythryoid prcursor cell compartment contains?

A

Contains mitochondria which drive haemoglobin synthesis

21
Q

Mitochondria in erythryoid precursor cell is needed for?

A

Driving haemoglobin synthesis

22
Q

Abnormalities in erythryoid precursor cell’s mitochondria is called?

A

Porphyria

23
Q

Different abnormalities in haemoglobin synthesis cause?

A

Causes build up of precursor cells and can cause nerve damage or skin problems.

24
Q

Haem inhibits _____ and reduces _____.

A

Inhibits ALA-S production and reducees iron pool.

Block 3 JM version (13 decks)

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