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Liz's Hematology Module 2 > Morphology in Mature Lymphoid Disorders > Flashcards

Morphology in Mature Lymphoid Disorders Flashcards

1
Q

What lymphoproliferative disorder is associated w/ this cell?

A

Hairy Cell Leukemia

  • Oval or indented nucleus w/ abundant cytoplasm
  • May have single nucleolus
  • Cytoplasm is irregular and gray-blue w/ delicate hair-like cytoplasmic projections
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2
Q

What cell line is CLL/SLL?

A

B-cell

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3
Q

Describe the clinical presentation of Hairy Cell Leukemia

A
  • Pancytopenia
  • Severely enlarged spleen
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4
Q

The STAT3 gene mutation occurs in which lymphoproliferative disorder?

A

Large Granular Lymphocyte Leukemia

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5
Q

Burkitt Lymphoma “always” involves the ____ ____ but ____ ____ may also be infiltrated

A

Lymph Nodes; bone marrow

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6
Q

What abnormalities indicates a poor prognosis in patients w/ CLL?

A
  • del(11)(q22-23) or del(11) + 12
  • Rapid lymphocyte doubling time (< 12 months)
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7
Q

Describe the clinical presentation of Mycosis Fungoides and Sezary Syndrome

A
  • Neoplasic proliferation of T cells in the skin → itchy, painful rash (pruritus)
  • Circular patterns of baldness, inflammation of hair follicles
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8
Q

Which lymphoproliferative disorder is known to be often present in localized LN involvement

A

Classical Hodgkin Lymphoma

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9
Q

What lymphoproliferative disorder is associated w/ this cell?

A

Mycosis Fungoides and Sezary Syndrome

  • Convoluted and cerebriform nucleus
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10
Q

Which lymphoproliferative disorder is know for a diffuse architecture w/ starry sky pattern?

A

Burkitt Lymphoma

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11
Q

Which lymphoproliferative disorder is known to be Cyclin D1+ ?

A

Mantle Cell Lymphoma

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12
Q

Which lymphoproliferative disorder is known for containing smudge cells?

A

CLL

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13
Q

What is Waldenstrom’s Macroglobulinemia?

A

Malignant lymphoproliferative disorder involving plasma cells (B-cell lineage) that produce monoclonal IgM

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14
Q

Which lymphoproliferative disorder is known to be CD7- and CD8-?

A

Cutaneous T-cell Lymphoma/Mycosis Fungoides

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15
Q

What is the age of onset for Large Granular Lymphocyte Leukemia?

A

Predominantly 45-75 years old

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16
Q

Predominant cell type found in LN paracortex

A

T cells

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17
Q

Which lymphoproliferative disorder is known to have CD11c, CD103+, Cd123+, bright CD20+ immunophenotype?

A

Hairy Cell Leukemia

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18
Q

Which lymphoproliferative disorder is known to be CD45-?

A

Classical Hodgkin Lymphoma

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19
Q

The t(14;18) abnormality is found in which lymphoproliferative disorder?

A

Follicular Lymphoma

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20
Q

Which lymphoproliferative disorder is know for diffuse infiltrates into the skin?

A

Cutaneous T-cell Lymphoma/Mycosis Fungoides

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21
Q

100% proliferation via the Ki67 stain is used w/ which lymphoproliferative disorders?

A

Burkitt Lymphoma

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22
Q

Which lymphoproliferative disorder is know to be bcl2+ ?

A

Follicular Lymphoma

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23
Q

What are the three types of Burkitt Lymphoma?

A
  1. Endemic 2. Sporadic 3. Immunodeficiency-associated
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24
Q

What is the lineage of plasma cells?

A

B-cell line

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25
Q

Diagnostic features of Waldenstrom’s Macroglobulinemia

A
  • Hyperviscosity of blood → blurry vision, headache, vertigo, tinnitus, heart failure
  • Anemia
  • Cryoglobulinemic purpura (“purple rash”) due to hyperviscosity and IgM
  • Severe clotting disorders
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26
Q

What is the age of onset for CLL/SLL?

A

Median age: 65-70 years old; rare in patients < 30 years old

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27
Q

What cell line is Large granular lymphocyte Leukemia?

A

T-cell

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28
Q

What lymphoproliferative disorder is associated w/ this cell?

A

Plasma Cell Myeloma

  • Rouleaux of RBCs on peripheral blood due to paraproteins
  • Plasma cells → eccentric nucleus, deeply basophilic cytoplasm, perinuclear clear zone (hof)
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29
Q

What Ig do mott cells produce?

A

IgG

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30
Q

What is the age of onset for Burkitt Lymphoma?

A

Median age: 30 years old and mainly children

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31
Q

What is the age of onset for Hairy Cell Leukemia?

A

Median age: 50 years old

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32
Q

Diagnostic features of Plasma Cell Myeloma

A

Punched out bone lesions seen on radiograph

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33
Q

What lymphoproliferative disorder is associated w/ this cell?

A

Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia

  • Lymphs are mostly mature, monotonous, and have round nuclei w/ clumped chromatin
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34
Q

What cell line is Follicular Lymphoma?

35
Q

What is the significance of the Ki67 stain?

A

Indicates rapid proliferation

36
Q

Which lymphoproliferative disorder is known to have sezary cells in the PB?

A

Cutaneous T-cell Lymphoma/Mycosis Fungoides

37
Q

Which type of Hodgkin Lymphoma is associated w/ the Epstein Barr virus and HIV immunosupression?

A

Classical Hodgkin Lymphoma

38
Q

What is the immunophenotyping for Waldenstrom’s Macroglobulinemia?

A

CD19+, CD20+, CD24+, Kappa/Lambda light chains

39
Q

Sporadic type of Burkitt Lymphoma

  • Age of onset
  • Geographic location
  • Immunodeficiency status
A
  • Age of onset: median age of 35 years old
  • Geographic location: U.S. and Europe
  • Immunodeficiency status: < 1% of non-Hodgkin lymphomas
40
Q

What cell line is Hariy Cell Leukemia?

41
Q

What are each of the inclusions called in a mott/grape cell/morula?

A

Russell bodies

42
Q

The BRAF-V600E mutation is found in which lymphoproliferative disorder?

A

Hairy Cell Leukemia

43
Q

What lymphoproliferative disorder is associated w/ this cell?

A

Prolymphotcytic Leukemia

  • Relatively large cells w/ one prominent nucleolus which appears to be “punched out”
  • Intermediate chromatin condensation
44
Q

What are the two types of cells found in Plasma Cell Myeloma?

A
  • Flame cells
  • Mott cells
45
Q

Immunodeficiency-associated type of Burkitt Lymphoma is associated with…

46
Q

What Ig do flame cells produce?

47
Q

What is the site of presentation for CLL?

A

Bone marrow

48
Q

What are the two types of Hodgkin Lymphoma?

A
  1. Classical Hodgkin Lymphoma
  2. Nodular Lymphocyte Predominate Hodgkin Lymphoma
49
Q

What cell line is Mycosis Fungoides?

50
Q

Treatment options for Waldenstrom’s Macroglobulinemia

A
  • Alkylating chemotherapeutic agents
  • Rituximab (monoclonal Ab against CD20)
  • IgM removed via plasmaphoresis for rapid (and temporary) improvement of symptoms
51
Q

Which lymphoproliferative disorder is the most common extranodal lymphoma?

A

Cutaneous T-cell Lymphoma/Mycoides Fungoides

52
Q

What is the age of onset for Mycosis Fungoides?

53
Q

What lymphoproliferative disorder is associated w/ this cell?

A

Burkitt Lymphoma

  • Accumulation of monotnous medium-sized mature B-cells w/ many vacuoles
54
Q

Predominant cell type found in LN medulla

A

Plasma cells

55
Q

The t(11;14) abnormality is found in which lymphoproliferative disorder?

A

Mantle Cell Lymphoma

56
Q

What cell line is Classical Hodgkin Lymphoma?

57
Q

Which lymphoproliferative disorder is known for containing hairy cells?

A

Hairy Cell Leukemia

58
Q

Monoclonal IgG or IgA in serum or urine, rouleaux, and bone lesions are found in which lymphoproliferative disorder?

A

Plasma Cell Myeloma/Multiple Myeloma

59
Q

In CLL, what B-cell abnormality is found in the peripheral blood?

A

> 5 × 109/L B-cells sustained for 3 months

60
Q

What cell line is Plasma Cell Myeloma/Multiple Myeloma?

61
Q

Which lymphoproliferative disorder is know to have medium sized cells w/ many vacuoles?

A

Burkitt Lymphoma

62
Q

What cell line is Burkitt Lymphoma?

63
Q

What genetic abnormality indicates a good prognosis in patients w/ CLL?

A

del(13)(q14.3)

64
Q

Endemic type of Burkitt Lymphoma

  • Age of onset
  • Geographic location
  • Immunodeficiency status
A
  • Age of onset: Peak incidence b/w 4-7 years old
  • Geographic location: Equatorial Africa
  • Immunodeficiency status: 50x higher incidence than U.S.
65
Q

What is the age of onset for Follicular Lymphoma?

A

Median age: 60 years old

66
Q

What was the historic cytochemical stain that was used to confirm the presence of hairy cells?

67
Q

What are smudge cells?

A

Broken up B-cells

68
Q

The t(8;14) and MYC oncogene is found in which lymphorproliferative disorder?

A

Burkitt Lymphoma

69
Q

Which lymphoproliferative disorder is known to have Reed-Sternberg and Hodgkin cells?

A

Classical Hodgkin Lymphoma

70
Q

What lymphoproliferative disorder is associated w/ this cell?

A

Plasma Cell Myeloma

  • Rouleaux of RBCs on peripheral blood due to paraproteins
  • Plasma cells → eccentric nucleus, deeply basophilic cytoplasm, perinuclear clear zone (hof)
71
Q

What is the age of onset for Mantle Cell Leukemia?

A

Median age: 60 years old

72
Q

Predominant cell type found in LN follicles

73
Q

T/F, SLL often demonstrates cytopenias

A

False, CLL does

  • There are no cytopenias in SLL b/c there is no BM infiltration
74
Q

In SLL, what B-cell abnormality is seen in the peripheral blood?

A

< 5.0 × 109/L B-cells

75
Q

What lymphoproliferative disorder is associated w/ this cell?

A

Hodgkin Lymphoma

  • Reed-Sternberg cells found in low numbers in the LNs in a reactive background
76
Q

Which lymphoproliferative disorder is known to be CD4-, CD8+, CD57+, CD16+, TIA1+, and have Granzyme B?

A

Large Granular Lymphocyte Leukemia

77
Q

What cell line is Mantle Cell Lymphoma?

78
Q

Describe the clinical presentation of Prolymphocytic Leukemia

A
  • Absolute lymphocytosis (> 100 × 109/L)
  • Anemia
  • Thrombocytopenia
  • B or T cell
79
Q

Which lymphoproliferative disorder is know for plasma cell infiltrates in the BM w/ >30% of cellularity?

A

Plasma Cell Myeloma/Multiple Myeloma

80
Q

Which lymphoproliferative disorder is the most common non-Hodgkin?

A

Follicular Lymphoma

81
Q

____ changes and ____ changes are caused by ____ and ____ changes

A

Morphologic; Functional; Genetic; Epigenetic

82
Q

What is the site of presentation for SLL?

A

Lymph node

83
Q

The cortex of a normal LN consists of…

A

Contains the follicles/germinal centers

Liz's Hematology Module 2 (13 decks)

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