Mood stabilizers & antipsychotics

Question 1

What is Valproic Acid (Depakote)?

Answer 1

• Anticonvulsant

- Effective in acute phase of mania (bipolar)

Question 2

What labs do you check before starting Valproic acid?

Answer 2

• liver function
• blood counds
• pregnancy test

Question 3

What is Lamotrigine used for?

Answer 3

-depressed phase (bipolar)

**not appropriate for mania

Question 4

What is Lamotrigine used for?

Answer 4

-depressed phase (bipolar)

**not appropriate for mania

Question 5

What is the scary side effect of Lamotrigine?

Answer 5

Stevens-Johnson syndrome

Question 6

What is Carbamazepine used to treat?

Answer 6

Prevents mania

Question 7

Cabamazepine induces hepatic enzymes, _________ its own metabolism and the metabolism of other drugs over a about a two week period.

Answer 7

increasing

*oxcarbamaepine does not induce hepatic enzymes

Question 8

What is haloperidol?

Answer 8

A high potency antipsychotic

Question 9

What is chlorpromazine?

Answer 9

A low potency antipsychotic

Question 10

What is chlorpromazine?

Answer 10

A low potency antipsychotic

Question 11

What makes an antipsychotic atypical?

Answer 11

• Shorter binding time at D2 receptor

- 5HT2A antagonism

Question 12

Why are atypical antipsychotics associated with less sensitizing of the striatal dopamine receptor systems, and thus less tardive dyskensia?

Answer 12

Shorter binding periods to D2 receptors