Mood Stabilizers

Question 1

Lithium

Answer 1

Reduces suicide attempts and completions; inhibits inositol monophosphate and second messengers

Question 2

Drug interactions of Lithium

Answer 2

NSAIDS, Thiazide diuretics. Ebstein’s anomaly of tricuspid valve in first trimester.

Question 3

Discuss Valproic Acid

Answer 3

Increases GABA by inhibit degradation and stimulating synthesis/release.
Causes NTDs in pregnancy

Question 4

Discuss Carbamazepine

Answer 4

Anticonvulsant; Blocks Na channels, Potent CYP450 inducer reducing antipsychotic effectiveness. Causes NTDs and facial defects

Question 5

Discuss Lamotrigine

Answer 5

Prevents depressive episodes of bipolar disorder by blocking Na channels. Can cause Steven Johnson’s syndrome and TEN