Mood Disorders Flashcards

1
Q

why is there a decrease in depression in older patients

A

under-reporting

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2
Q

what is euthymia

A

normal mood

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3
Q

what is hyperthymia

A

elevated mood

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4
Q

what is cyclothymia

A

varied mood

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5
Q

what is dysthymia

A

persistent low mood

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6
Q

what is anhedonia

A

loss of enjoyment/pleasure

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7
Q

what is anergia

A

loss of energy

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8
Q

whast is stupor

A

absence of relational functions like action and speech

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9
Q

what is psychomotor retardation

A

subjective/objective slowing of thoughts/movement

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10
Q

MSE depression - appearance/behaviour?

A

reduced facial expression
furrowing of brows
reduced eye contact and gesturing
hard to establish rapport

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11
Q

MSE depression - mood?

A

associated with what pt describes

low, down, miserable, unhappy, sad, empty, black, numb

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12
Q

MSE depression - affect?

A

depressed, limited reactivity, emotional paralysis

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13
Q

MSE depression - thought?

A
usually normal form 
flow may be slowed or absent 
may have delusion in content 
guilt, nihilism, hypochondriasis, poverty 
suicidal 
cotards syndrome
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14
Q

MSE depression - perception?

A

may have increased self referential thinking - people talking aobut them
hallucinations possible - 2nd person and derogatary

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15
Q

MSE depression - cognition?

A

slowed, often poor memory

pseudo-dementia

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16
Q

MSE depression - insight?

A

insight almost always preserved and aware of symptoms

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17
Q

MSE depression - speech?

A

reduced rate, pitch, intonation, volume

limited content

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18
Q

general criteria (not core) for the patient to meet a depression diagnosis

A

no evidence of mania
>2wks
must be clearly abnormal and severely impact function

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19
Q

core features of depression

A

at least 2/3
low mood and present almost every day for at least 2 weeks
low energy
loss of interest or pleasure in activities

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20
Q

additional features of depression

A
need at least 4 
loss of confidence/self esteem 
feelings of guilt 
wishing to die 
difficulty in concentration 
change in psychomotor activity, either subjective/objective agitation/retardation 
sleep disturbance 
change in appetite
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21
Q

grading of severity of depression

A

moderate - 2 core symptoms and 4 others to give 6

severe - all 3 and 5 others to give 8

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22
Q

features fo psychotic depression

A

paranoid, mood congruent or hypochondriacal

cotards syndrome

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23
Q

what is cotards syndrome

A

nihilistic delusion in which the patient belives they are not alive or do not exist

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24
Q

what is disruptive mood dysregulation disorder

A

alterantive to bipolar disorder in children 6-18 and cannot be better explained by another disorder

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25
Q

criteria for DMDD

A
Severe recurrent temper outbursts
inconsistent with developmental level 
>3x per week 
persistently angry most of the day and nearly every day 
present more than >1yr with relief >3m
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26
Q

what is bipolar I

A

current or past episode of mania

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27
Q

what is bipolar II

A

current/past hypomanic episode with current/pasdt depressive episode

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28
Q

what is bipolar III

A

hypomanic episode following antidepressants

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29
Q

what is bipolar affective disorder

A

two or more episodes where mood/activity levels are significantly disturbed
mania, hypomania or depression

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30
Q

distinguishing depression from bipolar

A

single episode mania/hypomania before depression is highly likely bipolar
first episode mania/hypomania on background of recurrent depression means it is bipolar and no longer depression

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31
Q

criteria for hypomanic episode

A
present 4 consecutive days 
>/= 3 of the following 
increased activity/restless
increased talkativeness 
difficulty concentrating 
decreased need for sleep 
increased libido 
mild spending spree/reckless and irresponsbile behaviour
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32
Q

criteria for manic episode

A
elevated/irritable mood and definitely abnormal
at least 1 week unless needs admitted 
>/=3 of 
increased activity/restless
talkativeness
flight of ideas 
loss normal social inhibition 
decreased need for sleep 
grandiosity/inflated self esteem
distractible 
reckless behaviour 
marked increase sexual energy
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33
Q

typical onset bipolar

A

20s

FHx implies lower sge onset

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34
Q

how much of the time are bipolar pts symptomatic

A

50%

1/3 manic 2/3 depressed

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35
Q

poor outcomes BAD?

A
early onset 
poor SE status 
multiple comorbidity 
FHx 
rapid mood flux 
mixed presentation 
psychosis
36
Q

true/false - genetic influence over mood disorders are polygenic

A

true

37
Q

brain regions implicated in mood disorders?

A
orbitofrontal cortex 
ventromedial frontal cortex
dorsolateral prefrontal cortex
hippocampus 
amygdala 
anterior cingulate cortex
38
Q

cognitive deficits associated with depression?

A

poor attention
slow memory
slow reaction time
impaired planning

39
Q

functions of the hippocampus

A

learning, cognition, HPA axis
connection to amygdala for emotion and fear
connection to prefrontal cortex for memory, cognition and mood

40
Q

what parts of the brain are responsible for approaching and seeking behaviours and what is the principle neurotransmitter?

A
mesolimbic and cortical projections 
ventral and dorsal striatum 
amygdala 
anterior cingulate 
orbitofrontal cortex 
dopamine
41
Q

what parts of the brain are responsible for defence and survival behaviours and what is the principle neurotransmitter?

A
central nucleus of amygdala 
hippocampus 
ventroanterior and medial hypothalamus 
periaqueductal grey matter 
5-HT
42
Q

ways of mood monitoring

A

IDS-30-SR
QIDS
MADRS
mood diary

43
Q

what is MADRS good for?

A

profound depression with little to no engagement

44
Q

how to chose AD?

A

go for fewest side effect profiules first
if person responds to drug or class stick with it
match side effects to symptoms

45
Q

top 4 ADs

A

escitalopram
sertraline
mirtazapine
venlafaxine

46
Q

what SSRI has a good cardiac safety profile

A

sertraline

47
Q

what size effects does mirtazapine have and what side effects is it more protective of

A

promotes sleep and weight gain

less likely to cause nausea and sexual side effects

48
Q

what choices to make if an AD isnt working?

A
check congruence 
increase dose 
swap medicine 
combine - often SSRI/SNRI and mirtazapine 
augment with Li or antipsychotic
49
Q

how long to keep on AD for depression?

A

6m for first episode

1-2yrs for 2nd episode

50
Q

management of acute mania/hypomania

A
stop AD 
max antimanic dose 
admit if manic 
antipsychotic - olanzapine, quetiapine, risperdone 
OR Li, valproate, ECT, carbamazepine 
may need IM 
BZD may be indicated fo symptom control
51
Q

management of acute bipolar depression

A

AD ONLY if with antimanic - valproate, Li or antipsychotic
SSRI - fluoxetine preferred
quetiapine, olanzapine, lurasidone

52
Q

maintenance management of bipolar disorder

A

Li gold standard
can give antipsychotics, lamotrigine (depressive), valproate (manic/hypomanic)
psychoeducation

53
Q

discuss monitoring of lithium?

A

serum Li, U&E, ECG, TFT, Ca, weekly then move to every 3-6m

54
Q

true/false - in a pt woith hypothyroidism secondary to lithium you should discontinue Li

A

false - start levothyroxine

55
Q

what may happen if an AD is given on its own to a pt with bipolar

A

it can precipitate a manic episode

56
Q

what may an SSRI cause in the elderly?

A

hyponatraemia

57
Q

administration of ECT?

A

2x weekly and usually inpatient
general anaesthetic with muscle relaxant
dose of electricity titrated to give seizure 15-30s
seizure monitored with EEG and can be ceased with BZD

58
Q

what gen anaesthetic is given for ECT and why can that pose an issue

A

propofol

can raise seizure threshold

59
Q

what is needed to give ECT without consent

A

2nd independent dr opinion, unless in an emergency

60
Q

physical side effects of ECT?

A
headache 
temp cognitive issues 
memory problems 
muscle ache 
confusion 
nausea 
cerebrovascular 
anaesthetic 
cardiovascular 
prolonged seizure
61
Q

examples of psychological therapies

A
CBT
behavioural activation 
CBASP 
acceptance and commitment therapy 
psychoeducation
62
Q

what is personality and what are the 5 factors of persoanlity

A
relatively predictable patterns of thinking, feeling and behaving, consistent across time space and context 
openness 
conscientiousness 
extraversion
agreeableness 
neuroticism
63
Q

what is a disorder of personality

A

individual and characteristic pattern of experience deviating from culturally expected and accepted range
pervasive, inflexible, distress and cannot be explained vt any other mental disorder

64
Q

rating scales for persoanlity disorder

A
ZAN-BPD
PAS
PDQ-4
MMPI
BDQ
IPDE
65
Q

diagnostic features of paranoid PD

A

> /= 4
excess sensitivity to setback
tendency to bear grudge
suspiciousness or misconstrued perception of friendly activity
tenacious sense of personal rights
recurrent suspicions of partners sexual fidelity
persistent self referential attitude
preoccupation with unsubstantiated conspiratorial events of world at large

66
Q

diagnostic features of schizoid PD

A
>/= 4
little/no activities give pleasure 
flat affect or emotional coldness 
struggle/unable to show warm feelings 
little interest in sexual experiences with others 
solitary activities 
indifferent to praise/critisism 
excess preoccupation with fantasy/introspection 
insensitive to prevailing social norms
67
Q

diagnostic features of schizotypal PD

A
>/= 5
ideas of reference 
odd thinking, magical thinking 
unusual perceptual experiences 
odd thinking/speech 
suspicious/paranoid ideation 
inappropriate/constricted affect 
odd, eccentric or peculiar behaviour 
lack of close friends or confidants 
excess social anxiety, associated with paranoia and not diminishing with familiarity
68
Q

diagnostic features of dissocial PD

A

> /= 3
unconcern for feelings of others
irresponsible and disregard for social norms
low tolerance to frustration, aggression and violence
incapacity to experience guilt, or to profit from adverse experience
proneness to blame others

69
Q

diagnostic features of impulsive EUPD

A

> /= 3
acting unexpectedly without considering consequences
quarrelsome and conflicts with others
outburst of action/violence
difficulty maintaining course that offers no immediate reward
unstable mood

70
Q

diagnostic features of borderline EUPD

A
>/= 2 impulsive and >/= further of 
disturbed, uncertain self image 
intense and unstable relationships 
excess effort to avoid abandonment 
chronic emptiness 
recurrent threats or acts of self harm
71
Q

diagnostic features of histrionic PD

A

> /= 4
self dramatisation and theatricality
suggestible
shallow, labile affect
seeking activities where subject is feature of attention
inappropriately seductive in appearance/behaviour
overly concerned with physical attractiveness

72
Q

diagnostic features of anxious PD

A

> /= 4
pervasive feelings of tension/apprehension
belief oneself is inferior to others
excess preoccupation about criticism/rejection in social situation
unwilling to get involved unless certain of being liked
restricted lifestyle
avoidance of activities that have significant interpersonal contact due to rejection, disapproval

73
Q

diagnostic features of dependent PD

A

> /= 4
encouraging/allowing others to make their important life decision
subordination of ones own needs to those of other on whom they are dependent
unwilling to make reasonable demands on one depends on
feeling uncomfortable/helpless when alone
preoccupation with fears of being left to take care of themselves
limited capacity to make everyday decisions without excessive advice or reassurance

74
Q

diagnostic features of anankastic PD

A

> /= 4
excess doubt/caution
preoccupied with details, rules, list, order
perfectionism
excess conscientiousness
rigid/stubborn
excess adherence to social convention
undue preoccupation with productivity leading to exclusion of pleasure and relationships
unreasonable insistence that others submit to their way of doing things

75
Q

diagnostic features of narcissistic PD

A

> /= 5
grandiose self importance
fantasies of infinite success, control or brilliance
belief they are extraordinary or belief they can only be understood by others of same
desire for unwarranted admiration
sense of entitlement
interpersonal oppressive behaviour
resentment of others who are resentful of them
egotistical behaviour/attitude

76
Q

when may low dose antipsychotic be good for PD? what type?

A

can help paranoid BPD
reduce suspiciousness in schizoid, paranoid or schizotypal
haloperidol, quetiapine, olanzapine

77
Q

when may AD be of benefit in PD

A

dissocial, emotionally unstable, histrionic and narcissistic mood difficulty
reduce anxiety in anankastic, avoidant and dependent

78
Q

when may mood stablisers be of use in PD

A

lamotrigine

mood and impulsivity in EUPD and BPD

79
Q

first and second line therapies for impulse control

A

first - SSRI

2nd - olanzapine, valproate, carbamazepine, low dose antipsychotic

80
Q

first, second, third line therapies for affective dysregulation

A

1st - SSRI/mirtazapine
2nd - alternative SSRI/mirtazapine
3rd - low dose antipsychotic, valproate, carbamazepine, olanzapine

81
Q

therapies for cognitive perceptual symptoms

A

low dose antipsychotic

82
Q

pharmacological mx of interpersonal difficulties

A

none, it would be inappropriate

83
Q

management of dissocial PD

A

group based psychological therapies

84
Q

psychological therapies for EUPD

A

dialectal behavioural therapy
mentilisation based therapy
STEPPS

85
Q

when to admit for EUPD

A

acute increase suicidal risk
use carefully as can cause harm
crisis plan

86
Q

pharmacological therapies for EUPD

A

lamotrigine
topiramate
AD if needed
antipsychotics