Dementia Flashcards

1
Q

what is the yerkes-dodson curve

A

low anxiety have poor arousal/performance
moderate stress and anxiety have correlation to good arousal and persormance
high levels of anxiety impair performance significantly

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2
Q

how long does the short term memory last

A

<1min

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3
Q

what is the implicit long term memory

A

unconscious memory leading to procedural memory

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4
Q

what is the explicit long term memory

A

conscious memory split into semantic and episodic

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5
Q

4 stages of memory processign

A

attention
encoding
storage
retrieval

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6
Q

what is anterograde memory loss

A

difficulty acquiring new material and remembering since injury/disease

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7
Q

what is retrograde memory loss

A

difficulty remembering info prior to onset of illness/injury

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8
Q

true/false - dementia leads to clouding of consciousness

A

FALSE!!

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9
Q

questions to ask patients with memory loss

A
does this affect day to day functioning?
any kitchen issues?
follow the news?
use appliances?
recent accidents?
enjoy hobbies?
lost or disorientated?
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10
Q

assessment of orientation of patient?

A

name
address
where are we
day, date, month, year, time

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11
Q

assessment of attention of patient?

A

can you read or watch tv

assess attention formally

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12
Q

assessment of memory of patient?

A
why are you here?
how long have you been here?
do you forget conversations?
do you forget names?
do you repeat yourself?
name of doctor?
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13
Q

assessment of mood of patient?

A

do you feel anxious or worried

how has your mood been

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14
Q

what is the 4AT test

A

assessment for delirium

moderate to severe cognitive impairment

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15
Q

components of the 4AT

A

alertless - normal, sleepy, abnormal
AMT-4 - age, DOB, place, year
attention by months backwards
acute/fluctuating

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16
Q

bedside cognitive tests?

A

GPCOG
6CIT
clock drawing

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17
Q

MMSE scoring and advantages

A

at least 24/30
quick
blank pen and paper
memorised by clinician

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18
Q

MMSE disadvantages

A

not age adjusted
poor for exec function
poor in severe impairment
may not address early issues

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19
Q

ACE-III scoring?

A

100 with 5 domains

cut off 88/82

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20
Q

uses for neuropsychological assessment

A

areas of deficit and preserved functioning in cog profile
info regarding prognosis
baseline functioning assessment
inform and facilitate intervention and strategies
monitor cognitive function
indicator of recovery
effectiveness of intervention

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21
Q

what is dementia

A

progressive and irreversible global cognitive decline with associated loss of functioning

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22
Q

diagnostic testing for dementia?

A
hx of global decline of months to years 
cognitive test corroborating hx 
no reversible cause 
collateral hx 
OT assessment
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23
Q

what test is the standard cognitive test in diagnosis of dementia

A

ACE-III

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24
Q

what test can be used in patients unable to do the addenbrookes

A

MoCA

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25
Q

when would detailed neuropsychological testing be indicated in a patient

A

those expected to do well in addenbrookes or younger patients with no radiological features on CT/MRI/SPECT

26
Q

what is often assessed at OT assesment of dementia

A
activities 
washing 
dressing 
using phone 
shopping 
basic cooking
27
Q

possible reversible causes of cognitive impairment?

A
delirium
alcohol
substance misuse 
neurological infection or inflammation 
brain lesions and SOLs 
depression 
medications 
thyroid or other metabolic/endocrine
28
Q

what is mild cognitive impairment

A

cognitive impairment with little deteriration of function
MoCA 24-26 and ACE-III 75-90
repeat annually

29
Q

what is subjective cognitive impairment

A

patients feels they have an impairment but testing and day to day function and normal
association to anxiety/depression or friend/relative with dementia
increased anxiety about memory causes more lapses

30
Q

what is the general outpatient pathway for someone with dementia

A

referral to any >55 with suspected dementia
nurse led memory clinic for MSE and cognitive tesing
consultant review and imaging
follow up
diagnosis
CMHT and post diagnostic support

31
Q

clinical features of AD?

A

memory loss - short term
dysphasia
dyspraxia
agnosia

32
Q

CT/MRI features of AD

A

normal
medial temporal atrophy
temporoparietal atrophy

33
Q

variants of AD

A

frontal

posterior cortical atrophy

34
Q

clinical features of vasc dementia ?

A
dysphasia 
dyscalculia 
frontal lobe and affective symptoms 
focal neuro signs 
vascular risk factors 
stepwise decline
35
Q

CT/MRI and SPECT features of vascular dementia

A

CT/MRI - medium to severe vascular disease or multiple lacunar infarcts
SPECT - patchy reduction in tracer uptake through brain

36
Q

clinical features of behavioural FTD?

A
behavioural change 
executive dysfunction 
impulsive 
lost social skills 
apathy 
diet change 
obsessive
37
Q

clinical features of primary progressive aphasia FTD?

A

effortful non fluent speech
lack of grammar
lack of words
articulatory error

38
Q

clinical features of semantic FTD?

A

impaired understanding of word meaning, fluent but empty speech, difficulty with names

39
Q

CT/MRI and SPEDCT features of FTD

A

CT/MRI have frontotemporal atrophy

reduced frontotemporal tracer uptake

40
Q

clinical features of DLB?

A
two of the following 
visual hallucination 
flux in cognition 
REM sleep disorder 
parkinsonism but not >1y to dementia onset 
\+ve dat scan
41
Q

features of dementia with parkinsons disease

A

parkinsonism >1yrs to dementia onset
similar to lewy body but different pathology
+ve DAT scan

42
Q

when to suspect a less common cause dementia

A
fast progression 
younger patient
neurological signs 
FHx of a rare cause 
clues in med Hx - HIV
something just isnt fitting right
43
Q

who to scan and with what with dementia

A

CT standard but not really advised if >80 and typical hx AD
MRI if young, fast progressing or atypical
SPECT for FTD or certain types AD
DAT scan for DPD/DLB when there arent enough supporting features

44
Q

cholinesterase inhibitors used in AD

A

donezepil
rivastigmine
galanramine

45
Q

cholinesterase inhibitors used in DLB and DPD

A

rivastigmine

donezepil

46
Q

how do cholinesterase inhibitors act to treat dementia and what types are they more effective in

A

slow cognitive decline

DLB/DPD over AD

47
Q

side effects of anticholinesterase inhibitors

A
nausea 
diarrhoea 
muscle cramp
bradycardia 
worsening COPD/asthma
48
Q

what should you check before prescribing cholinesterase inhibitors and what is a contraindication

A

check pulse before prescription and dose increases

not for active PUD or severe asthma/COPD

49
Q

what is memantine, what dementia is it used for and what does it do

A

AD

slow cognitive declin and prevent BPSD

50
Q

what can memantine cause and what are possible side effects

A

HTN

sedation, dizziness, headache, constipation

51
Q

describe conditions surrounding dementia and driving

A

discuss at diagnosis
report to DVLA and allow pt to fill out form
doctor decides if pt can drive whilst DVLA investigates

52
Q

in middle and later stage dementia what aspects become more prevalent

A

behavioural and psychiatric

greater need for support and possible institutionalised care

53
Q

behavioural/psychological symptoms associated with dementia

A
hallucination 
delusion 
insomnia 
anxiety
disinhibition 
agitation 
agression 
depression
54
Q

initial management of dementia within paitnets

A
chart behaviours 
review physical symptoms, examine, investigate 
side effects of drugs?
comfort patient 
environment 
activity and exercise 
sleep hygiene 
carer education
55
Q

pharmacological management of FTD for agitation

A

trazodone

56
Q

pharmacological mx of agitation for AD

A

antipsychotics

citalopram, memantine, analgesia, dextromorphan

57
Q

drugs for depression in dementia

A

antidepressant and adjunct

58
Q

drugs for anxiety in dementia

A

antidepressant, BZD, pregabalin

59
Q

drugs for visual hallucination in dementia

A

cholinesterase inhibitors/antipsychotics

60
Q

drugs for insomnia in dementia

A

melatonin
z drugs
BZD
sedating antidepressants

61
Q

drugs for agitation/aggression in dementia

A
BZD
antipsychotic 
sedating antidepressants 
cholinesterase inhibitors 
memantine 
pregabalin