Mood disorder- Bipolar disorder Flashcards
What is a Bipolar disorder?
affective disorder; Characterized by dramatic changes or extreme of mood (includes depressive disorder & Bipolar disorder)
Swing between mania and depression
What are the 3 classes of Bipolar disorder?
Bipolar I disorder
Bipolar II disorder
Cyclothymic disorder
Describe Bipolar I disorder.
Severe shift in mood, energy between Major depressive and Manic episodes
Have experienced at least one manic episode
Initially euphoric, energized, don’t sleep or aet, take risks, poor insight
May proceed to psychosis, irritation, agitation, exhaustion and depression
What are the diagnostic criteria for Bipolar I disorder, DSM-5?
Manic episode
1. Abnormally persistent elevated mood (irritability), goal-directed activity or energy lasting a minimum of 1 week, persistent most of the day
2. Must exhibit at least 3 symptoms (4 if only irritable)
Grandiose, Decrease need sleep, Talkative, Flight of ideas, Distractibility, Increase goal directed activity or psychomotor agitation, Activities with painful consequences
3. Severe impairment in social or work function or need for hospitalization for safety or psychotic features
4. Not caused by substances or medical condition
Describe Bipolar II disorder.
Experience at least one hypomanic episode with a major depressive episode
Hypomania is a lower level, less dramatic mania
Still causes significant issues in functioning
Describe a hypomania episode in a Bipolar II patient.
Excessive energy & activity for at least 4 days
Involves at least 3 behaviours:
Grandiosity, Decrease need for sleep, Talkative, Flight of ideas, Distractibility, Increase goal directed activity or psychomotor agitation, Activities with painful consequences
Psychosis is never present*
Describe Cyclothymic disorder.
Alternates between hypomania and mild/moderate depression
over 2 years adult: irritable, hypomania
over 1 year kids: irritable, sleep disturbance
Rapid cycling: >4 mood changes over 12 months, or 1 mos, or 1 day: More difficult to treat
What are other Bipolar disorders?
Substance/Medication - Induced Bipolar & Related Disorder
Bipolar & Related Disorder due to another medical condition
Other Specific Bipolar and Related Disorder
Unspecific Bipolar and Related Disorder
What is the epidemiology of Bipolar disorder?
Lifetime risk is 4%
Age of onset of Bipolar I is 18 years, and Bipolar II is 20 years
Men increase legal probs, violence
Women increase abuse alcohol, suicide, thyroid: Severe post partum < 2 wks = 4x higher
d/t hormone, sleep deprive?
What is the epidemiology of Cyclothymia disorder?
Usually begins in adolescence or early adulthood
15 - 50% risk BP I or II
Genetic risk if family has BP
What are the comorbidity for Bipolar I?
75% have anxiety disorder
1/2 have a substance use disorder
Difficult to differentiate from other disorder (ADHD, impulse, conduct disorder)
Higher than normal rate or serious medical condition (migraines,metabolic syndrome)
What are the comorbidity for Bipolar II?
75% have anxiety disorder (d/t depressive side)
37% have substance use disorder (hypomanic symptoms)
Eating disorder 14%
What are the comorbidity with Cyclothymic disorder?
Substance use disorder rt self med
Sleep disorder
ADHD (children) more common
What is the etiology for environmental and psychological factors?
Environmental:
Worldwide, all ethnic groups
Slightly more: high SES, educated
Children low SES, stress and adversity
Psychological:
psychological theories are largely dismissed
What are the etiology for Biological factors?
Genetics: Twins 70%, Genetica markers, 15- 30 % if one parent, High IQ’s, Verbal in childhood, Artist/writer/ highly educated
Neurobiological: Role of neurotransmitters, Most likely interactions among various chemicals
Brain structure/function: Imaging=changes, Dysfunction prefrontal cortical region, Dysfunction hippocampus & amygdala
Neuroendocrine: HPA (axis), Hypothyroidism increase, Increase peripheral inflammation, Role of estrogen