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PHARM 233 (Final) - Drugs > Monoclonal Antibodies & Kinase Inhibitors > Flashcards

Monoclonal Antibodies & Kinase Inhibitors Flashcards

1
Q

Etoposide

A

Plant Based Compounds

Characteristics
- Mandrake Root
- Targets DNA

MOA:
- Topoisomerase II inhibitor

AE:
- Alopecia
- Cardiotoxicity
- Nausea
- Vomiting
- Bone Marrow Suppression

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2
Q

Prednisolone

A

Hormone

Characteristics:
- Targets Leukemia, Lymphoma

MOA:
- Inhibit Lymphocyte Proliferation

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3
Q

Flutamide

A

Hormones

Characteristics:
- Treats Prostate Cancer

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4
Q

Cyproterone

A

Hormones

Characteristics:
- Treats Prostate Cancer

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5
Q

Bicalutamide

A

Hormones

Characteristics:
- Treats Prostate Cancer

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6
Q

Anastrozole

A

Suppress synthesis of oestrogen from androgens in adrenal cortex

Treat Breast Cancer in Postmenopausal Women

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7
Q

Letrozole

A

Suppress synthesis of oestrogen from androgens in adrenal cortex

Treat Breast Cancer in Postmenopausal Women

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8
Q

Exemestane

A

Suppress synthesis of oestrogen from androgens in adrenal cortex

Treat Breast Cancer in Postmenopausal Women

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9
Q

Vincristine

A

Antimicrotubules (Vinca Alkaloids)
- Breast, Lymphoma

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10
Q

Vinblastine

A

Antimicrotubules (Vinca Alkaloids)
- Lymphoma

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11
Q

Vinorelbine

A

Antimicrotubules (Vinca Alkaloids)
- Breast, Lung

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12
Q

Paclitaxel

A

Antimicrotubules (Vinca Alkaloids)
- Targets Breast, Lung

AE:
- Bone Marrow Suppression and Neurotoxicity

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13
Q

Docetaxel

A

Antimicrotubules (Vinca Alkaloids)
- Targets Breast, Prostate

AE:
- Bone Marrow Suppression and Neurotoxicity

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14
Q

Nab-Paclitaxel

A

Antimicrotubules (Vinca Alkaloids)
- Targets Breast

AE:
- Bone Marrow Suppression and Neurotoxicity

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15
Q

Rituximab

A

Monoclonal Antibodies

Binds CD20 on B-Cells
- Treats Hodgkin’s Lymphoma

AE:
- Hypotension
- Chills and Fevers

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16
Q

Trastuzumab

A

Monoclonal Antibodies

Inhibits oncogenic receptor HER2
- Targets Breast Cancer

AE:
- Hypotension
- Chills and Fevers
- Cardiotoxicity

17
Q

Bevacizumab

A

Monoclonal Antibodies

Targets VEGF
- Treats Colorectal Cancer

AE:
- Hypotension
- Chills and Fevers

18
Q

Catumaxomab

A

Monoclonal Antibodies

Targets EpCAM
- Clears Cancer Cells

AE:
- Hypotension
- Chills and Fevers

19
Q

Imatinib

A

Targets BCR-ABL Protein
- Treats Leukemia

AE:
- GI Symptoms (Pain, Diarrhea, Nausea)
- Fatigue
- Headaches
- Cardiotoxicity

20
Q

Erlotinib

A

EGFR Inhibitor
- Targets Lungs

AE:
- GI Symptoms (Pain, Diarrhea, Nausea)
- Fatigue
- Headaches
- Cardiotoxicity

21
Q

Sorafenib

A

Pan Kinase Inhibitor
- Targets lots of kinases

AE:
- GI Symptoms (Pain, Diarrhea, Nausea)
- Fatigue
- Headaches
- Cardiotoxicity

22
Q

Gefitnib

A

EGFR Inhibitor
- Targets Lungs

AE:
- GI Symptoms (Pain, Diarrhea, Nausea)
- Fatigue
- Headaches
- Cardiotoxicity

23
Q

Afatinib

A

EGFR Inhibitor
- Targets Lungs

AE:
- GI Symptoms (Pain, Diarrhea, Nausea)
- Fatigue
- Headaches
- Cardiotoxicity

24
Q

Osimertinib

A

EGFR Inhibitor
- Targets Lungs

AE:
- GI Symptoms (Pain, Diarrhea, Nausea)
- Fatigue
- Headaches
- Cardiotoxicity

25
Q

Cetuximab

A

EGFR Inhibitor
- Targets Colon

AE:
- GI Symptoms (Pain, Diarrhea, Nausea)
- Fatigue
- Headaches
- Cardiotoxicity

26
Q

Panitumumab

A

EGFR Inhibitor
- Targets Colon

AE:
- GI Symptoms (Pain, Diarrhea, Nausea)
- Fatigue
- Headaches
- Cardiotoxicity

27
Q

Hydroxyurea

A

Other Chemotherapeutics
- Targets Leukemia

28
Q

Bleomycin

A

Other Chemotherapeutics
- Targets Lymphoma

29
Q

Asparaginase

A

Other Chemotherapeutics
- Targets Leukemia

30
Q

Tamoxifen

A

Other Chemotherapeutics
- Targets Breast

PHARM 233 (Final) - Drugs (15 decks)

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