Monoclonal Antibodies & Kinase Inhibitors

Question 1

Etoposide

Answer 1

Plant Based Compounds

Characteristics
- Mandrake Root
- Targets DNA

MOA:
- Topoisomerase II inhibitor

AE:
- Alopecia
- Cardiotoxicity
- Nausea
- Vomiting
- Bone Marrow Suppression

Question 2

Prednisolone

Answer 2

Hormone

Characteristics:
- Targets Leukemia, Lymphoma

MOA:
- Inhibit Lymphocyte Proliferation

Question 3

Flutamide

Answer 3

Hormones

Characteristics:
- Treats Prostate Cancer

Question 4

Cyproterone

Answer 4

Hormones

Characteristics:
- Treats Prostate Cancer

Question 5

Bicalutamide

Answer 5

Hormones

Characteristics:
- Treats Prostate Cancer

Question 6

Anastrozole

Answer 6

Suppress synthesis of oestrogen from androgens in adrenal cortex

Treat Breast Cancer in Postmenopausal Women

Question 7

Letrozole

Answer 7

Suppress synthesis of oestrogen from androgens in adrenal cortex

Treat Breast Cancer in Postmenopausal Women

Question 8

Exemestane

Answer 8

Suppress synthesis of oestrogen from androgens in adrenal cortex

Treat Breast Cancer in Postmenopausal Women

Question 9

Vincristine

Answer 9

Antimicrotubules (Vinca Alkaloids)
- Breast, Lymphoma

Question 10

Vinblastine

Answer 10

Antimicrotubules (Vinca Alkaloids)
- Lymphoma

Question 11

Vinorelbine

Answer 11

Antimicrotubules (Vinca Alkaloids)
- Breast, Lung

Question 12

Paclitaxel

Answer 12

Antimicrotubules (Vinca Alkaloids)
- Targets Breast, Lung

AE:
- Bone Marrow Suppression and Neurotoxicity

Question 13

Docetaxel

Answer 13

Antimicrotubules (Vinca Alkaloids)
- Targets Breast, Prostate

AE:
- Bone Marrow Suppression and Neurotoxicity

Question 14

Nab-Paclitaxel

Answer 14

Antimicrotubules (Vinca Alkaloids)
- Targets Breast

AE:
- Bone Marrow Suppression and Neurotoxicity

Question 15

Rituximab

Answer 15

Monoclonal Antibodies

Binds CD20 on B-Cells
- Treats Hodgkin’s Lymphoma

AE:
- Hypotension
- Chills and Fevers

Question 16

Trastuzumab

Answer 16

Monoclonal Antibodies

Inhibits oncogenic receptor HER2
- Targets Breast Cancer

AE:
- Hypotension
- Chills and Fevers
- Cardiotoxicity

Question 17

Bevacizumab

Answer 17

Monoclonal Antibodies

Targets VEGF
- Treats Colorectal Cancer

AE:
- Hypotension
- Chills and Fevers

Question 18

Catumaxomab

Answer 18

Monoclonal Antibodies

Targets EpCAM
- Clears Cancer Cells

AE:
- Hypotension
- Chills and Fevers

Question 19

Imatinib

Answer 19

Targets BCR-ABL Protein
- Treats Leukemia

AE:
- GI Symptoms (Pain, Diarrhea, Nausea)
- Fatigue
- Headaches
- Cardiotoxicity

Question 20

Erlotinib

Answer 20

EGFR Inhibitor
- Targets Lungs

AE:
- GI Symptoms (Pain, Diarrhea, Nausea)
- Fatigue
- Headaches
- Cardiotoxicity

Question 21

Sorafenib

Answer 21

Pan Kinase Inhibitor
- Targets lots of kinases

AE:
- GI Symptoms (Pain, Diarrhea, Nausea)
- Fatigue
- Headaches
- Cardiotoxicity

Question 22

Gefitnib

Answer 22

EGFR Inhibitor
- Targets Lungs

AE:
- GI Symptoms (Pain, Diarrhea, Nausea)
- Fatigue
- Headaches
- Cardiotoxicity

Question 23

Afatinib

Answer 23

EGFR Inhibitor
- Targets Lungs

AE:
- GI Symptoms (Pain, Diarrhea, Nausea)
- Fatigue
- Headaches
- Cardiotoxicity

Question 24

Osimertinib

Answer 24

EGFR Inhibitor
- Targets Lungs

AE:
- GI Symptoms (Pain, Diarrhea, Nausea)
- Fatigue
- Headaches
- Cardiotoxicity

Question 25

Cetuximab

Answer 25

EGFR Inhibitor - Targets Colon AE: - GI Symptoms (Pain, Diarrhea, Nausea) - Fatigue - Headaches - Cardiotoxicity

Question 26

Panitumumab

Answer 26

EGFR Inhibitor - Targets Colon AE: - GI Symptoms (Pain, Diarrhea, Nausea) - Fatigue - Headaches - Cardiotoxicity

Question 27

Hydroxyurea

Answer 27

Other Chemotherapeutics - Targets Leukemia

Question 28

Bleomycin

Answer 28

Other Chemotherapeutics - Targets Lymphoma

Question 29

Asparaginase

Answer 29

Other Chemotherapeutics - Targets Leukemia

Question 30

Tamoxifen

Answer 30

Other Chemotherapeutics - Targets Breast