Cytotoxic Drugs Flashcards
Cyclophosphamide
Alkylating Agent (Nitrogen Mustard)
Characteristics:
- Targets Breast, Lymphoma
MOA:
- Forms covalent bonds with DNA and prevents DNA replication
AE:
- Teratogenicity
- Loss of Hair
- Bone Marrow Toxicity
Probarbazine
Alkylating Agent (Triazine/Tetrazine)
Characteristics:
- Targets Lymphoma
MOA:
- Forms covalent bonds with DNA and prevents DNA replication
AE:
- Teratogenicity
- Loss of Hair
- Bone Marrow Toxicity
Cisplatin
Alkylating Agent (Platinum)
- Forms covalent bonds with DNA and prevents DNA replication
Targets Lungs
Carboplatin
Alkylating Agent (Platinum)
- Forms covalent bonds with DNA and prevents DNA replication
Targets Lungs
Oxalipatin
Alkylating Agent (Platinum)
- Forms covalent bonds with DNA and prevents DNA replication
Targets Colon
Methotrexate
Antimetabolite
(Folate Antagonist)
- Prevents synthesis of nucleotides and material needed for DNA synthesis
Targets Leukemia
AE:
- Bone marrow toxicity
- Damage to GI tract epithelium
Pemetrexed
Antimetabolite
(Folate Antagonist)
- Prevents synthesis of nucleotides and material needed for DNA synthesis
Targets Lungs
AE:
- Bone marrow toxicity
- Damage to GI tract epithelium
Fluorouracil
Antimetabolite
(Pyrimidine Analogue)
- Block/Subvert one or more of the metabolic pathways involved in DNA synthesis
Targets Colon, Breast
AE:
- Bone marrow toxicity
- Damage to GI tract epithelium
Cytarabine
Antimetabolite
(Pyrimidine Analogue)
- Block/Subvert one or more of the metabolic pathways involved in DNA synthesis
Targets Leukemia
AE:
- Bone marrow toxicity
- Damage to GI tract epithelium
Capecitabine
Antimetabolite
(Pyrimidine Analogue)
- Block/Subvert one or more of the metabolic pathways involved in DNA synthesis
Targets Colon, Breast
AE:
- Bone marrow toxicity
- Damage to GI tract epithelium
Gemcitabine
Antimetabolite
(Pyrimidine Analogue)
- Block/Subvert one or more of the metabolic pathways involved in DNA synthesis
Targets Lungs
AE:
- Bone marrow toxicity
- Damage to GI tract epithelium
Mercaptopurine
Antimetabolite
(Purine Analogue)
- Block/Subvert one or more of the metabolic pathways involved in DNA synthesis
Targets Leukemia
AE:
- Bone marrow toxicity
- Damage to GI tract epithelium
Doxorubicin
Topoisomerase Inhibitors -Antibiotic
(Anthracyclines)
MOA:
- Substances of microbial origin that prevent mammalian cell division
Targets Breast, Lymphoma
AE:
- Cardiotoxicity
- Alopecia
Idarubicin
Topoisomerase Inhibitors -Antibiotic
(Anthracyclines)
MOA:
- Substances of microbial origin that prevent mammalian cell division
Targets Leukemia
AE:
- Cardiotoxicity
- Alopecia
Epirubicin
Topoisomerase Inhibitors -Antibiotic
(Anthracyclines)
MOA:
- Substances of microbial origin that prevent mammalian cell division
Targets Breast
AE:
- Cardiotoxicity
- Alopecia
