Anti-Influenza

Question 1

Amantadine

Answer 1

Characteristics
- Target Type A

MOA:
- Inhibit M2 Protein Channel Function
–> Open Channel = Close it
–> Closed Channel = Stabilize it

M2 enables hydrogen to enter, lowering pH inside virus, needed for uncoating

Question 2

Rimantadine

Answer 2

Characteristics
- Target Type A

MOA:
- Inhibit M2 Protein Channel Function
–> Open Channel = Close it
–> Closed Channel = Stabilize it

M2 enables hydrogen to enter, lowering pH inside virus, needed for uncoating

Resistance:
- M2 Protein Channel can mutate

Question 3

Oseltamivir

Answer 3

Characteristics:
- Target A and B
- Target Amantadine Resistant Virus

MOA:
- Inhibits Viral Neuraminidase
–> Preventing it from cleaving and releasing new viruses from cell

Resistance:
- Neuraminidase Enzyme mutates
- More resistance in children
- Resistant strains are less virulent

Question 4

Zanamivir

Answer 4

Characteristics:
- Target A and B
- Target Oseltamvir Resistant Virus

MOA:
- N-acetylneuraminic acid analogue
–> Inhibits Viral Neuraminidase
–> Preventing it from cleaving and releasing new viruses from cell

Resistance:
- Neuraminidase Enzyme mutates
- More resistance in children
- Resistant strains are less virulent

Question 5

Peramivir

Answer 5

MOA:
- Neuraminidase Inhibitor
–> Preventing it from cleaving and releasing new viruses from cell

Question 6

Xofluza

Answer 6

Characteristics:
- New compound

MOA:
- Inhibits endonuclease function of viral PA Polymerase
–> Inhibits mRNA replication

Question 7

Remdesivir

Answer 7

Characteristics:
- Treats MERS (Coronavirus)

MOA:
- Remdesivir-PPP inhibits RNA dependent RNA polymerase of MERS

Question 8

Molnupiravir

Answer 8

MOA:
- Incorporates Molnupiravir Triphosphate (MTP) into RNA sequence
–> Coding errors (C –> U Mutation)

Question 9

Paxlovid

Answer 9

Nirmatrelvir: Protease Inhibitor
- Prevents Virus from maturing

Ritonavir: Protease Enhancer
- Inhibits Cytochrome 3A4 allowing for higher peak concentration