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Pharmaco > Monoclonal Antibodies > Flashcards

Monoclonal Antibodies Flashcards

1
Q

Tox

A

•Bezlotoxumab: Clostridium difficile infections (Pseudomembranous colitis)

•Obiltoxaximab: Bacillus anthracis (Anthrax)

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2
Q

NE/N

A

•Erenumab
•Eptinezumab
•Galcanezumab
•Fremanezumab

-agianst CGRP
-for Prophylaxis of Migraine

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3
Q

BAC

A

Raxibacumab - anthrax

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4
Q

VI

A

Palivizumab- RSV

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5
Q

CI/C

A

•Abciximab. - # GP IIb/llIa
-Antiplatelet drug
•Bevacizumab - #VEGE
-usefull against many Ca
•Caplacizumab - #vWE
-useful against TTP
•Emicizumab -Binding of fa IX & X;
-useful in hemophilia.
• Ramucirumab -#VEGF
-useful in NSCLC & GEJ
tumors
• Brolucizumab -#VEGF
-useful in ARMD
•Idarucizumab -Tx of Dabigatran
toxicity
•Alirocumab -#PCSK-9; useful in HHC
•Evolocumab -#PCSK-9 ; useful in HHC
(Homozygous Hyper-Cholesterolemia)

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6
Q

OS

A

•Denosumab -#RANK-ligand
-Useful in Osteoporosis
•Romosozumab - #Sclerostin,
- dual action
(#Osteoclast & ✓ Osteoblast)
•Burosumab -#FGF-23
-promotes PO¾ reabsorption
in both kidneys intestines
-Useful in X-linked hypophosphatemia

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7
Q

KI/K

A

•Ixekizumab: against IL-17
•Secukinumab: against IL-17
•Ustekinumab: against IL-12,23
•Risankizumab: against IL-23
•Guselkumab: against IL-23.
•Tildrakizumab: against IL-23

-#Interlukins
- useful; Plaques and Psoriasis

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8
Q

ANIBI

A

•Ranibizumab -#Angiogenesis
-#VEGF, Useful in ARMD

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9
Q

TNF-inhibitors (L/LI)

A

A -Adalimumab
C -Certolizumab
E -Etanercept
Inhibitors -Infliximab
Goli -Golimumab

-RA, Psoriasis, Crohn’s Dis

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10
Q

CD -25# (LI/L)

A

Daclizumab
Basiliximab
-Useful in transplantations

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11
Q

B-LyS# (B-lymphocyte stimulator) #BAFF (LI/L)

A

•Belimumab
Useful in SLE

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12
Q

C5# (LI/L)

A

•Eculizumab
•Ravulizumab
-Useful in Paroxysmal Nocturnal
Hemoglobinuria (PNH)

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13
Q

LFA-1# (LI/L)

A

•Efalizumab
Useful in Psoriasis

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14
Q

LFA-3# (LI/L)

A

Alefacept
-psoriasis

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15
Q

CCR-4# (Chemokine receptor-4) (LI/L)

A

•Mogamulizumab
-Useful in;
Mycosis Fungoides & Sezary syndrome

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16
Q

Alpha-4 integrin# (LI/L)

A

•Natalizumab
Useful in MS, CD

17
Q

Alpha-4/Beta-7integrin# (LI/L)

A

-for Asthma
#IL5
•Omalizumab
•Reslizumab

18
Q

CD-20# (LI/L)

A

•Ocrelizumab
-usefull in MS

19
Q

IL-6R # (LI/L)

A

•Sarilumab: Useful in RA

•Tocilizumab: Useful in RA: treatment of
cytokine release syndrome

•Sactralizumab: Useful for treatment of
Veno-occlusive disease in sickle cell anemia

20
Q

P-Selectin #(LI/L)

A

•Crizanlizumab: Useful for treatment of Venoocclusive dis in sickle cell anemia

21
Q

Cd-4 # (LI/L)

A

•lbalizumab: Useful in HIV

22
Q

IL-17RA # (LI/L)

A

•Brodalumab: Useful in Psoriasis

23
Q

IL-4R Alpha # (LI/L)

A

•Dupliumab: Useful in atopic dermatitis

24
Q

IFN- Gamma # (LI/L)

A

•Emapalumab: Useful in Primary hemophagocytic lymphohistiocytosis

25
Q

Kallikrein # (LI/L)

A

Kallikrein -(HMWK) to bradykinin

•Lanadelumab:
-Useful in;
Hereditary Angioneurotíc
Edema (HAE)

26
Q

Immune Check point Inhibitors (LI/L)

A

•PD-1 #
Nivolumab. : HL, NSCLC,MM
Pembrolizumab :MM, NSCLC,Head and
Neck cancers
Cemiplimab. :Squamous cell
carcinoma of skin

• PD-L1 #
Atezoli zumab :Urothelial & Breast
cancers
Avelumab. :Merkel cell carcinoma
Duruvalumab :Bladder carcinoma

•CTLA-4 #
Ipilimumab: Malignant Melannoma

27
Q

TU/TA Growth factor receptors

A

•EGFR (HER-1)
Cetuximab: Colorectal, Head &Neck Ca
Trastuzumab: Colorectal Ca, Breast Ca Necitumumab: NSCLC
Nimotuzumab: Head & Neck Ca, Glioma

•HER-2
Trastuzumab: Useful in breast cancers Pertuzumab : “ “
-cardiotoxīc S/E

•PDGFR-Alpha
Olaratumab. soft tissue sarcoma

28
Q

TU/TA CD Markers

A

CD-3,19 -Blinatumomab -Ph-ALL
CD-19 -TAFASTIAMAB -DLBCL
CD-20 -RITUXIMAB. -NHL, CLL
CD-20 -IBRITUMOMAB -BCL, CLL
CD-20 -OFATUMUMAB -CLL
CD-20 -TOSITUMOMAB -BCL
CD-20 -OBINTUZUMAB -BCL, CLL
CD-22 -INOTUZUMAB -ALL
CD-30 -BLINATUMOMAB -HL, TCL
CD-33 -GEMTUZUMAB -AML
CD-38 -DARATUMUMAB -MM
CD-38 -SATUXIMAB -MM
CD-52. -ALEMTUZUMAB -CLL
CD-79B -POLATUZUMAB -DLBCL
CD-319 -ELOTUZUMAB -MM
(SLAM-F7)

29
Q

TU/TA IL-6

A

Siltuximab: RCC, Castleman’s disease

30
Q

TU/TA TROP-2

A

Sacituzumab: Breast cancers

31
Q

TU/TA IGF-1R

A

Teprotumumab: Thyroid eye disease

32
Q

TU/TA Nectin -4

A

Enfortumab: Urothelial cancer

33
Q

TU/TA Glycolipid GD-2

A

Dinutuximab; Neuroblastoma

34
Q

TU/TA
BCMA (B-Cell Maturation Antigen)

A

Belantamab: Multiple Myeloma

Pharmaco (8 decks)

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