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Microbiology Final > Mono & Lyme > Flashcards

Mono & Lyme Flashcards

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Biology 101 flashcards
1
Q

Cause of Mono

A

EBV

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2
Q

Cancer linked to EBV

A

Burkitt’s lymphoma

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3
Q

Mono incubation period

A

1-2 months

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4
Q

What type of infection is mono?

A

B-cell infection w/ T-cell reaction

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5
Q

Mono prodrome

A

3-5 days of HA, fever, malaise, fatigue

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6
Q

Mono presentation

A

Sore throat
Symmetrical LAD
Fever
Hepatomegaly (sometimes)

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7
Q

Downey cells

A

Atypical lymphocytes found in circulation during mono infection (T-cells)

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8
Q

Transmission of EBV

A

Person-to-person

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9
Q

Peak incidence of mono

A

17-25

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10
Q

EBV Diagnosis

A

Heterophile antibodies***
Agglutination of horse RBCs
IgM anti-VCA (confirmatory)

Pre-teen pts may not have strong heterophile antibody response due to immature immune system (use anti-VCA)

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11
Q

Penicillin rash

A

Treating mono w/ abx

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12
Q

CMV

A

Similar to EBV, but does NOT produce heterophile antibodies

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13
Q

CMV is problematic for…

A

Transplant pts
Immune suppressed
Pregnant pts

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14
Q

Reservoir for CMV

A

Children with “minor colds”

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15
Q

Outbreaks of mumps

A

“Breakthrough” cases

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16
Q

Juvenile arthritis

A

Lyme disease

17
Q

Stages of Lyme disease

A
  1. Acute localized (70-80%)
  2. Subacute disseminated (70%-untreated)
  3. Chronic Disease
18
Q

Acute localized disease

A
  • Bulls eye rash at bite site, fades in a month

- Flu-like symptoms.

19
Q

Subacute disseminated disease

A
  • Weeks to months after infection.
  • Flu-like symptoms
  • Asymmetric arthritis (brief duration) of large joints (60%)
  • New annular skin lesions (50%)
  • Hepatitis (20%)
  • Meningitis (15%)
  • Conjunctivitis (10%)
20
Q

Chronic lyme disease

A

MSK manifestations primarily:

  • More persistent arthritis attacks
  • 2 to 3 yrs after infection
21
Q

Cause of lyme

A

Borreliella burgdorferi (N. America & Europe)***
B. garinii - Eurasia
B. afzelii - Eurasia

22
Q

Lyme disease vector

A

Ticks (Ixodes sp)

  • Deer OR
  • Black-legged
23
Q

Lyme reservoir

A

Small mammals and birds:

  • Rodents
  • Rats
  • Mice***
24
Q

Lyme diagnosis

A

Clinical findings in endemic area

Serology:

  • EIA plus western blot if EIA positive
  • False positives with syphilis, mono, SLE, RA, oral infections with spirochetes
  • Pts positive by 4th WEEK of infection
25
Q

Lyme prevention

A

Repellents with DEET
Remove tick promptly (w/in 24 hours)
Control tick sources (ie. mice)

Vaccine WAS available

26
Q

Post Treatment Lyme Disease Syndrome

A

10-20% treated have lingering symptoms of fatigue, pain, and joint problems
May reflect residual tissue damage and auto-immune responses
Most improve with time

27
Q

Other tick bite consequences

A

Red meat allergy

Microbiology Final (8 decks)

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