Monday - muscle cancer and stuff

Question 1

signs of DMD?

Answer 1

Gower’s maneuver (placing hands on knees to help standing)
pseudohypertrophy of calf muscles (fat in place of muscle)
increased creatine kinase.

Question 2

Myotonic dystrophy

What does muscle biopsy shows

Answer 2

Autosomal dominant
Defect in chloride channel, results in myotonia (sustained involuntary contraction)

atrophy of type 1 fiber and ring fibers.
elevated creatine kinase

Question 3

Spinal muscular atrophy

Answer 3

autosomal recessive, wordning hoffman

compensatory fibers.

chromosome 5 SMN1 gene

early onset

Question 4

Mallignant hyperthermia

Answer 4

Mutations in ion channels can lead to hyperthermia upon exposure to anesthetic.

Question 5

3 subgroups of inflammatory myopathies

Answer 5

infectious
non infectious inflamatory*** there are three
associated with systemic inflamatory disease

Question 6

Dermatomyositis

Answer 6

heliotrope rash (purple eyelids)

Gottron papules - scaling erythematous eruption over the knuckles.

15-25% of patients have and underlying malignancy

Question 7

Polymyositis

Answer 7

similar to dermatomyositis, but no skin involvement.

Question 8

Inclusion body myositis

Answer 8

most common inflammatory myopathy >65
distal, asymmetric muscle wasting
vacuole within a myocyte

Question 9

Lambert-eaton treatment

Answer 9

diaminopyridine

Question 10

Creatine kinase converts

Muscles have ____ isoform when damages

Answer 10

creatine to phosphocreatine

CK-MB when damaged, CK-MM when not

Question 11

Rhabdomyolysis. what can it cause

Answer 11

elevated levels of myoglobin.

tubular necrosis with acute renal failure (myoglobinuria)